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Sansheng Guojian's RVO-related project completed the first phase II clinical trial and enrolled the first subject
Time of Update: 2021-07-22
The company is currently advancing clinical trials for 4 indications, namely: retinal vein occlusion (RVO), age-related macular degeneration (AMD), and diabetic macular degeneration Edema (DME), visual impairment caused by choroidal neovascularization in pathological myopia (pmCNV) .
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Under what circumstances will the iron in our body rise?
Time of Update: 2021-07-22
The researchers found that the dysregulation of macrophage-specific hepcidin is a key factor in the age-related iron overload of GOF PIEZO1 mice .
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Sansheng Guojian 601A ophthalmic RVO project completed the first subject enrollment
Time of Update: 2021-07-22
SH) announced today that the company's self-developed recombinant anti-VEGF humanized monoclonal antibody (R&D code: 601A) is currently undergoing "evaluation of 601A" (Ophthalmology) A multi-center, randomized, double-blind, positive drug-controlled phase II clinical trial on the safety and efficacy of patients with macular edema caused by branch retinal vein occlusion (BRVO)/central vein occlusion (CRVO) .
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Over the past two months, more than 30 pharmaceutical company executives have resigned, and the 67-year-old Asian richest man has resigned
Time of Update: 2021-07-22
Ma Jialie applied for the resignation of the company's deputy general manager, secretary of the board of directors and the positions of its subsidiaries due to personal reasons, and his application for resignation shall take effect from the date when the resignation report is delivered to the company's board of directors .
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Microbiome: Chinese scientists bring the world's first cross-population gene catalog, revealing the secret of "natural beauty"
Time of Update: 2021-07-22
Through the study of 822 skins of the Han population The samples were sequenced and combined with 538 North American samples, a relatively complete human skin microbial genome (iHSMGC) was constructed, and the composition and functional characteristics of the skin flora, the source and distribution of antibiotic resistance genes, and the correlation with Chinese skin characteristics were fully analyzed.
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Orphan drug research and development progress, 5 pictures to understand
Time of Update: 2021-07-22
Because of the small number of patients with rare diseases, low market demand, and high research and development costs, companies are not very enthusiastic about developing orphan drugs, but because all countries have introduced them A series of encouraging policies have been adopted.
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Always in a bad mood?
Time of Update: 2021-07-22
Recently, the University of Queensland researchers molecular biological science and the Institute of Brain Science Institute jointly in " Nature Communications " published an article entitled "GWAS of pepticulcer disease implicates Helicobacter pylori infection, other gastrointestinaldisorders and depression" the article proposes digestive Ulcer disease (PUD) and other gastrointestinal diseases may have a significant link with major depression (MD) .
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Be healthy and eat less sugar!
Time of Update: 2021-07-22
Support LPS-induced inflammation" article found that high fructose diet may cause inflammation of the immune system, and this inflammation can damage human cells and tissues, causing organs and body systems to fail to work properly, which may cause diseases .
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The influence of phosphate group on the drug-making properties of drugs
Time of Update: 2021-07-21
The following example demonstrates that the introduction of phosphate groups can improve the water solubility of drugs by means of structural modification .
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Galapagos releases mid-term clinical safety data for inflammatory bowel disease drug filgotinib
Time of Update: 2021-07-21
These two studies are evaluating the effect of the anti-inflammatory drug Jyseleca (filgotinib) on sperm parameters in male patients with inflammatory bowel disease (MANTA study) and rheumatic diseases (MANTA-RAy study) .
GALAPAGOS REPORTS PRIMARY ENDPOINT FOR THE ONGOING FILGOTINIB MANTA AND MANTA-RAy SAFETY STUDIES
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Still choosing a diet based on carbohydrate content?
Time of Update: 2021-07-21
Researchers found through analysis that a high glycemic index diet is associated with an increased risk of major cardiovascular events or death, and this correlation exists in subjects with or without a history of cardiovascular disease (hazard ratios of 1.
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The determination of the lead compound is by no means a simple "sieve activity"
Time of Update: 2021-07-21
It may not be directly developed as a new drug due to its shortcomings such as low activity, low selectivity, poor pharmacokinetic properties, or high toxicity, but it can undergo a series of structural modifications or modifications based on the structure of the compound , Get new drugs that meet the treatment requirements .
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Dezhan Health: VGX-3100 Project Phase III Trial Reached the Primary Endpoint and All Secondary Endpoints
Time of Update: 2021-07-21
The positive results of the first phase III clinical trial (REVEAL1) of the combination of the drug VGX-3100 and the device CELLECTRATM5PSP in the treatment of HPV-16/18-related high-grade cervical squamous intraepithelial lesions (HSIL), reached the clinical level in all evaluable subjects The primary endpoint of efficacy and all secondary endpoints .
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Biotech terminates clinical development of PD-1 monoclonal antibody and Trop2 antibody conjugate drug project
Time of Update: 2021-07-21
But recently, the company has carefully considered the subsequent development risks of the drug and decided to terminate the clinical trial of the project .
Regarding the company’s losses from terminating the above-mentioned projects, Biotech frankly, in addition to the BAT8003 project’s cumulative R&D investment of 61.
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Biotech suspends ADC and PD-1 research projects for hundreds of millions of yuan, only one drug is used to generate revenue
Time of Update: 2021-07-21
On February 8 this year, Biotech also announced the termination of the ADC project BAT8001 (recombinant humanized anti-HER2 monoclonal antibody-maytansine conjugate for injection) that has invested 226 million yuan in research .
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The new study found that men who are planning to become pregnant also need to supplement with folic acid, and the epigenetic changes in sperm will affect the health of offspring
Time of Update: 2021-07-21
Recently, a researcher from McGill University in Canada published an article entitled "Histone H3 lysine 4 trimethylation in sperm is transmitted to the embryo and associated with diet-induced phenotypes in the offspring" in the journal Developmental Cell , which proved the lack of Folic acid affects the trimethylation (H3K4me3) on the 4th lysine of histone H3 in sperm, and this change can be superimposed and transmitted to the embryo, leading to defects in the development of offspring .
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3.8 Goddess’ Day scientific research tells you why girls are always the hardest to coax those days
Time of Update: 2021-07-20
It turns out that women all over the world are at their lowest mood during the menstrual cycle these days, and not only emotions, but also heart rate, weight, and sexual behavior will have a greater impact .
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unprecedented! Nature: The world's first visualization of anti-tumor mechanism, revealing the whole process of "E3 ubiquitin ligase" against cancer cells
Time of Update: 2021-07-20
The study found that the human body There is a "SCF–RBR E3–E3" ubiquitin ligase super assembly in cells, which can connect ubiquitin to the F-box protein target, thereby resisting tumorigenesis.
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This most dangerous blood cancer is expected to be cured!
Time of Update: 2021-07-20
Recently, researchers from the Spanish Center for Genome Regulation (CRG) and the European Molecular Biology Laboratory (EMBL) published an article titled "Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell " in " Nature Communications " The article "transcriptomics" brings a new method of treating leukemia based on single-cell multi-omics, laying the foundation for people to find drugs to eliminate cancer from the source .
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After 30 years and covering 2 million people, Harvard University has found the most life-prolonging recipe: 160 grams of fruits and 240 grams of vegetables per day
Time of Update: 2021-07-20
The results of the analysis are consistent with the results of the separate analysis of the NHS and HPFS cohorts, suggesting that about 5 servings of fruits and vegetables per day, that is, 2 servings of fruits and 3 servings of vegetables, the participants have the lowest risk of death .
