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Arthritis Rheumatol: Disease onset and reaction of patients with rheumatism and musculoskeletal diseases after being vaccinated with the new crown mRNA vaccine
Time of Update: 2021-08-26
It can be seen that it is not common for RMD patients to have seizures after being vaccinated with the new crown mRNA vaccine .
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New revelation from TICOSPA research: axSpA standard treatment, is it a reality or a utopia?
Time of Update: 2021-08-23
In addition, imaging results, patient comorbidities and other factors should be considered [3]; on the other hand, there is still a lack of There is no absolute consensus reference for target setting that can effectively prove that the efficacy of standard treatment is significantly better than that of conventional treatment .
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First revealed the secret: different ways of increasing methotrexate have a big PK, who is better?
Time of Update: 2021-08-23
Increase the initial dose + rapid increment, can better optimize the MTX monotherapy?
At 8 weeks and 16 weeks, there was no significant difference in the proportion of patients who achieved a good EULAR response in the rapid and conventional increment groups .
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Asymptomatic hyperuricemia, why do you recommend lowering uric acid?
Time of Update: 2021-08-23
102) published a real-world retrospective cohort study to explore the "influence of asymptomatic hyperuricemia control of uric acid levels on gout attacks.
Study Design The study was based on the data from the JMDC database from April 2012 to June 2019, and included subjects with at least one blood uric acid level (sUA) ≥8.
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Two Science+Cell papers reveal that plant immune receptors act as calcium channels to regulate immunity
Time of Update: 2021-08-21
Two research papers published by Science and Cell revealed that CNL and RNL two types of immune receptors act as the molecular mechanism of calcium ion channels to activate immune response .
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EULAR Express: How to choose first-line and second-line options for the treatment of AS with biological agents?
Time of Update: 2021-08-21
The results show that IL-17i is more commonly used in third-line or later treatment options than TNFi (that is, patients have used two or more biological agents when they initiate IL-17i therapy) (Figure 6) .
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Single-base editing company Beam and Apellis collaborate to develop gene editing therapies for complement diseases
Time of Update: 2021-08-21
Written | Edited by Wang Cong | Nagashi Typesetting | Shuichengwen A few days ago, Beam Therapeutics announced a collaboration with Apellis Pharmaceuticals to create new gene editing therapies for complement-driven diseases, a type of disease caused by overactive immune system .
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Small problems such as dry mouth and dry eyes may also be a sign of a serious illness?
Time of Update: 2021-08-19
Other treatments: including the biological agent rituximab, may be effective for some patients with connective tissue disease-related interstitial pneumonia who are severely or rapidly progressing, but need to pay attention to whether there are respiratory infections .
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Cell host immune system regulates homeostasis and inflammation through the interaction of endogenous virus group and exogenous microorganisms
Time of Update: 2021-08-18
On June 23, 2021, the Yasmine Belkaid team from the National Institutes of Health published an article entitled Endogenous retroviruses promote homeostatic and inflammatory responses to the microbiota in Cell.
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Panoramic view of the epigenome and transcription of immune cells induced by Cell influenza vaccine
Time of Update: 2021-08-18
By clustering and analyzing mDCs and classical monocytes using H3K27ac, H2BK5ac, H4K5ac, H3K9ac, and PADI4 markers, the researchers constructed a single-cell histone modification panorama and found that the cells on day 180 did not return to the baseline position.
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Ann Rheum Dis: Efficacy and safety of brodazumab on axial spondyloarthritis
Time of Update: 2021-08-14
Secondary endpoints included changes in the ASAS20 response rate and C-reactive protein-based ankylosing spondylitis disease activity score (ASDAS-CRP) and safety at week 16 .
Secondary endpoints included changes in the ASAS20 response rate and C-reactive protein-based ankylosing spondylitis disease activity score (ASDAS-CRP) and safety at week 16 .
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JAHA: Analysis of the effect of colchicine treatment in patients with coronary artery disease
Time of Update: 2021-08-14
It can be seen that in CAD patients, colchicine can reduce the risk of myocardial infarction and stroke, but the incidence of gastrointestinal discomfort is higher, and it has no effect on all-cause mortality .
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Ann Rheum Dis: Impaired fertility in men with inflammatory arthritis
Time of Update: 2021-08-14
Impaired fertility in men diagnosed with inflammatory arthritis: results of a large multicentre study (iFAME-Fertility) .
com/content/early/ 2021/08/02/annrheumdis-2021-220709Impaired fertility in men diagnosed with inflammatory arthritis : results of a large multicentre study (iFAME-Fertility) in this message
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NEJM: CRISPR-Cas9 in vivo gene editing to treat transthyretin amyloidosis
Time of Update: 2021-08-14
After conducting pre-clinical in vitro and in vivo studies, researchers aim to evaluate a single escalating dose of NTLA-2001 in 6 patients with hereditary ATTR amyloidosis with polyneuropathy In terms of safety and efficacy, there are 3 subjects (0.
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Arthritis Rheumatol: Evaluation of immune response and disease status in SLE patients after being vaccinated with SARS-CoV-2
Time of Update: 2021-08-14
Researchers aim to evaluate the serum reactivity and disease onset of patients with multi-ethnic systemic lupus erythematosus (SLE) after vaccination with COVID-19 .
Overall, the fully vaccinated SLE patients produced significantly lower IgG antibodies against the SARS-CoV-2 spike RBD than the control group .
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Colloids and Surfaces B: MTX+HCQ nanomicelles are three times more effective than traditional drug delivery methods
Time of Update: 2021-08-14
Our results show that, compared with the control, measuring two kinds of test concentrations of osteoclastogenesis showed a dose-dependent decreaseExpose monocytes in human peripheral blood to nanomicelles formed by the combination of two different concentrations of methotrexate and hydroxychloroquine (127-Pluronic-HCQ-MTX nanomicelles), 20 ug/mL HCQ and 074 ng/mL MTX and 70 ug/mL HCQ and 2.
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Ann Rheum Dis: Hormone reduction trajectory in patients with rheumatoid arthritis combined with csDMARD
Time of Update: 2021-08-14
An article recently published in Ann Rheum Dis, a leading journal of rheumatology, described the dynamic trajectory and characteristics of GC reduction and drug withdrawal in RA patients after starting GC combined with conventional synthetic disease improving antirheumatic drugs (csDMARDs) .
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Vaccine mixing is more effective?
Time of Update: 2021-08-14
Recently, the Danish National Serum Institute (SSI) pointed out that after the first dose of AstraZeneca's new crown vaccine, the second dose of Pfizer/BNT or Moderna's mRNA vaccine can produce "good protection.
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Mingzhao Zhu and Xiaoqun Wang's research team collaborated to identify the key vascular endothelial cells that regulate T cell thymic emigration
Time of Update: 2021-08-12
The researchers also further studied the developmental homeostasis of eTPEC and the cellular and molecular regulation mechanisms of mature T cell thymus emigration .
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Compare the three major guidelines for lupus erythematosus and see the Asia-Pacific management consensus
Time of Update: 2021-08-12
European guidelines: To achieve clinical remission or low disease activity in all organs, and prevent recurrence, use the smallest dose of hormones as possible to maintain treatment; when lupus relapses, treatment should be adjusted according to the severity of the involved organs, including increasing the dose of existing drugs and changing the dressing Or add new drugs .
