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For the clinical use of febuxostat, these 5 points are enough!
Time of Update: 2021-10-10
) under the guidance of a doctor* For the prevention of gout treatment of early onset of prevention , recommends that small dose and gradually increase the amount , , and the use of colchicine and nonsteroidal anti-inflammatory drugs (such as ibuprofen, etc.
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Arthritis & Rheumatology: Signal factors: From angiogenesis to inflammation in rheumatoid arthritis
Time of Update: 2021-10-10
By RA the ECs found in gene expression profiles of three classes and 4 classes as a prime signal RA is a potential candidate biomarkers and therapeutic targets .
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ARD: A case series of SARS-CoV-2 booster doses for patients with autoimmune diseases
Time of Update: 2021-10-10
The humoral response of 89% of the participants increased after the booster vaccination, and the median anti-spike protein antibody was 2500 (IQR 885 – 2500 U/mL) .
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Diabetes Obes Metab: The relationship between empagliflozin and uric acid metabolism in diabetic patients
Time of Update: 2021-10-10
The researchers used a mixed linear model to evaluate the effects of empagliflozin and placebo on UA concentrations, and a Cox proportional hazard model to study the composite outcome of anti-gout drugs or gout attacks .
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Oral ulcers are not so simple!
Time of Update: 2021-10-10
The appearance of ulcers on the oral mucosa can be a common manifestation of many diseases, which requires analysis and differential diagnosis based on medical history, clinical manifestations and a series of examinations .
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Age-related changes in B cell function and differentiation lead to female bias in lupus mouse models
Time of Update: 2021-10-10
in conclusion:Conclusion: Conclusion: Age-related B cells ( ABCs ) have gender differences in function and differentiation, and play an important regulatory role in antiviral responses and autoimmune diseases .
Age-related B cells ( ABCs ) have gender differences in function and differentiation, and play an important regulatory role in antiviral responses and autoimmune diseases.
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B cell AIM2 deficiency can improve systemic lupus erythematosus by regulating Blimp-1-Bcl-6-mediated B cell differentiation
Time of Update: 2021-10-10
The study found that AIM2 is highly expressed in B cells of patients with lupus , and promotes B cell differentiation by regulating Bcl-6 - Blimp-1 , providing a new target for the treatment of systemic lupus erythematosus .
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Sub-Journal of Nature: Site-specific PEGylation of interleukin 2 enhances immunosuppression through continuous activation of regulatory T cells
Time of Update: 2021-10-10
Subcutaneous injection of different doses of PEGylated IL-2 induces continuous activation and expansion of Treg cells by highly selective binding to the trimeric IL-2R , which can enhance lupus, collagen-induced arthritis and graft-versus-host mice The disease treatment effect of the model does not damage the host 's immune defense against viral infections .
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Dry eyes and can't relieve themselves?
Time of Update: 2021-10-10
The cause of dry eye is complex, combined with the overall concept of the motherland medicine and the principles of syndrome differentiation, experts believe that its pathogenesis is related to the function of the internal organs, qi, blood and body fluid, and the movement of meridians .
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Nature Immunology Li Bin/Tong Xuemei/Wang Gang found that insulin signaling establishes the developmental trajectory of fat regulatory T cells
Time of Update: 2021-10-02
In terms of mechanism, the study found that insulin signaling occurs through the HIF-1α-Med23-PPAR-γ axis to drive the conversion of CD73hiST2lo into CD73loST2hi adipose Treg cell subsets .
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Immunity Zhejiang University Jin Jin/Cao Qian discovered selenium as a potential treatment for patients with Crohn's disease
Time of Update: 2021-10-02
On August 2, 2021, Jin Jin and Cao Qian of Zhejiang University jointly published a research paper entitled "Multiomics analyses reveal a critical role of selenium in controlling T cell differentiation in Crohn's disease" in Immunity.
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Which one is better for diagnosing SLE?
Time of Update: 2021-10-02
After reviewing the sensitivity and specificity of different standards, Professor Aringer pointed out that 2019 EULAR/ACR is the best diagnostic classification standard for SLE so far.
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[Nature Sub-Journal] Complex tissue memory T cells are expected to create the future for immunotherapy and vaccine research and development!
Time of Update: 2021-10-02
For example, if you want to treat the new crown or Influenza and other respiratory viruses produce effective TRM cell-mediated immunity, you need to induce TRM cells in the lungs .
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Why did the structural progress of axSpA trigger heated discussions?
Time of Update: 2021-10-02
A number of previous studies have shown that the efficacy of TNF-α inhibitors in delaying structural progress is not satisfactory: under continuous treatment, although the inflammation is well controlled, the fat deposits still increase significantly in the course of the disease[22-25] .
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Dr. Zhu Huifang from Gannan Medical College published a review of the latest research progress of PARPs in innate immunity
Time of Update: 2021-10-02
Zhu Huifang from the First Affiliated Hospital of Gannan Medical College was invited to publish a review paper titled: When PARPs Meet Antiviral Innate Immunity in Trends in Microbiology.
This article focuses on the regulatory functions of PAPRs family members in the antiviral innate immune signal pathway .
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How to manage SLE pregnancy?
Time of Update: 2021-10-02
Exciting content such as pregnancy management of systemic lupus erythematosus (SLE), treatment of inflammatory joint disease, application prospects of targeted drugs and biological agents were shared .
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The Qi Hai team of Tsinghua University found that virtual memory T cells coordinate extralymphatic responses that are conducive to resident memory
Time of Update: 2021-10-02
In this study, it was found that TVM cells are heterogeneous in terms of effect and memory potential, and these cells can quickly infiltrate the site of infection, directly coordinating the primary response of TRM cells in the tissue .
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Is allopurinol an advantage in treating gout?
Time of Update: 2021-10-02
⑤ Wang Xiaoliu and others reported 2 deaths in "Clinical Analysis of 13 Cases of Severe Drug Eruption Caused by Allopurinol" .
⑥ Fan Jiaojiao and others reported a death case in "Clinical Analysis of 50 Cases of Severe Drug Eruption in Elderly Hospitalized Patients" .
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Zhu Huifang and others from Gannan Medical College published a review of the latest research progress of PARPs in innate immunity
Time of Update: 2021-10-02
08): When PARPs Meet Antiviral Innate Immunity, a systematic review of the latest research progress in related fields, and a summary of the role of PARPs in regulating the body’s antiviral The role of virus in natural immunity and its molecular mechanism .
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Zhu Huifang, the First Affiliated Hospital of Gannan Medical College, was invited to publish a review in Trends in Microbiology
Time of Update: 2021-10-02
Zhu Huifang from the First Affiliated Hospital of Gannan Medical College was invited to publish a review in Trends in Microbiology: When PARPs Meet Antiviral Innate Immunity, systematically reviewed the latest research progress in related fields, and summarized the role of PARPs in regulating the body's antiviral natural immunity And its molecular mechanism .
