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One picture to understand the similarities and differences between different "biological agents"
Time of Update: 2022-01-21
How long to stop using biologicsThe use of biological agents generally does not have a course of treatment, but some doctors will give patients a 3-6 month course of treatment because of the cost and risk of side effects, so as to control the acute stage disease into a stable stage, but it does not mean that it will not be stopped after stopping.
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Ann Rheum Dis: Synovial fibroblasts targeting the IL-6-YAP-Snail signaling axis improve osteoarthritis
Time of Update: 2022-01-21
A recent study reported two distinct subpopulations of synovial fibroblasts (SF), immune effector fibroblasts expressing podoplanin (Pdpn) and Thy-1 cell surface antigen (Thy1), in subsynovial tissue Discovers and promotes inflammation, as well as destructive Pdpn+Thy1− fibroblasts in the inner layer, mediating cartilage and bone damage .
Targeting the IL-6-Yap-Snail signalling axis in synovial fibroblasts ameliorates inflammatory arthritis.
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Ann Rheum Dis: Whole enterovirome analysis reveals link between bacteriophages and autoimmune disease
Time of Update: 2022-01-21
RESULTS: Our case-control comparison of viral abundance revealed that in the gut of patients with autoimmune diseases, particularly those with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), as a major component of healthy enteroviruses One of the crAss-like phages was significantly reduced .
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JAMA Intern Med: Association of Immune Dysfunction After SARS-CoV-2 Vaccination with COVID-19 Breakthrough Infection
Time of Update: 2022-01-21
Conclusions and significance: This cohort study found that adequate vaccination was associated with a reduced risk of COVID-19 breakthrough infection, regardless of the patient's immune status .
This cohort study found that adequate vaccination was associated with a reduced risk of COVID-19 breakthrough infection, regardless of the patient's immune status .
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Front Immunol: Protective effects of different biologics on bone loss in rheumatoid arthritis
Time of Update: 2022-01-21
Objective: To compare the changes of bone mineral density (BMD) in patients with rheumatoid arthritis (RA) after taking conventional antirheumatic drugs (CsDMARD), tumor necrosis factor-a inhibitor (TNFi) and abatacept for three years .
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JACI: Parasitic infections may increase the risk of developing airway hyperresponsiveness in children
Time of Update: 2022-01-21
The primary outcome was the incidence of allergic disease, including asthma, wheezing, rhinitis, eczema, and airway hyperresponsiveness (BHR); the secondary outcome was the clinical outcome of respiratory allergic disease, such as exacerbation, hospitalization, symptom severity, and Health-related quality of life .
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Arthritis Rheumatol: Extramucosal formation in rheumatoid arthritis and prognostic value of secreted antibodies
Time of Update: 2022-01-21
Patients with early-stage rheumatoid arthritis who were at high risk for developing arthritis during follow-up (39/82) had higher baseline TSIGA levels compared to those who did not develop arthritisConclusion: Circulating secretory immunoglobulins were elevated before and during the onset of RA .
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Front Immunol: Antcin K inhibits the expression of TNF-α, IL-1, and IL-8 in synovial fibroblasts and improves cartilage degradation
Time of Update: 2022-01-21
RASFs are considered to be the major catabolites of cartilage-bone degradation because they stimulate the production of pro-inflammatory cytokines associated with RA disease, including tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1b), IL- 8 and IL-6 .
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European Medicines Agency warns of new adverse reactions to methotrexate!
Time of Update: 2022-01-21
3 SummarizeIn summary , folic acid therapy (1 mg/d) is recommended for all patients on long-term low-dose methotrexate use .
The effect of folic acid supplementation on the toxicity of low-dose methotrexate in patients with rheumatoid arthritis[J].
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Front Immunol: Tocilizumab reduces angiogenesis in rheumatoid arthritis by regulating miR-146a-5p and EMMPRIN/CD147
Time of Update: 2022-01-21
After culturing HT1080 fibroblasts and U937 monocytes in vitro, the accumulation of the pro-angiogenic factors EMMPRIN, VEGF and MMP-9 was increased, whereas the accumulation of the anti-angiogenic factors thrombospondin-1 (TSP-1) and miR-146a- The expression level of 5p was decreased .
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Autoimmun Rev: Intravenous Immune Globulin Effectively Improves Skin Involvement in Systemic Sclerosis
Time of Update: 2022-01-21
, Intravenous immunoglobulins reduce skin thickness in systemic sclerosis: evidence from Systematic Literature Review and from real life experience .
Intravenous immunoglobulins reduce skin thickness in systemic sclerosis: evidence from Systematic Literature Review and from real life experienceleave a message here
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up to date!
Time of Update: 2022-01-21
1. General Guidelines Both guidelines for hyperuricemia in patients with gout and the overall guidance of the overall principle is similar, are referred to the importance of non-drug therapy, concerns related complications content and other aspects .
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How to reduce the risk of hypersensitivity reactions due to allopurinol?
Time of Update: 2022-01-21
In 2020, ACR's gout treatment guidelines and the newly released "Gout Grass-roots Rational Medication Guidelines" recommended allopurinol as a first-line uric acid-lowering drug, but allopurinol can cause fatal hypersensitivity reactions.
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Genetic research results are here!
Time of Update: 2022-01-21
We performed univariate and multivariate Mendelian randomization (MR) analyses using summary statistics from publicly published genome-wide association studies to estimate the causal relationship between sleep disturbance and OA risk .
Evidence for causal effects of sleep disturbances on risk for osteoarthritis: a univariable and multivariable Mendelian randomization study.
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JE: Qingluo Tongbi Recipe alleviates liver damage caused by Tripterygium wilfordii
Time of Update: 2022-01-21
Conclusion: Tripterygium wilfordii up- regulates LXRα to activate endoplasmic reticulum stress , increase the gene expression of SREBP-1c and lipid synthase, and lead to increased lipid synthesis in hepatocytes, which in turn leads to liver injury .
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Indomethacin, meloxicam, celecoxib... how to choose non-steroidal anti-inflammatory drugs for AS
Time of Update: 2022-01-21
What are the side effects of NSAIDs?Like any other drug, non-steroidal anti-inflammatory drugs can produce some adverse reactions when used for a long time .
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What does an MRI look for in patients with ankylosing spondylitis?
Time of Update: 2022-01-21
MRI manifestations of ankylosing spondylitis 0 1 1 sacroiliac joint sacroiliac joint①The early stage of the lesion is articular cartilage edema , with low signal on T1WI and high signal on T2WI after fat reduction.
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Front Immunol: Study of matrix metalloproteinase-9/gelatinase B in synovial fluid of rheumatoid arthritis
Time of Update: 2022-01-21
Conclusion: Rheumatoid arthritis synovial fluid contains higher levels of MMP-9, including truncated and citrulline-type proteins .
Rheumatoid arthritis synovial fluid contains higher levels of MMP-9, including truncated and citrulline-type proteins .
Proteoform Analysis of Matrix Metalloproteinase-9/Gelatinase B and Discovery of Its Citrullination in Rheumatoid Arthritis Synovial Fluids.
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Ann Rheum Dis: How safe is the SARS-CoV-2 vaccine in patients with rheumatic and musculoskeletal diseases?
Time of Update: 2022-01-21
immunityWe identified patients with I-RMD and non-inflammatory RMDs (NI-RMDs) who were vaccinated against SARS-CoV-2 between February 5, 2021, and July 27, 2021 from the Physician Report Registry, and collected Data on demographics , vaccinations, RMD diagnosis , disease activity, immunomodulatory/immunosuppressive therapy, episodes, adverse events (AEs), and SARS-CoV-2 breakthrough infection were presented .
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Autoimmun Rev: Factors associated with abnormal fertility in women with systemic lupus erythematosus
Time of Update: 2022-01-21
Nineteen studies reported that cyclophosphamide exposure (CYC) and its cumulative doses affected gonadal function in women with SLE, resulting in amenorrhea and POF .
