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Shingles vaccine, 11 questions you care about are here!
Time of Update: 2022-01-21
How to avoid getting these diseases?In fact, for patients, prevention is better than cure, and vaccinating against herpes zoster as soon as possible is the most effective means .
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ARD: clusters of trajectories of radiographic progression in patients with rheumatoid arthritis: associations with clinical variables
Time of Update: 2022-01-21
The investigators identified four distinct clusters with characteristic radiographic progression shapes: one with stable SHS throughout the 2 -year period ( C0/lowChange ; 86% ); one with persistent progression ( C1/ rising; 5.
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ARD: Attacks following hydroxychloroquine reduction or discontinuation: results from the Systemic Lupus International Collaborating Clinic (SLICC) initial cohort
Time of Update: 2022-01-21
The aim of this study was to assess the severity of systemic lupus erythematosus (SLE) episodes with hydroxychloroquine (HCQ) reduction or discontinuation versus HCQ maintenance .
Researchers are still at each HCQ Separate multivariate risk regressions were performed in the subcohorts to identify factors associated with SLE episodes .
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For the treatment of rheumatoid arthritis, a large inventory of 5 types of guideline-recommended drugs
Time of Update: 2022-01-21
Glucocorticoids, such as prednisone, have immune-modulating and anti-inflammatory properties, reduce inflammation and pain, and slow joint damage .
Prednisone, which has immune modulating and anti-inflammatory properties, reduces inflammation and pain, and slows joint damage Osteoporosis Osteoporosis 4.
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inventory!
Time of Update: 2022-01-10
In order to better address the needs of patients with refractory RA, the European Union Against Rheumatism (EULAR) issued the first "Guiding Recommendations for D2T-RA Treatment" on August 18 .
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Rheumatism patients want to prepare for pregnancy, pregnancy, these 6 drugs must be stopped!
Time of Update: 2022-01-10
The use of peri-pregnancy drugs must take into account the two aspects of maintaining the mother's condition and ensuring the safety of the fetus, and adjust the treatment plan in time .
The drugs that male rheumatism patients can continue to use during the fertility preparation period include azathioprine, colchicine, hydroxychloroquine and various TNF inhibitors .
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"8 Gout Diagnosis and Treatment Scenarios + 22 Recommendations", "APLAR Gout Treatment Clinical Practice Guidelines (2021 Edition)" released!
Time of Update: 2022-01-10
(Quality of Evidence: Low) Scenario 3: Starting ULT, how to prevent gout attacks?
➤Guide recommendations: When starting ULT treatment, it is recommended to use low-dose colchicine to prevent gout attacks .
(Weak recommendation, quality of evidence: very low) Scenario 5: Treatment of chronic gout (CTG) 11.
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Nat Immunol Ye Lilin/Xu Jianqing/Yin Zhinan et al. Reveal a new mechanism for virus-specific CD4+ T cell immune memory maintenance
Time of Update: 2022-01-10
On December 23, 2021, the team of Professor Ye Lilin from the Army Military Medical University published a research paper entitled The kinase complex mTORC2 promotes the longevity of virus-specific memory CD4+ T cells by preventing ferroptosis in Nature Immunology, which reported the passage of mTORC2 signal.
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Express significantly reduces the risk of disease onset, IL-17A inhibitors are approved for Category 5 indications
Time of Update: 2022-01-10
▎Editor of WuXi AppTec's content team recently, Novartis announced that the US FDA has approved Cosentyx (secukinumab) for the treatment of active attachment-related arthritis (ERA) 4 years old and older, and activities for patients 2 years and older Juvenile Psoriatic Arthritis (JPsA) .
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Moderna's new paper: mRNA encoding monoclonal antibody against Chikungunya virus
Time of Update: 2022-01-10
As early as May 2019 before the outbreak of the new crown epidemic, Moderna had published a pre-clinical research paper in Science Immunology [2], using lipid nanoparticles (LNP) to deliver the light chain of the encoding human monoclonal antibody (CHKV-24 IgG) And heavy chain mRNA, targeting the E2 glycoprotein of Chikungunya virus, can protect mice infected with Chikungunya virus from arthritis, musculoskeletal diseases and fatal attacks.
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Nature's Five Bursts: Assessing the Escape of Omi Keron Mutants to Vaccines and Antibodies
Time of Update: 2022-01-10
Link to the paper: https:// The neutralizing effect of the new crown virus Omi Keron variant has a large escape from the neutralization of antibodies, Olivier Schwartz of the Pasteur Institute in France and colleagues from Belgium An individual in, isolated an Ome Keron virus and analyzed how sensitive the virus is to 9 monoclonal antibodies that are currently approved for clinical use or are still in development .
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Studies have discovered the immunogenic mechanism of in vitro synthesis of circular RNA and its potential applications
Time of Update: 2022-01-10
By comparing the characteristics of different methods of in vitro synthesis of circular RNA, this study clarified the immunogenicity of in vitro synthesis of circular RNA and the molecular mechanism, and found that circular RNA with no immunogenicity and double-stranded structure can effectively inhibit natural immune factors The activation of PKR reveals the application potential of in vitro synthesized circular RNA for the treatment of autoimmune diseases related to abnormal activation of PKR .
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Chen Lingling's team: The immunogenicity and potential applications of in vitro synthesized circular RNA, a conversation scientist at Cell Press
Time of Update: 2022-01-10
The previous work of Chen Lingling's research group found that endogenous circular RNA containing 16-26bp double-stranded structure can inhibit the abnormal activation of immune factor PKR (Liu, Cell 2019), suggesting that in vitro synthesis of non-immunogenic circular RNA containing short double-stranded structure is expected Become a new method to treat autoimmune diseases related to excessive activation of PKR .
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What happened to those who had high uric acid and dared to eat and drink casually?
Time of Update: 2022-01-09
(For specific medical nutrition treatment, please click on the blue word: Eat like this if you stay away from gout) It is recommended that all patients with hyperuricemia and gout should understand the possible harms of this disease and always control their blood uric acid levels within the ideal range.
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Eight-year follow-up of more than one million women: oral contraceptives and hormone replacement therapy need to be cautious!
Time of Update: 2022-01-09
1), compared with subjects without gout, subjects diagnosed with gout have late menarche, early menopause, shorter reproductive period, use of OC, HRT, and breastfeeding ≥1 The proportion of the year is higher .
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EMBO Rep Deng Cheng’s team discovered that the functional mechanism of large intestine Treg homing originated in amniotic animals
Time of Update: 2022-01-09
Evolutionary analysis and experimental data show that GPR15-C10ORF99 pairing is functionally conserved and mediates the homing of large intestinal Tregs of amniotic animals, and their expression patterns are positively correlated with the diet of herbivores in the large intestine .
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Joint pain, skin rash...These 5 symptoms appear, beware of "psoriatic arthritis"!
Time of Update: 2022-01-09
X-rays of family history of psoriasis suggest osteoporosis▎Axial spondyloarthritis Psoriatic arthritis can also involve the spine in addition to peripheral joint disease of the limbs, which is called axial (spinal) arthritis-type psoriatic joints Inflammation, which accounts for about 5%, is 3-5 times that of female patients in male patients, and it is more common in older patients .
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What should I do if I have an acute attack of gout?
Time of Update: 2022-01-09
According to the "2016 Chinese Gout Diagnosis and Treatment Guidelines", there are three types of drugs to choose from during the acute attack: colchicine, non-steroidal anti-inflammatory drugs, and glucocorticoids .
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The team of Academician Xu Jianguo found that this Lactobacillus plantarum can significantly improve the effect of the new crown vaccine
Time of Update: 2022-01-09
This study shows that oral administration of Lactobacillus plantarum Guanke strain (GUANKE) can enhance the specific immunity against the new coronavirus produced by laboratory mice vaccinated with the new crown vaccine, including neutralizing antibody levels and T cell response indicators.
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Wang Chao of Soochow University/Zhou Xiaozhong of the Second Affiliated Hospital of Suzhou University/Berlin ANBR: Platelet-derived extracellular vesicles target delivery of berberine to reshape the inflammatory environment of rheumatoid arthritis
Time of Update: 2022-01-09
A research paper entitled "Reshaping the Inflammatory Environment in Rheumatoid Arthritis Joints by Targeting Delivery of Berberine with Platelet-Derived Extracellular Vesicles" .
