-
If a patient with hepatitis B encounters arthritis, the diagnosis can be confirmed by observing this symptom!
Time of Update: 2021-10-22
HBV-associated arthritis vs RA combined with HBV infection: joint symptoms are the key As of 2019, there are 296 million patients with hepatitis B virus (HBV) infection worldwide, of which 1.
-
Express Janssen IL-12/IL-23 inhibitor submits a new application to the FDA for the treatment of children with psoriatic arthritis
Time of Update: 2021-10-22
▎Editor of WuXi AppTec Content Team Recently, Janssen, a subsidiary of Johnson & Johnson, announced that it has submitted its IL-12/IL-23 inhibitor Stelara (ustekinumab) supplementary biological product license application to the US FDA ( sBLA), used to treat children with juvenile psoriatic arthritis (jPsA) over 5 years old .
-
Long-term use of "hormones", it is recommended to be less than this dose every day!
Time of Update: 2021-10-22
The results of the Dutch multi-center CAMERAII study showed that [2] adding low-dose prednisone to the treatment strategy based on methotrexate (MTX) to strictly control early RA can improve the prognosis of patients .
-
Can gout patients take the medicine twice a month, can the uric acid be lowered?
Time of Update: 2021-10-22
According to the "Research Progress of Biological Agents in the Treatment of Refractory Gout" (2020), the use of Pegloticase can easily induce acute attacks of gout and infusion-related reactions (IRs), and may worsen existing cardiovascular diseases.
-
Express U.S. FDA approves the first oral complement 5a receptor inhibitor
Time of Update: 2021-10-22
▎Editor of WuXi AppTec's content team On October 8, 2021, ChemoCentryx announced that the US FDA has approved the oral selective complement 5a (C5a) receptor inhibitor Tavneos (avacopan) to be marketed, combined with standard therapies, and two main adjuvant treatments Anti-neutrophil cytoplasmic autoantibodies (ANCA) related vasculitis: microscopic polyangiitis (MPA) and granuloma with polyangiitis (GPA) .
-
Fever + skin rash + swollen lymph nodes, it is this kind of acute and critical illness!
Time of Update: 2021-10-22
Differentiation from KD: Although MAS may occur in patients with KD, as the disease progresses, clinicians should consider that the underlying diagnosis may actually be SoJIA .
SoJIA, which is manifested as MAS, is a common clinical symptom, a rare disease with a high mortality rate.
-
Express U.S. FDA approves the first thymic tissue regeneration therapy
Time of Update: 2021-10-22
▎The content team editor of WuXi AppTec today, the US FDA announced that it has approved the marketing of Rethymic, a thymus tissue therapy, for the treatment of congenital athymia in children, which is a rare immune disease .
-
The bone mass "emptied" by rheumatism, experts will bring you back
Time of Update: 2021-10-21
——Experts will take you to recover the bone health that has slipped away.
The copyright of this article belongs to the original author.
This article is only used to provide scientific information to medical and health professionals, and does not represent the platform's position .
-
Because of this rheumatism, I almost cut off my testicles!
Time of Update: 2021-10-21
The positive staining rate of IgG4 in some areas is as high as 50%, confirming the diagnosis of IgG4-related paratesticular fibrous pseudotumor (Figure 3) .
Most patients have painless scrotal masses for several years, but because half of the cases are related to hydrocele, other symptoms may occur .
-
Immunity Tsinghua University's Dong Chen team discovered a new regulatory mechanism for T follicular helper cell development
Time of Update: 2021-10-21
The expression of transcription factor Zfp831 is inhibited by ERK, which promotes Tfh cell differentiation by directly up-regulating the expression of transcription factors Bcl6 and Tcf7 .
Therefore, this study determined that the ERK-Zfp831 axis, which is regulated by costimulatory signals, plays a key regulatory role in Tfh cell development .
-
Suffering from ankylosing spondylitis for decades, this "pain reliever" was always available at home, and the kidney broke down in the end...
Time of Update: 2021-10-21
1 week before admission, patients with a history of present illness have no obvious causes of nausea, vomiting, dizziness, mild swelling of the lower limbs, no headache, no fear of cold, fever, chest tightness, no shortness of breath, no oliguria, foamy urine, no rash, or photosensitivity , No oral ulcers, joint swelling and pain, no abdominal pain and diarrhea and other discomforts, go to the local hospital, check creatinine: 288μmol/L, glomerular filtration rate (GFR): 18.
-
[The BMJ] Are you still worried that Pfizer will have very little antibodies after 6 months of vaccination, but its protective effect against serious diseases still exists!
Time of Update: 2021-10-21
Author: Daisy Guide: Recently, two articles published in New England Journal of Medicine showed that-six months after the second dose of BNT162b2 vaccine, the antibody concentration was significant Decrease, especially in men, people 65 years of age or older, and immunosuppressed people .
-
Immunity Zheng Jie's team reveals K63-polyUb-mediated MDA5-MAVS antiviral signaling pathway assembly program and activation mechanism
Time of Update: 2021-10-21
On October 12, 2021, Zheng Jie’s team from the Shanghai Institute of Materia Medica, Chinese Academy of Sciences published the Ordered assembly of the cytosolic RNA-sensing MDA5-MAVS signaling complex via binding to unanchored K63-linked poly-ubiquitin online in Immunity as a Research Article chains, revealing the molecular mechanism by which long chains rather than anchoring K63-polyUb promote MDA5-MAVS assembly procedures and signal transmission .
-
What are the six classic signs of common rheumatism?
Time of Update: 2021-10-21
Therefore, in clinical practice, many doctors always have headaches in their diagnosis, but some patients with very typical signs are not helpful in diagnosing the disease.
-
The Shen Xihui team of Northwest A&F University and others published a paper on PNAS, revealing the important role of manganese ions in anti-bacterial natural immunity
Time of Update: 2021-10-21
On October 9, 2021, the Jiang Zhengfan Laboratory of the Beijing University of Science and Technology, the Shen Xihui Laboratory of Northwest A&F University and the Zhou Dongsheng Laboratory of the Military Medical College jointly published an online publication titled T6SS in the Proceedings of the National Academy of Sciences (PNAS) The research paper translocates a micropeptide to suppress STING-mediated innate immunity by sequestering manganese has achieved a new breakthrough in the field of anti-bacterial innate immunity .
-
[Nature] How does the immune system maintain the balance of intestinal flora?
Time of Update: 2021-10-21
Tim Rollenske and Professor Andrew Macpherson of the Department of Biomedical Research (DBMR) of the University of Berne was recently able to prove in a mouse model that IgA antibodies can specifically limit benignity at the Hospital of Internal Surgery and Medicine of the University of Bern.
-
Front Immunol: Research on Anti-desmosome Collagen Autoantibodies in Autoimmune Blister Disease
Time of Update: 2021-10-20
The presence of anti-DSC antibodies should be considered under different circumstances: the clinical features of PH, PVEG or atypical pemphigus; the presence of pustules; patients with classic pemphigus without anti-DSG antibodies; histological examination of intraepithelial neutrality Granulocyte/eosinophil or dermal neutrophil/eosinophil infiltration, and dual-mode DIF examination .
-
Immunity Dong Chen's team discovers a new mechanism for follicular helper T cell regulation
Time of Update: 2021-10-20
On October 12, 2021, the team of Professor Dong Chen from the Institute of Immunology of Tsinghua University published an online research paper entitled Costimulation molecules differentially regulate the ERK-Zfp831 axis to shape T follicular helper cell differentiation in Immunity.
-
Arthritis & Rheumatology: Genetic and epigenetic fine-tuning of TGFB1 expression in human osteoarthritis joints
Time of Update: 2021-10-20
OA risk SNP rs75621460 affects TGFB1 expression by regulating enhancer function Original source:Original source:Rice SJ, Roberts JB, Tselepi M, Brumwell A, Falk J, Steven C, Loughlin J.
-
CRAL: Comparison of treatment guidelines for pemphigus: systemic glucocorticoids, rituximab and other immunosuppressive therapies
Time of Update: 2021-10-20
In mild pemphigus, shock therapy is usually not preferred over daily oral corticosteroids, but refractory types should be considered and introduced as a second-line option, only recommended by ASMSG .
