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Front Immunol: Targeting FcRN: A New Way to Treat Pemphigus
Time of Update: 2021-10-20
Competitive inhibition of FcRN-IgG binding by FcRN inhibitors (RED) leads to decreased IgG circulation, increased IgG degradation in lysosomes, decreased circulating anti-DSG1 and anti-DSG3IgG autoantibodies, and decreased pemphigus disease activity .
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ARD: Genome sequencing and functional analysis to identify MAP4K3/GLK germline and somatic mutations associated with systemic lupus erythematosus
Time of Update: 2021-10-20
in conclusion:Conclusion: Conclusion:Multiple GLK germline and somatic mutations in SLE patients induce GLK overexpression by increasing mRNA or protein stability .
Multiple GLK germline and somatic mutations in SLE patients induce GLK overexpression by increasing mRNA or protein stability .
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Do not do things that damage joints on World Health Day!
Time of Update: 2021-10-20
When climbing stairs or mountains, in addition to increasing the weight bearing of the knees, the knees must also move back and forth and twist sideways, which will cause wear and tear on the soft tissues of the meniscus and other joints.
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Systematic review and meta-analysis: TCM decoction can treat Behcet's disease
Time of Update: 2021-10-19
got the answer:Meta-analysis showed that compared with the control group, the total effective rate and cure rate of traditional Chinese medicine decoction were significantly higher, and the recurrence rate was significantly reduced .
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How effective are biological agents in treating Sjogren’s syndrome? How to choose?
Time of Update: 2021-10-19
In an open trial involving 30 patients with primary Sjogren’s syndrome, it was found that belimumab treatment for 28 weeks can reduce the disease activity index of Sjogren’s syndrome and improve the parotid gland enlargement, arthritis/arthralgia, and blood Immunoglobulin and rheumatoid factor levels .
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Acta Derm Venereol: transplantation of non-cultured autologous epidermal cells suspended in hyaluronic acid can effectively and safely treat vitiligo and alopecia areata
Time of Update: 2021-10-19
Recently, a randomized study published in Acta Derm Venereol evaluated non-cultured autologous epidermal cell transplantation resuspended in hyaluronic acid vs.
, Assessment of Non-cultured Autologous Epidermal Cell Grafting Resuspended in Hyaluronic Acid for Repigmenting Vitiligo and Piebaldism Lesions: A Randomized Clinical Trial.
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J PHYSIOTHER: Patient education can improve the pain and dysfunction of patients with osteoarthritis, combined with exercise therapy for better results
Time of Update: 2021-10-19
For patients with knee osteoarthritis, patient education as an independent intervention factor or combined with other intervention factors for treatment Will there be a better effect?This study conducted a systematic review of patients with knee osteoarthritis, with the main purpose of evaluating the impact of patient education on self-reported pain and functional outcomes of patients with osteoarthritis .
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Mult Scler: The seroconversion rate of patients with relapsing-remitting multiple sclerosis is reduced after the application of a single SARS-COV-2 vaccine
Time of Update: 2021-10-19
To determine whether they produce a humoral immune response, we tested the SARS-COV-2IgG seroconversion rate after vaccination .
Conclusion: Our goal is to determine whether patients treated with the B-cell depleting drug ocrelizumab developed a detectable humoral immune response after being vaccinated with the SARSCOV-2 vaccine .
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Fried chicken with cola, let gout target the 25-year-old guy
Time of Update: 2021-10-19
Analysis and processingAnalysis and processingThe patient’s unhealthy diet led to excessive intake of fructose and purines, increased uric acid production, and urate deposition in various joints, leading to gouty arthritis.
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NPJM: Metagenome analysis reveals the potential role of gut microbiota in the pathogenesis of gout
Time of Update: 2021-10-19
Therefore, there is a lack of comprehensive understanding of how and which key pathophysiological processes of gut microbes may affect gout (such as host uric acid degradation and systemic inflammation), and further studies are needed in further longitudinal studies to describe the clinical parameters of patients in detail .
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Arthritis Rheumatol: Is body fat content related to the risk of rheumatoid arthritis?
Time of Update: 2021-10-19
In a summary of data from the genome-wide association study ( GWAS ) of approximately 500,000 people in the UK Biobank , bioelectrical impedance is used to measure body fat mass, body fat-free mass (muscles and internal organs), body fat percentage and limbs Lean body mass (mainly skeletal muscle) .
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Eur Respir J: Influence of patient baseline characteristics on the efficacy of dupilumab in the treatment of type 2 hyperphenotypic asthma
Time of Update: 2021-10-19
Whether the efficacy of Eur Respir J dupilumab in the treatment of type 2 hyperphenotypic asthma (blood eosinophils ⩾150 cells/µL or FeNO⩾20 ppb) is affected by the patient’s baseline characteristics (sex, region, body mass index, age, age at asthma attack, The effects of drug use, FEV1 before bronchodilator use, the number of acute exacerbations of asthma in the previous year, smoking history, blood eosinophil level, FeNO)544 patients received placebo and 1040 patients received dupilumab .
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It cannot be ignored, "dryness" is also a disease!
Time of Update: 2021-10-19
Although primary Sjogren’s syndrome is a not uncommon disease, because some patients, especially young women, have no obvious symptoms in the early stages of the disease, the time from onset to diagnosis is often as short as a few months, and the length can reach It was diagnosed after more than 10 years and often had obvious visceral damage, such as renal tubular acidosis and pulmonary interstitial fibrosis, and lost the best time for treatment.
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A&R: Transcriptomics evaluation of adolescent skin with local scleroderma with histological and clinical relevance
Time of Update: 2021-10-19
Assess the correlation of differentially expressed genes ( DEGs ) with the histopathological and clinical characteristics of adolescent LS children, and group the children into different genetic clusters based on the immunophenotype .
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Targeting IL-4R monoclonal antibody (AK120) to treat atopic dermatitis and asthma, China Phase II clinical trial has been launched
Time of Update: 2021-10-19
Akeso pharmaceutical company announced that its drug candidate anti-IL-4R monoclonal antibody (AK120) has received Chinese State Drug Administration approved the Board Center for Drug Evaluation (CDE) of, II clinical trials for the treatment of moderate to severe asthma to launch in China .
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Rheumatology: 1 case of systemic lupus erythematosus complicated with retinal vascular occlusion in both eyes
Time of Update: 2021-10-19
(B) The fundus of the left eye shows disc-shaped hyperemia, a pale and edematous retina with a clear boundary above the retina, and a sheath-like area around blood vessels .
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Arthritis Rheumatol: Is it helpful to start using biologics early in polyarticular juvenile idiopathic arthritis?
Time of Update: 2021-10-19
Methods: The investigators analyzed polyarticular JIA patients (n = 400) participating in the Polyarticular JIA Start Time Optimization Study (STOP-JIA ) and a comparative cohort from the Children’s Arthritis and Rheumatism Research Alliance Registry (n = 248) ) Data .
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J PHYSIOTHER: What is the treatment experience provided by physiotherapists for patients with knee osteoarthritis? Does it meet national standards?
Time of Update: 2021-10-19
By increasing attention to the psychosocial aspects of nursing, and more proactively providing recommendations and/or referrals on weight loss, painkillers, and knee surgery, nursing outcomes can be further improved, and common osteoarthritis medications and surgical interventions are described The potential benefits and harms of physical therapists can also ensure that their patients fully understand all their treatment options .
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Ann Rheum Dis: Comparison of the occurrence of severe infections in patients with rheumatoid arthritis and psoriatic arthritis treated with tumor necrosis factor inhibitors
Time of Update: 2021-10-19
Recently, Annals of the Rheumatic Diseases, a top journal in the field of rheumatism, published a research article, researchers aiming to evaluate rheumatoid arthritis (RA) and psoriatic arthritis treated with tumor necrosis factor inhibitor (TNFi) (PsA) the incidence of severe infection (SI) in patients, and compare the risk of severe infection (SI) in RA patients and PsA patients .
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NEJM: Efficacy and safety of Bimekizumab VS. Secukinumab in the treatment of plaque psoriasis
Time of Update: 2021-10-19
Compared with secukinumab in patients with moderate to severe plaque psoriasis, the efficacy and safety of bimekizumab have not been extensively studied .
