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ARD: To evaluate the efficacy and safety of Taltz (ixekizumab) and adalimumab in the treatment of patients with psoriatic arthritis
Time of Update: 2021-09-10
Results: The proportion of patients who took IXE and ADA reached ACR50 and PASI100 (39% vs 26%, p<0.
Results: The proportion of patients who took IXE and ADA reached ACR50 and PASI100 (39% vs 26%, p<0.
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Semin Arthritis Rheu: The prognosis of rheumatoid arthritis patients infected with the new crown
Time of Update: 2021-09-10
The mortality rate of the RA cohort, hospitalization rate, ICU occupancy rate, mechanical ventilation, severe COVID-19, acute kidney injury, renal replacement therapy/hemodialysis, acute respiratory distress syndrome-ARDS, ischemic stroke, venous thromboembolism-VTE, and sepsis risk are higher than those of non-RA Patients with new crowns are higher than non-RA patients with new crowns.
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Ann Rheum Dis: Polygenic risk score has high diagnostic value for ankylosing spondylitis
Time of Update: 2021-09-03
And compared the distinguishing ability of PRS with other widely used diagnostic methods, including C-reactive protein (CRP), HLA-B27, and sacroiliac joint MRI .
And compared the distinguishing ability of PRS with other widely used diagnostic methods, including C-reactive protein (CRP), HLA-B27, and sacroiliac joint MRI .
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JAMA Surg: Surgery combined with adalimumab for the treatment of moderate to severe hidradenitis suppurativa
Time of Update: 2021-09-03
At week 12, 49 of 103 patients in the adalimumab treatment group achieved clinical response to HS in all parts of the body, while only 35 patients in the placebo group (48% vs 34%) .
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Continuous fever, rash does not go away...Beware of adult Still's disease
Time of Update: 2021-09-03
is it serious?What is adult Still's disease?Adult Still's disease is a group of syndromes whose main manifestations are high fever, arthralgia (inflammation), skin rash, and elevated white blood cells , and the etiology and pathogenesis are not yet clear.
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Ann Rheum Dis: Comparison of the efficacy of tofacitinib and baritinib in the treatment of rheumatoid arthritis
Time of Update: 2021-09-03
These patients were more likely to have received multiple biological disease-modifying anti-rheumatic drugs (bDMARDs) and TOFA treatment before using JAK inhibitors .
These patients were more likely to have received multiple biological disease-modifying anti-rheumatic drugs (bDMARDs) and TOFA treatment before using JAK inhibitors .
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Rheumatoid arthritis pain is unbearable?
Time of Update: 2021-09-03
Osteoporosis Proper active and passive movement of joint muscles is the fundamental measure to maintain the normal range of motion of the joints .
Proper active and passive movement of joint muscles is a fundamental measure to maintain the normal range of motion of joints .
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Still afraid of kidney puncture? Be careful to miss the opportunity to stop the drug
Time of Update: 2021-09-03
If the proteinuria treatment of butterfly friends for more than 3 months, the large urine protein index still does not decrease significantly , a renal puncture can be considered to determine whether it is lupus nephritis and its pathological type .
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Arthritis Rheumatol: Analysis of the incidence of psoriatic arthritis in patients receiving biotherapy for psoriasis
Time of Update: 2021-09-03
The study showed that the risk of psoriatic arthritis in psoriasis patients receiving biologic drug treatment was significantly reduced both statistically and clinically .
The risk of psoriatic arthritis in patients with psoriasis receiving biologic drug treatment is statistically and clinically significantly reduced .
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Explore the stem cell treatment of systemic lupus erythematosus
Time of Update: 2021-08-27
Stem cells significantly improve the clinical and serological performance of patients through immune regulation, reconstruct a healthy immune system, and SLE disease activity is satisfactorily controlled; in addition, stem cells also reverse multiple organ dysfunctions, and proteinuria and serum autoantibody titers are reduced .
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Arthritis Rheumatol: Efficacy and safety of anakinra in the treatment of gout attacks
Time of Update: 2021-08-27
Comparing anakinra element (100 or 200 is mg / day for 5 days) and triamcinolone acetonide (single injection of 40 mg ) of the pros and cons, the primary endpoint from baseline 24-72 hours to assess the patient's affected joint pain Intensity changes (use a visual analog scale score of 0-100 ) .
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Imaging features of rheumatoid arthritis-related interstitial lung disease
Time of Update: 2021-08-27
Blood vessel High-resolution CT ( HRCT ) should be performed for almost all patients whose symptoms, pulmonary function results, or abnormal chest radiographs suggest diffuse parenchymal lung disease .
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Ann Rheum Dis: Fatigue predictors for rheumatoid arthritis patients receiving targeted therapy
Time of Update: 2021-08-27
Low objective disease activity and high PGA at baseline were predictors of clinically relevant fatigue at 24 months .
Lower objective disease activity and high PGA at baseline are predictors of clinically relevant fatigue at 24 months .
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"Polyvasculitis under the microscope" is hard to prevent, so be careful!
Time of Update: 2021-08-27
thrombusHow to treat polyangiitis under the microscope?How to treat polyangiitis under the microscope?The treatment of the disease can be divided into three stages, namely the induction period, the maintenance remission period and the treatment of relapse .
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Is there a risk of bleeding with long-term use of aspirin and low-molecular-weight heparin?
Time of Update: 2021-08-27
Clinical observation of aspirin combined with low molecular weight heparin in the treatment of 30 cases of habitual abortion with antiphospholipid syndrome .
Clinical observation of aspirin combined with low molecular weight heparin in the treatment of 30 cases of habitual abortion with antiphospholipid syndrome .
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Significance of positive rheumatoid factor in rheumatoid arthritis
Time of Update: 2021-08-27
Studies have shown that, compared with the high titre ACPA, high titers of RF seems to be more predictive of severe disease course, with interstitial lung disease and vascular performance is more relevant go far outside the joint .
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Choice of uric acid-lowering drugs for patients with gout
Time of Update: 2021-08-27
For gout patients with hypertension or hyperlipidemia, XOI can also be combined with one of the following mild uric acid excretion drugs: Losartan ( combined with hypertension ), Fenofibrate ( combined with hypertriglyceridemia ) , atorvastatin ( the only urate lowering effect of statins, as the case for high cholesterol hyperlipidemia, or for cardiovascular events in the secondary prevention ) .
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NEJM: CAR-T cell therapy successfully treats lupus erythematosus for the first time
Time of Update: 2021-08-27
The research team performed CAR-T cell therapy on a 20-year-old female patient with severe systemic lupus erythematosus.
This study shows that CAR-T cell therapy targeting CD19 can induce rapid remission of refractory systemic lupus erythematosus .
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Immune checkpoints and autoimmune diseases
Time of Update: 2021-08-26
ICP Targeted Therapy of Autoimmune Disease Research Progress Soluble ICP Ligand and Receptor Soluble ICP Ligand and ReceptorSource Reference 1Source Reference 1In 2006, Abatacept was first approved for the treatment of RA.
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Drug use during pregnancy in patients with rheumatoid arthritis
Time of Update: 2021-08-26
1. Drugs with a moderate to high risk of fetal harm During conception and pregnancy, the use of drugs with a higher or unknown risk of causing birth defects should be avoided .
