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Cell: Aiming at two neurons controls visual behavior
Time of Update: 2021-02-09
When the mice linked visual stimuli to licking behavior, the researchers identified a collection of neurons in the mice's brains that responded to vertical stripes and re-stimulated them with a double photon laser.
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PNAS: Placental stem cells contribute to the regeneration process after heart disease
Time of Update: 2021-02-09
"They can target the injured area and go directly into the damaged area through the circulatory system to repair it, and they can avoid rejection by the host immune system." team at Mount Sinai has previously found that a mixture of placental stem cells in mice can help a pregnant female's heart recover from an injury that could lead to heart failure.
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Osteoarthritis stem cell therapy was accepted by CDE
Time of Update: 2021-02-08
November 9, Sibiman related person in charge of the introduction to the author, this is the first common type of isometric fat source stem cell products were accepted, but also Sibiman biology in China successfully obtained the third new drug acceptance.
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Gene editing technology can design new antibiotics
Time of Update: 2021-02-08
In a recent study, researchers at the University of Wisconsin-Madison and the University of California, San Francisco, used the gene-editing tool CRISPR to study specific antibiotic-targeted genes for clues about how to improve existing antibiotics or develop new ones.
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The latest gene therapy for chronic granuloma: restoring immunity to patients for up to 1 year
Time of Update: 2021-02-08
By proving for the first time that self-hematopoietic stem cell gene therapy can achieve long-term clinical benefits from consistent levels of functional nexual granulocytes, we hope that OTL-102 will provide x-CGD patients with a new treatment option that improves the quality and length of life and avoids chronic disease-related infections and inflammation.
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Mouse skin cells are converted into stem cells needed for embryonics
Time of Update: 2021-02-08
Israeli researchers report in a new issue of the American journal Cell-Stem Cells that they have successfully converted skin cells into the three main stem cells needed for early embryos in animal experiments, which can be differentiated into stem cells from tissues such as embryos, placenta and umbilical cords.
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The relationship between DNA packaging proteins and tumor development was found
Time of Update: 2021-02-07
a new study published in Nature Communications, a team led by Dr. Peter Mace of the Department of Biochemistry at the University of Otago revealed the three-dimensional structure of the proteins that control DNA packaging in the human body, BAP1 and ASXL1.
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Scientists have found that natural killer cells regulate anti-HIV antibody production
Time of Update: 2021-02-07
If we find a way for people to produce bnAbs before they become infected with HIV, they can suppress the HIV virus they encounter, and recently researchers from the Duke Institute for Human Vaccines have succeeded in finding an important protein that is highly active in people who produce bnAbs. The protein, called RAB11FIP5, involves changes in the distribution and function of natural killer cells, the first immune cells to respond to a viral infection.
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The use of anti-inflammatory drugs in surgery can improve the prognostication of cancer patients
Time of Update: 2021-02-06
The results of the world's first clinical study (SURGUVANT) to assess the improvement in the effectiveness of surgical treatment using anti-inflammatory drugs during surgery in colon cancer patients are published in BMC Cancer.
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Major breakthroughs have been made in the study of molecular 3D structure, which has brought new prospects for the development of new drugs
Time of Update: 2021-02-06
"Today, cross-coupled reactions are widely used in drug discovery, but they do not achieve 3D control of molecular structures.
Our team developed a new process to achieve this control, which allows for the selective formation of molecular mirroring.
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Relieves urinary frequency urgency Oral epinephrine-affected astigtor vibegron Phase 2 results were positive
Time of Update: 2021-02-06
Urovant Sciences recently announced that vibegron, an oral β-3 epinephrine-infested agonist developed by the company, has been positive in Phase 2 clinical trials for the treatment of bladder hyperactive disorder (OAB).
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Orchard's gene therapy, OTL-300, acquired from GlaxoSmithKline, was awarded priority drug eligibility by the European Union
Time of Update: 2021-02-06
EMA awarded OTL-300 PRIME based on data assessing preclinical and early clinical projects for the gene therapy to treat TDBT patients, including data collected from 9 patients in 10 patients in an ongoing proof-of-concept study.
addition to Strimvelis and OTL-300, the autologic gene therapy program in Orchard's pipeline includes products for primary immunodeficiency and neuro-metabolic disorders.
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It was found that the human lymphatic structure cells inhibited the function of T cells
Time of Update: 2021-02-06
Since each signaling path can be inhibited by drugs, cocktail therapy targeting inhibitors for these four mechanisms can completely reverse the immunosuppressive effects of FRCs.
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The most valuable anti-inflammatory drug in the study! AbbVie upadacitinib treats ulcerative colitis (UC) significantly induced clinically:
Time of Update: 2021-02-06
U.S. biotech giant AbbVie recently announced positive results of the new anti-inflammatory drug JAK1 selective inhibitor upadacitinib to treat ulcerative colitis (UC) in phase IIb/III clinical study U-ACHIEVE (NCT02819635) at the European Digestive Disease Week (UEG) in Vienna, Austria.
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New nanobots help with precise drug use at the bottom of the eye
Time of Update: 2021-02-06
The researchers put a liquid lubrication layer on the surface of the nanobot that mimics the pig cage grass, greatly reducing the adhesion of the biomass and allowing the robot to move in the glass body.
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Discover new ways to treat breast cancer
Time of Update: 2021-02-06
a study by Dr. Karolina Palucka, a professor at the Jackson Laboratory (JAK), and researchers at the Baylor Institute for Immunology, found that inflammation driven by IL1b (a member of the cytokine family of leptin 1) is commonly found in breast tumors, which may be an IL1 signal in metastatic breast cancer in women with HER2-negative.
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A new breakthrough in gene therapy! Successful treatment of mitochondrial gene mutation disease
Time of Update: 2021-02-06
findings suggest that gene repair using programmable nuclease-targeted mtDNA has the potential to become a gene therapy for various genetically-caused heterogeneic mitochondrial diseases.
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The researchers found molecules involved in the repair of liver damage
Time of Update: 2021-02-06
The method of regulating the sugar content in the blood of patients with type 2 diabetes is to inhibit the enzyme activity of CD26/DPP-4 through drugs.
authors also observed that specific removal of dead cells without liver damage also led to a significant increase in enzyme activity in CD26/DPP-4 in the blood.
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Gene therapy! Bluebird creature Lenti Globin has entered an official review in the European Union β for thalassemia
Time of Update: 2021-02-06
Bluebird Bio, a US gene therapy company, recently announced that the European Medicines Agency (EMA) has accepted applications for market approval (MAA) for gene therapy LentiGlobin to treat transfusion-dependent type β thrediotic anemia (TDT) and non-beta 0/beta genotype TDT adolescents and adult patients.
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EGFR mutation lung cancer first-line treatment of new options! Pfizer's second-generation targeted cancer drug Vizimpro has been approved by the FDA,..
Time of Update: 2021-02-06
OS data from key head-to-head III studies are very encouraging, with the mid-OS in patients treated with Vizimpro's EGFR-activated mutant NSCLC approaching 3 years, a significant improvement over the current clinical first-line treatment, Iressa.
