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Front Immunol: Immunosuppressive therapy modulates to varying degrees the humoral and T cell specific responses of rheumatoid arthritis patients to the COVID-19 mRNA vaccine.
Time of Update: 2021-10-19
To evaluate the SARA-COV -2 specific immune response induced by anti-regional binding domain (RBD) antibodies and T cell specific immune responses in patients with rheumatoid arthritis (RA) treated with different immunosuppressive therapies, and the vaccine Safety of clinical effects of disease activity .
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What is the effect of biological agents in the treatment of Sjogren's syndrome? How to choose?
Time of Update: 2021-10-19
In an open trial involving 30 patients with primary Sjogren’s syndrome, it was found that belimumab treatment for 28 weeks can reduce the disease activity index of Sjogren’s syndrome and improve the parotid gland enlargement, arthritis/arthralgia, and blood The level of immunoglobulin and rheumatoid factor .
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Arthritis Rheumatol: Is it helpful to start using biologics early in polyarticular juvenile idiopathic arthritis?
Time of Update: 2021-10-19
Methods: The investigators analyzed polyarticular JIA patients (n = 400) participating in the Polyarticular JIA Start Time Optimization Study (STOP-JIA ) and a comparative cohort from the Children’s Arthritis and Rheumatism Research Alliance Registry (n = 248) ) Data .
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The weather vane of rheumatic immune disease-there are so many ways for biomarkers...
Time of Update: 2021-10-11
With continuous in-depth research, people have discovered that there is a real possibility of "seeking common ground": A study pointed out that type I interferon (IFN) pathways exist in 5 rheumatic immune diseases including SLE, RA, SSc, etc.
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Smoking, environment, occupation!
Time of Update: 2021-10-11
120899[5]Yahya A,Bengtsson C,Larsson P,et al(2014)Silica exposure is associated with an increased risk of developing ACPA-positive rheumatoid arthritis in an Asian population:evidence from the Malaysian MyEIRA case-control study.
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Two mechanisms by which PNAS bacterial RLs activate plant immunity
Time of Update: 2021-10-11
The Non-self-recognition Invasion Pattern from pathogenic bacteria recognizes and stimulates each other through pattern recognition receptors (PRRs) such as receptor kinases (RKs) or receptor-like proteins (RLPs) on the plasma membrane of the host plant The initiation and transmission of immune signals [1-3] .
The research paper revealed the mechanism of bacterial rhamnolipid activating plant immunity through two different ways .
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Oral complement C5a receptor inhibitor approved in Japan
Time of Update: 2021-10-11
Retrieved September 27, 2021, from https:// en/[2] ChemoCentryx Announces Approval in Japan of Tavneos™ (Avacopan) for the Treatment of ANCA-Associated Vasculitis.
Retrieved September 27, 2021, from https:// 27/2303617/19219/en/ChemoCentryx-Announces-Approval-in-Japan-of-Tavneos-Avacopan-for-the-Treatment-of-ANCA-Associated-Vasculitis.
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What should I do with chronic kidney disease combined with acute gout attacks?
Time of Update: 2021-10-11
In addition, for patients with contraindications to non-steroidal anti-inflammatory drugs, including CKD, heart failure or hypertension, the use of glucocorticoids is a good intervention .
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The disease relapses as soon as the hormone is reduced. This rheumatism patient is too difficult!
Time of Update: 2021-10-11
Combined with the physical examination at the time, the patient had extensive skin rash, symmetrical proximal limb weakness, elevated serum muscle enzymes, electromyogram indicating muscle damage, positive anti-TIF1-γ antibody, etc.
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If the antibody is positive and there are symptoms, it must be lupus that "meets the diagnostic criteria"?
Time of Update: 2021-10-11
Professor Karp introduced that there are only a small number of people at high risk of systemic lupus erythematosus (SLE) in the world, and related risk factors include genetics, sun exposure, metabolic abnormalities, and diet .
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Ankylosing spondylitis and axial psoriatic arthritis are stupidly confused?
Time of Update: 2021-10-11
In order to determine the consistency between the IBP judged by rheumatologists in PsA patients and the criteria for defining IBP, and the predictive value of IBP in identifying the central axis of PsA, a standard for PsA IBP A prospective study of the prevalence, characteristics, and clinical manifestations of the disease used the kappa coefficient to investigate the consistency between rheumatologists’ judgments of IBP and IBP criteria (assessed by Calin, Rudwaleit, and the International Spondyl Arthritis Association) .
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NEJM: Ozanimod as an induction and maintenance treatment for ulcerative colitis
Time of Update: 2021-10-10
InfectIt can be seen that Ozanimod is more effective than placebo as an induction and maintenance treatment for patients with moderate to severe active ulcerative colitis .
Ozanimod is more effective than placebo as an induction and maintenance treatment for patients with moderate to severe active ulcerative colitis .
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More suitable for Asian crowd!
Time of Update: 2021-10-10
The preparation of the management guidelines is guided by clinical issues, based on evidence-based medicine, in line with international concepts, combined with the characteristics of SLE patients in the Asia-Pacific region, and provides rheumatology immunologists with standardized diagnosis and treatment of SLE in terms of diagnosis, disease evaluation and treatment.
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PNAS bacterial rhamnolipid and its precursor 3-hydroxyalkanoate activate Arabidopsis innate immunity through two independent mechanisms
Time of Update: 2021-10-10
First, the author detected the production of apoptotic reactive oxygen species triggered by RLsec (a mixture of RL homologues and HAA precursors released by Pseudomonas) in Arabidopsis and whether RLsec induces the semi-biological vegetative plant pathogen syringa The local resistance of Pseudomonas proves that RLsec induces immune-related signals and disease resistance in Arabidopsis thaliana, partly mediated by the lectin RK LORE .
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Strictly taboo, why does uric acid rise instead of falling?
Time of Update: 2021-10-10
The level of uric acid in the blood is above the saturation point for a long time, which will cause uric acid to form crystals and deposit in the peripheral joints of the feet, knees, hands and elbows, especially the joints affected by osteoarthritis .
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The "commonly used medicine" of rheumatism patients can actually cause this kind of shock!
Time of Update: 2021-10-10
Although diclofenac sodium suppository is a commonly used clinical fever and analgesic, and rectal administration is effective It avoids common gastrointestinal adverse reactions, but the drug can also cause shock.
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Super antigen induces regulatory T cells to make progress
Time of Update: 2021-10-10
The phenotypic characteristics and induction mechanism of CD4+ Tregs induced by super antigen Source: Shenyang Institute of Applied Ecology, Chinese Academy of Sciences
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ARD: Temporary discontinuation of mycophenolate mofetil in patients with rheumatism and musculoskeletal diseases enhances the humoral response to SARS-CoV-2 vaccination
Time of Update: 2021-10-10
Preliminary results show that it is safe to stop mycophenolate mofetil before and after SARS-CoV-2 vaccination in patients with rheumatism and musculoskeletal diseases , and can enhance antibody response .
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Rheumatology: New Ideas for Ultrasonic Diagnosis of Pulmonary Hypertension Related to Systemic Sclerosis
Time of Update: 2021-10-10
It compares the positive predictive value (PPV) between the echocardiographic-derived tricuspid annulus plane systolic deviation/systolic pulmonary artery pressure (TAPSE/sPAP) ratio and the DETECT algorithm in a group of SSc patients for PAH screening Check .
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JEADV: Study on the movement of nail belts in patients with systemic lupus erythematosus
Time of Update: 2021-10-10
This article reports on a patient with systemic lupus erythematosus (SLE), the change process of red half-moon nails during the course of the disease .
At the time of examination, except for the left hand nail, there are half-moon-shaped red-violet bands around the distal edge of the crescent (Figure 1A and 1B) .
