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Nature Reviews Immunology summarizes how nucleic acid-sensing Toll-like receptors correctly distinguish between host and exogenous nucleic acid?
Time of Update: 2021-10-02
, Including compartmentalization, ligand availability, receptor expression, and signal transduction, introduced the major advances in the regulatory mechanism of nucleic acid-sensing TLRs in the past decade, and pointed out many outstanding issues that still exist .
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Why has the spread of new crown mutants increased?
Time of Update: 2021-10-02
Since December 2019, the new crown virus has spread to 223 countries around the world, with more than 210 million infections and more than 4. 44 million deaths. It has become the world's largest hea
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How to evaluate the disease activity of psoriatic arthritis?
Time of Update: 2021-10-02
With the support of complex and chaotic clinical manifestations, the clinical evaluation of PsA disease activity needs to cover the following: evaluation of tenderness and swelling of joints; evaluation of skin and nails; evaluation of enthesitis and finger inflammation; evaluation of the spine if necessary; patient description The disease activity, physical function and quality of life.
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"Nature Review: Rheumatology" Chinese Abstracts, Issue 1, 2020
Time of Update: 2021-10-02
In this review, we discussed the history, pharmacodynamics, clinical indications and new uses of mycophenolate mofetil, azathioprine and tacrolimus in rheumatism .
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Smoking and diabetes are protective factors for osteoarthritis | APLAR 2021
Time of Update: 2021-10-02
According to SCHS, risk factors for TKR in KOA patients include BMI, physical activity> 5h/w, gout, and more children.
This study used SCHS as the data source to analyze the risk factors of TKR in KOA patients .
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Immunity | Central South University Hu Zhuowei/Xiao Yang discovers new potential therapeutic targets for pulmonary fibrosis
Time of Update: 2021-10-02
On August 17, 2021, Central South University Hu Zhuowei and Xiao Yang jointly published a research paper entitled "The chemokine CCL1 triggers an AMFR-SPRY1 pathway that promotes differentiation of lung fibroblasts into myofibroblasts and drives pulmonary fibrosis" in Immunity.
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How does the cell body avoid autoimmune diseases?
Time of Update: 2021-10-02
Germain's research team from the Immune System Biology Laboratory of the National Institute of Allergy and Infectious Diseases published a report on Cell entitled A local regulatory T cell feedback circuit maintains immune homeostasis by pruning self-activated T cells Research articles have confirmed the existence of a set of negative feedback regulation loops that limit autoimmune response in the body, and clarified its specific regulation mechanism .
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Cell 820,000 GWAS meta analysis reveals the genetic risk of osteoarthritis and new drug targets
Time of Update: 2021-10-02
The GWAS meta-analysis of the cohort emphasized the influence of joint location types on the characteristics of genetic risk variation and the link between osteoarthritis genetics and pain-related phenotypes, and pointed out potential targets for therapeutic intervention .
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HD GIF-Immune War in the Human Body
Time of Update: 2021-10-02
Immune wars are taking place in the human body at all times-human loyal guards are constantly removing the diseased, aging and necrotic cells that may appear in the human body .
5. Immune cells can pass through blood vessels.
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Immunity Jin Jin/Cao Qian collaborate to analyze the mechanism of selenium deficiency in Crohn’s disease that leads to T cell differentiation disorder
Time of Update: 2021-10-02
In-depth mechanism studies have shown that in Th1 cells, selenium mainly regulates one-carbon metabolism through selenoprotein W (SELW) and the purine salvage pathway mediates the removal of reactive oxygen species (ROS) in the cytoplasm, thereby affecting NF -Activation of κB signaling pathway inhibits the production of IFN-γ .
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[Olink Black Technology] Cell's new work reveals the secret of diet-intestinal flora-the mystery of the human immune system
Time of Update: 2021-10-02
Using multi-omics measurements of host parameters including the microbiome and Olink proteome, including the most advanced sequencing and Olink PEA immuno-inflammatory factor analysis technology, we found that high-fiber and high-fermented food intake affects the microbiome and Human biology .
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With these skin manifestations of rheumatism, the kidneys may also be implicated.
Time of Update: 2021-10-02
Figure 1 SLE facial butterfly plaque ■ Systemic sclerosis (SSc) renal involvement is very common in patients with SSc, but most of them are independent of SSc, such as mild urine protein, elevated blood creatinine, and hypertensive nephropathy.
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Nat Immunol Hu Wei/Wang Zhongmin reveals the dynamics and functions of Treg in the inflammatory response
Time of Update: 2021-10-02
Although clinical trials based on Treg cell transplantation have shown that Treg has a certain alleviating and therapeutic effect on autoimmune diseases, many studies still show that under the influence of strong immune response and related inflammatory factors in the inflammatory response microenvironment, Treg It may lose the expression of Foxp3 and lose its immunosuppressive function, which may promote immunopathology during infection .
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Research by Dr. Pan Youdong of Xinhe Biologics reveals the efficient delivery and mechanism of new vaccines
Time of Update: 2021-10-02
The study reported the high-efficiency protection and safety of the modified Ankara vaccinia vaccine in vivo, and revealed the superiority of vaccination of the modified Ankara vaccinia vaccine through skin scratching, and analyzed its molecular mechanism through gene expression profiles, and further explored its application to lung infections.
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A mild infection of the mother can improve the immunity and inflammatory response in the offspring｜Science Weekly Selection
Time of Update: 2021-10-02
The authors found that the increased concentration of the pro-inflammatory cytokine interleukin-6 (IL-6) produced by the mother due to infection can cause epigenetic changes in the development of fetal intestinal epithelial stem cells in the uterus .
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Frontier｜Treat Rheumatoid Arthritis, CRISPR Editing "Smart Cells" Shows Therapeutic Potential
Time of Update: 2021-10-02
▲The principle of the treatment plan (picture source: reference [1]) Professor Farshid Guilak, the corresponding author of the paper, explained, “We used CRISPR technology to re-edit the genes in the stem cells, and then by seeding the cells on the braided scaffold, Created a small cartilage implant and placed it under the skin of the mouse .
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[Science] Heavy!
Time of Update: 2021-10-02
Last year, researchers at Charretti Berlin Medical University and the Max Planck Institute for Molecular Genetics were shocked to discover that some people who have not been infected with the new coronavirus actually have immune memory cells that can help them recognize the new coronavirus, and These scientists reported this discovery for the first time .
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How to treat skin lupus erythematosus?
Time of Update: 2021-10-02
4) Tretinoin drugs are recommended as the second-line treatment of refractory CLE (especially hyperkeratotic skin lesions and verrucous lupus erythematosus), preferably combined with antimalarials .
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Nat Immunol Liu Zheng/Yu Di collaborated to report that daily dietary selenium supplementation can enhance humoral immune response by inhibiting iron death of TFH cells
Time of Update: 2021-10-02
On the contrary, daily dietary selenium supplementation can up-regulate the selenoprotein GPX4, protect TFH cells from iron death, and enhance antibody immune response .
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STTT Shandong University Gao Chengjiang's team discovered the key role of TRIM31 in antifungal immunity
Time of Update: 2021-10-02
Therefore, the lack of Trim31 in bone marrow-derived dendritic cells (BMDC) and macrophages (BMDM) inhibits SYK-mediated signal transduction and inhibits pro-inflammatory cytokines and chemokines against the fungal pathogen Candida albicans infection Secretion .
