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Rheumatology: Urine protein can predict the response to active lupus nephritis and rituximab treatment
Time of Update: 2021-09-29
Serum LPGDS (A), transferrin (B), AGP-1 (C), ceruloplasmin (D), monocyte chemoattractant protein-1 (E) and soluble vascular cell adhesion molecules in patients with systemic lupus erythematosus- 1(F) level analysis .
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ARD: Peripheral blood megakaryocytes expand in rheumatoid arthritis, systemic lupus erythematosus, and primary Sjogren’s syndrome
Time of Update: 2021-09-29
Shantou University Medical College Guohong Zhang team analyzed data from 119 (one untreated patients 41 RA , 38 pSS , 28 SLE and 12 months from multiple autoimmune) and 20 healthy control PBMC of RNA-seq data, do biological Process and transcription factor enrichment and immune cell type analysis based on deconvolution .
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Study on the relationship between autoimmune and inflammatory diseases and intestinal microbes
Time of Update: 2021-09-29
Decreased bacterial diversity is related to disease activity In addition, the antibodies and T cells of patients with systemic lupus erythematosus recognize bacterial antigens from the oral, intestinal, and skin microflora, including Propionibacterium propionicum and Bacteroides .
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What is the risk of myocardial infarction and nephritis in patients with systemic lupus erythematosus who smoke?
Time of Update: 2021-09-29
In the duplicate cohort, it was verified that carrying STAT4 susceptibility alleles was associated with increased risk of myocardial infarction (OR 6.
Smoking SLE patients with STAT4 susceptibility alleles seem to increase the risk of myocardial infarction and nephritis .
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Arthritis Rheumatol: Phase II randomized trial of rituximab + cyclophosphamide + belimumab in the treatment of lupus nephritis
Time of Update: 2021-09-29
In a multicenter, randomized, open-label clinical trial, 43 patients with relapsed or refractory LN received rituximab, cyclophosphamide (CYC) and glucocorticoid treatment, followed by weekly infusion of Bailey Lumumab until the 48th week (RCB group), or use rituximab and CYC but not belimumab (RC group) .
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Eur Heart J: Anti-interleukin-1 drugs for the treatment of pericarditis
Time of Update: 2021-09-29
It can be seen that anti-IL-1 drugs seem to be the most important development in the treatment of recurrent pericarditis in the past 5 years .
Anti-IL-1 drugs seem to be the most important development in the treatment of recurrent pericarditis in the past 5 years .
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JCEM: Changes of serum cytokines in women with polycystic ovary syndrome during pregnancy
Time of Update: 2021-09-29
PCOS pregnant women (n=358) and non-PCOS pregnant women (n=258, control group) provided 1752 serum samples at four time points (10th, 19th, 32nd, and 36th weeks) during pregnancy .
Changes in serum cytokines throughout pregnancy in women with polycystic ovary syndrome .
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ARD: Are the B cells of patients with chronic cutaneous lupus erythematosus the same?
Time of Update: 2021-09-29
CCLE is immunologically heterogeneous, including a part of B cell composition like SLE , and its clinical manifestations are also related to increased levels of autoantibodies and more extensive skin damage Source:Jenks SA, Wei C, Bugrovsky R, Hill A, Wang X, Rossi FM, Cashman K, Woodruff MC, Aspey LD, Lim SS, Bao G, Drenkard C, Sanz I.
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HLA-B27 positive = ankylosing spondylitis?
Time of Update: 2021-09-29
,According to the expression characteristics of HLA-B27, common methods used for clinical detection include MLCT Assay, double antibody sandwich enzyme-linked immunosorbent assay (ELISA), magnetic bead enzyme-linked immunoassay (IMS-ELISA), Flow cytometry analysis method (FCM), polymerase chain reaction-sequence specific primer method (SSP-PCR) and real-time fluorescent PCR (qPCR) method, etc.
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This article understands the dermoscopic differentiation of scalp psoriasis and seborrheic dermatitis
Time of Update: 2021-09-29
A retrospective, observational studies showed scalp psoriasis skin most prominent feature is the red dot mirror ball and red, red ring twisted and glomerular -like vascular .
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Innovation strategy, sharing and opening Zhangjiang Life Science International Innovation Summit is about to open
Time of Update: 2021-09-29
The summit is based in Zhangjiang, facing the world, focusing on new technologies, new models, new fields, and new trends in cross-industry integration in the life science industry, integrating functions such as "forums, exhibitions, releases, and docking exchanges" to cultivate and build into a global landmark.
And a leading international conference on the life science industry .
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Arthritis & Rheumatology: Effect of discontinuation of denosumab on patients with rheumatoid arthritis treated with glucocorticoids
Time of Update: 2021-09-29
In an analysis of short-term use of denosumab in subjects with rheumatoid arthritis receiving glucocorticoids , it was found that the withdrawal of denosumab gradually increased bone turnover, and the bone mineral density of the lumbar spine and total hip returned to baseline levels .
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Arthritis Rheumatol: The relationship between urinary matrix metalloproteinase 7 and the pathogenesis of lupus nephritis
Time of Update: 2021-09-29
Figure 2 The increase of uMMP7 level during biopsy is related to the enhancement of LN renal histological activity; (A) Representative images of biopsy of LN patients showed active renal disease by PAS staining (Phase I trial cohort, n=88) .
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EULAR/ERA-EDTA 2019: new developments in recommendations for the treatment of lupus nephritis
Time of Update: 2021-09-29
Adjuvant treatment for patients with lupus nephritis The renin-angiotensin-aldosterone system blocker (in non-pregnant patients) is recommended because it has anti-proteinuria and hypotensive effects ; it should be used with caution in patients with impaired renal function .
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3 minutes to show you how to use methotrexate safely
Time of Update: 2021-09-29
However, due to the toxic effect of methotrexate, even if the dose is kept low, long-term use will cause many adverse reactions, such as vomiting, nausea, diarrhea, bone marrow suppression, liver insufficiency, renal failure, pancytopenia, and pulmonary symptoms And skin ulcers .
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ARD: New interleukin 6 monoclonal antibody Olokizuma combined with methotrexate for rheumatoid arthritis patients with poorly controlled methotrexate monotherapy: the results of a randomized controlled phase III study evaluating efficacy and safety
Time of Update: 2021-09-29
1136/annrheumdis-2021-219876Nasonov E, Fatenejad S, Feist E , et al Olokizumab, a monoclonal antibody against interleukin 6, in combination with methotrexate in patients with rheumatoid arthritis inadequately controlled by methotrexate: efficacy and safety results of a randomised controlled phase III study Annals of the Rheumatic Diseases Online First Published: 03 August 2021.
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For rheumatoid treatment, you can't miss these 6 Chinese herbal medicines, especially the first one, which is the main medicine for eliminating evil.
Time of Update: 2021-09-29
Traditional Chinese medicine commonly used to treat rheumatoid arthritis 0 1 Tripterygium wilfordii(Image source: network )(Image source: network )Tripterygium wilfordii, also known as yellow vine, is cold in nature, bitter, pungent, and poisonous .
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Arthritis & Rheumatology: Nintedanib in the treatment of patients with systemic sclerosis-related interstitial lung disease: subgroup analysis based on autoantibody status and skin score
Time of Update: 2021-09-28
Although the decline of FVC in patients with SSc-ILD is still difficult to predict, nintedanib is effective in reducing the annual progression rate of ILD in each subgroup according to baseline ATA status, SSc subtype and mRSS .
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Sjogren's syndrome?
Time of Update: 2021-09-19
Liqihuoxue - gu, Taichong gu gu(Image source: network)(Image source: network)Hegu has the effect of promoting qi and blood circulation, helps to promote the dispersion of body fluid, moisturizes the whole body, and plays a positive role in the treatment of dry eye .
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Traditional Chinese medicine compound can effectively delay the progression of rheumatoid and improve the prognosis of patients
Time of Update: 2021-09-19
Rheumatoid arthritisRecently, Professor Huang Runyue's team from Guangdong Provincial Hospital of Traditional Chinese Medicine published a paper "Systematic Evaluation of the Effects of Chinese Herbal Compounds Treating Rheumatoid Arthritis on Rheumatoid Factor and Anti-cyclic Citrullinated Peptide Antibodies " in the internationally renowned journal "Frontiers in Pharmacology" (IF: 5.
