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Arthritis Rheumatol: Pregnancy outcomes in women with psoriatic arthritis are related to anti-rheumatic treatment and timing
Time of Update: 2021-11-01
It can be seen that compared with non-PsA pregnancy, the risk of premature delivery and cesarean section is mostly increased in people who receive anti-rheumatic treatment (especially biologics) during pregnancy .
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The imbalance of tissue homeostasis in SpA is closely related to the abnormal regulation of this cytokine
Time of Update: 2021-10-23
Under normal bone homeostasis, the inflammatory immune response at the injury site of the attachment point can drive tissue repair, but under pathological conditions, excessive activation of the immune system causes chronic inflammation and new bone formation, that is, excessive bone repair response, leading to the characteristic of AS disease The appearance of phenotype [5] .
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What is the research progress of "early rheumatoid arthritis"?
Time of Update: 2021-10-23
Figure 2: MRI and US sensitivity and specificity comparison [3] Figure 3: US and MRI joint and tendon counts used to identify the diagnostic performance of the receiver operating curve of RA [3] the new ERA standard in the rheumatoid population Preliminary verification This is a classification standard study for ERA, the research object is early (symptom duration <1 year) IA patients .
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PNAS│Academician Cao Xuetao's team discovers a new mechanism for non-coding RNA to regulate inflammation in lung tissue
Time of Update: 2021-10-22
On October 5, 2021, the team of Academician Cao Xuetao (Zhejiang University is the first unit) published a research paper entitled "Cis-acting lnc-Cxcl2 restrains neutrophil-mediated lung inflammation by inhibiting epithelial cell CXCL2 expression in virus infection" in PNAS online The non-coding RNA-lnc-Cxcl2 found in this study inhibits the expression of Cxcl2 in lung epithelial cells during the viral infection process, inhibits neutrophil-mediated lung tissue inflammation, in order to control lung tissue inflammatory damage and increase viral infections, etc.
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[Nature Sub-Journal] Lung epithelial cells control lung immunity?
Time of Update: 2021-10-22
"This has led to the discovery that the molecular target of these cancer treatments is one of the molecules that rely on MHC-II to reach the cell surface, and that the harmful side effects of checkpoint inhibitor therapy may be the result of lung epithelial cells instructing and suppressing immune cells .
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Regarding treatment options for RA biologics, what do these real-world studies show?
Time of Update: 2021-10-22
The post-hoc analysis of the CERTAIN prospective cohort study showed that if the patient had a high level of anti-CCP2 antibody at baseline, after 6 months of treatment with abatacept, the CDAI score (Clinical Disease Activity Index) had a greater numerical change, and the patient Reported outcomes (PROs) improved more significantly (Figure 3) [5] .
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PNAS Shen Xihui/Jiang Zhengfan/Zhou Dongsheng collaborated to reveal that the bacterial type VI secretion system chelates manganese ions to inhibit the host's natural immune response
Time of Update: 2021-10-22
Correspondingly, c-di-GMP can be recognized by STING of host cells and activate STING, triggering anti-bacterial natural immune response; and manganese ions can significantly promote their binding to STING [3, 6, 7] .
. TssS chelates manganese ions to inhibit STING-mediated antibacterial innate immune response in host cells.
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Patients with RA have been using "hormones" for a long time, and it is recommended to use less than this dose every day!
Time of Update: 2021-10-22
The results of the Dutch multi-center CAMERAII study showed that [2] adding low-dose prednisone to the treatment strategy based on methotrexate (MTX) to strictly control early RA can improve the prognosis of patients .
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Immunity revised textbook!
Time of Update: 2021-10-22
On October 8, 2021, the joint communication between Heping Xu and Danyang He of West Lake University published a research paper entitled "Early developing B cells undergo negative selection by central nervous system-specific antigens in the meninges" in Immunity.
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Taifeier Biopharmaceuticals announces the enrollment of the first patient of X0002, and the Phase III clinical trial is in full swing in the United States
Time of Update: 2021-10-22
Phase II clinical studies in the United States and China show that X0002 is significantly better than clinical drugs in improving WOMAC pain, improving arthritis disease status and safety in patients with osteoarthritis, and has the potential to treat osteoarthritis .
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PNAS: Shen Xihui's team from Northwest A&F University and others reveal the important role of manganese ions in anti-bacterial natural immunity
Time of Update: 2021-10-22
On October 9, 2021, the Jiang Zhengfan Laboratory of the Beijing University of Science and Technology, the Shen Xihui Laboratory of Northwest A&F University and the Zhou Dongsheng Laboratory of the Military Medical College jointly published an online publication titled T6SS in the Proceedings of the National Academy of Sciences (PNAS) The research paper translocates a micropeptide to suppress STING-mediated innate immunity by sequestering manganese has achieved a new breakthrough in the field of anti-bacterial innate immunity .
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If a patient with hepatitis B encounters arthritis, the diagnosis can be confirmed by observing this symptom!
Time of Update: 2021-10-22
HBV-associated arthritis vs RA combined with HBV infection: joint symptoms are the key As of 2019, there are 296 million patients with hepatitis B virus (HBV) infection worldwide, of which 1.
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The lungs have a strong "immune memory" for the new crown infection, new research suggests that the vaccine response may exceed expectations
Time of Update: 2021-10-22
▲The new coronavirus-specific immune cells were detected in the tissues of four organ donors who had previously been infected with the new crown (picture source: reference [1]).
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Immunity Xu Heping/He Danyang team discovered that B lymphocytes develop in the meninges and undergo negative screening mediated by specific antigens of the central nervous system
Time of Update: 2021-10-22
On October 8, 2021, the Xu Heping research group of West Lake University and He Danyang's research group jointly published a research paper entitled Early developing B cells undergo negative selection by central nervous system-specific antigens in the meninges in Immunity magazine .
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Express delivery of more than half of the symptoms of vitiligo patients improved by 50%, and topical JAK inhibitors announced the complete phase 3 clinical results
Time of Update: 2021-10-22
▎The content team editor of WuXi AppTec recently, Incyte announced the complete results of a pivotal Phase 3 clinical trial of its topical JAK inhibitor ruxolitinib cream (ruxolitinib, English trade name Opzelura) in the treatment of patients with vitiligo over 12 years old .
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A large longitudinal study shows that the cross-protective antibodies of dengue fever and Zika virus last longer than expected｜《Science·Translational Medicine》
Time of Update: 2021-10-22
Click on the blue text above to follow our new 11-year longitudinal study of more than 4,000 Nicaraguan children.
It unexpectedly showed that antibodies produced by dengue fever and Zika virus infection can prevent these two viruses and maintain Stable for many years, rather than declining rapidly as previously thought .
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Why does the new crown vaccine have poor protection for some people?
Time of Update: 2021-10-22
The author also talked about the future goal is to directly monitor a variety of serum immunoglobulins and sequencing based on mass spectrometry when they appear in the circulation and play a role in the human immune response .
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Interpretation of multi-faceted guidelines, how to accurately apply hormones in the treatment of lupus nephritis?
Time of Update: 2021-10-22
In the maintenance treatment stage, the hormone should be gradually reduced to the lowest effective dose to maintain the disease without recurrence.
In the remission induction treatment stage, high-dose hormones or even methylprednisolone shock therapy are required.
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Immune-mediated treatment of inflammatory diseases: past, present and future
Time of Update: 2021-10-22
In the 1990s, TNF and IL-1 pathways had similar characteristics of perceived immune function (both cytokines are present in disease tissues, and it seems feasible to be targets in in vivo disease models), TNF inhibitors (instead of IL-1 inhibitor) has achieved important success in the clinical application of RA .
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Where is the "god" effect of the hypoglycemic drug metformin on rheumatism?
Time of Update: 2021-10-22
1. Rheumatoid arthritis (RA): Metformin can affect the neutrophil extracellular bactericidal network (NETs), M2 type macrophages, The expression of rheumatoid factor (RF) subgroups can simultaneously play a role in bone protection and regulate the effects of intestinal microbes to achieve RA remission, which may open up a new clinical treatment perspective for RA; and has the advantages of fewer adverse reactions and low cost, which is expected Become one of the more ideal treatment drugs for RA .
