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Heteropian twins or "by-products" of evolution
Time of Update: 2021-01-06
If the model includes double ovulation rates that increase with age and fetal survival rates that decrease with age, then the twin rates of women of all ages can be best explained.
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The better the mentality, the stronger the memory
Time of Update: 2021-01-06
Photo Source: BillionPhotos.com People always want some memories to last a lifetime, but many physical and emotional factors negatively affect their ability to remember information A new study published recently in the journal Psychological Science found that those who feel warm and happy - what psychologists call "positive effects" - are less likely to experience memory loss as they age.
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"Phase separation" phenomenon makes anticancer drugs more effective
Time of Update: 2021-01-06
pharmaceutical industry has long assumed that drug molecules are evenly distributed when they enter cells, but biologist Rick Young says "this is a far from the truth." In a recent study published in Science, Young and colleagues at the Whitehead Institute in Cambridge, Massachusetts, found that cancer drug compounds are concentrated precisely in cells because of a phenomenon called phase separation, through which all cells separate their components.
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Liang Wei's task force reported a large-scale tumor drug protein perturbation effect screening data set
Time of Update: 2021-01-06
However, existing large-scale gene or compound screening data sets lack response indicators centered on protein expression levels, mainly because large-scale quantification of proteins is still difficult, so applying applications such as quantitative proteomics to large-scale perturbation biology research is not a viable path.
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Advances have been made in the construction of microvascular stents
Time of Update: 2021-01-06
Three-dimensional vascular stent can guide the new microvascular vessels to blood supply to the flap area, but the previous three-dimensional stent because of its large size, low precision is difficult to meet the actual needs.
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Genetically modified autistic model monkeys make new achievements
Time of Update: 2021-01-06
"We hope to build a bridge with genetically modified autism model macaques and explore new ideas for clinical diagnosis of autism-related diseases through magnetic resonance imaging." to explore possible evolutionary conservative characteristics among primate species, the team boldly hypothesized that based on conservative brain region functions, the team constructed a model for the classification and prediction of mental illness that could migrate across species, Wang said.
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Keeping enough distance reduces the risk of new crown infections
Time of Update: 2021-01-06
a study published online in The Lancet, an international authoritative medical journal, said the combined analysis showed that keeping people at least 1 meter apart could help reduce the risk of contracting the new coronavirus, and that wearing protective equipment such as masks could also play a role.
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"Good medicine" becomes "poison" is actually the "pot" of intestinal bacteria.
Time of Update: 2021-01-06
, last year's study looked at the effects of different strains and 271 clinical drugs, examining how a single type of gut bacteria metabolized oral drugs.
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Research reveals new targets for slowing human stem cell aging
Time of Update: 2021-01-06
。 SIRT7 slows the aging of human-filled stem cells by inhibiting the LINE1-cGAS-STING pathline Sirtuins is a family of homogenetic proteins of the yeast Sir2 protein in mammals and a highly conservative class of deacetylases that are dependent on the evolutionary highly conservative NAD .
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The molecular mechanism of herpes virus immune escape and host natural immune regulation
Time of Update: 2021-01-06
Recently, Deng Hongyu, a researcher at the Institute of Biophysics in China, identified pPM1G, a host protein phosphatase PPM1G that negatively regulates the natural immune response mediated by STING and MAVS, and analyzed the molecular mechanism of the kaposi sarcoma-related herpes virus (KSHV) using the mesoglobin ORF33 to hold PPM1G for immune escape.
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The study provides new strategies to improve the effectiveness of clinical T-cell therapy
Time of Update: 2021-01-06
The team of Deng Liufu researchers from Shanghai Institute of Immunology has revealed the mechanism by which endogenous cGAS-STING signal promotes the action mechanism of T-cell anti-tumor immune response by maintaining the "dryness" of CD8-T cells, which provides a new strategy and basis for improving the effectiveness of clinical T-cell therapy.
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In-place regeneration of neurons is expected to treat Parkinson's disease
Time of Update: 2021-01-06
, a professor in the Department of Cell and Molecular Medicine at the University of California, San Diego, and his team spent nearly 15 years working with them to create a "simple" and effective new method of efficiently transforming astrological glial cells in the brain into functional neurons and reconstructing damaged neural circuits by inhibiting an RNA binding protein called PTB, which provides a powerful clinically viable way to treat neurodegenerative diseases.
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To study and analyze the new mechanism of double-folding of mouse monolithic stem cells
Time of Update: 2021-01-06
On June 4th, Researcher Shuai Shuai of Nanca University's National Key Laboratory of Pharmaceutical Chemistry Biology, in a paper published online in Stem Cell Report by Yu Yang, a researcher at The Third Hospital of Peking University, and Fan Yong, a researcher at the Third Hospital of Guangzhou Medical University, found that inhibition of apoptosis through gene regulation can reduce the double-folding of mouse monomatopenic embryonic stem cells in the process of daily culture and differentiation.
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For the first time, the high-resolution structure of de novo DNA methyl transferase and natural substrate nucleosomes was analyzed
Time of Update: 2021-01-05
The Xu Huaqiang Task Force of the Shanghai Drug Research Institute and the Peter Jones Task Force of the Wen'anlo Institute of the United States and the Karsten Melcher Task Force published the important research results entitled Structure of nucleosome-bound DNA methyltransferases DNMT3A and DNMT3B online on September 23, 2020 in the international top journal NATURE.
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Scientists describe the characteristics of neutral granulocytes from a single-cell scale
Time of Update: 2021-01-05
researchers performed neutral granulocyte separation and single-cell RNA sequencing on bone marrow, perennial blood and spleen in mice by optimizing experimental conditions, and combined bio-informational methods to establish a single-cell map of neutral granules under steady state conditions.
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Studies do not support the treatment of new crown infections with hydroxychloroquine and chloroquine
Time of Update: 2021-01-05
study, published online July 22 in nature, found no significant antiviral effects of chloroquine and hydroxychloroquine on new coronavirus infections in macaques or human lung cells.
The authors stress that studies to assess the drug activity of the new coronavirus should use cell line that can simulate lung tissue.
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The relationship between psoriasis and psoriasis arthritis and osteoporosis
Time of Update: 2021-01-05
Based on the non-attribution hypothesis, non-arthritis psoriasis patients are not a potential risk factor for bone reduction or osteoporosis because there is no secondary effect.
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The first case of new crown mother-to-child transmission has been confirmed
Time of Update: 2021-01-05
"" we provide a comprehensive case study that proves that in the last few weeks of pregnancy, the new coronavirus can pass through the placenta to the fetus, and that the newborn has neurological clinical symptoms associated with the new coronavirus infection.
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Study shows long-term depression can make people "stupid"
Time of Update: 2021-01-05
professor of neurology at Huashan Hospital, affiliated with Fudan University, According to Tuliptai, brain amyloid protein aggregation is AD in response to this situation, tulip thai research team
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"Starving" malaria parasites may help develop new antimalarial drugs
Time of Update: 2021-01-05
The study demonstrated the different composition structures of plasmodium falciparum's key protein for energy intake, the hetose transport protein PfHT1, in combination with natural substrate glucose and an inhibitor with weak inhibitor C3361, on the basis of which the team developed a series of selective inhibitors with higher affinity, laying the foundation for the further development of the series of antimalarial drugs.
