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JEM: Hu Xiaoyu's team from Tsinghua University revealed that CD127 regulates the heterogeneity of human monocyte inflammatory response
Time of Update: 2022-01-25
On January 11, 2022, Hu Xiaoyu's research group from the Institute of Immunology, Tsinghua University published a research paper online in the Journal of Experimental Medicine entitled: CD127 imprint
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How much uric acid can be controlled to reduce gout attacks?
Time of Update: 2022-01-25
The American College of Physicians Clinical Practice Guidelines: Management of Acute and Recurrent Gout [1] published in 2017 believe that most patients with gout for the first time, or patients with infrequent gout attacks, do not recommend long-term uric acid-lowering therapy .
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People with Down syndrome may be at high autoimmune risk due to accelerated immune system aging Science Translational Medicine
Time of Update: 2022-01-25
Click the blue text above to follow us Scientists have found that people with Down syndrome have an accelerated aging of the immune system, a finding that could explain the long-observed link between Down syndrome and autoimmune diseases .
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Once this organ is involved, is the risk of death significantly increased in patients with Sjögren's syndrome?
Time of Update: 2022-01-25
*Only for medical professionals to read the latest information on Sjögren's syndrome pulmonary lesions! Sjögren's syndrome (SS) is a diffuse autoimmune disease characterized by invasion of exocrine g
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Mol Cell Jiang Peng's research group reports that citrulline metabolism regulates the inflammatory response of macrophages
Time of Update: 2022-01-25
A recent study by Jiang Peng's group at the School of Life Sciences, Tsinghua University revealed that abnormal changes in the urea cycle significantly affect the ammonia metabolism and polyamine biosynthesis of tumor cells (Li et al.
006 Reprint notice [Non-original article] The copyright of this article belongs to the author of the article.
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Express FDA approves AbbVie's JAK inhibitor for atopic dermatitis
Time of Update: 2022-01-24
This is another JAK inhibitor approved by the FDA today for the treatment of atopic dermatitis (for another new drug, please refer to the headline report of WuXi AppTec today) .
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The master of camouflage of tumor cells: the effect of exosomes on the immune surveillance function of NK cells
Time of Update: 2022-01-24
However, release of NKG2DL in the extracellular milieu via protease-mediated cleavage or EV secretion is a mode of control of its cell surface expression and a mechanism by which cancer cells evade NKG2D-mediated immune surveillance .
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Men living alone suffer from pain... Study finds long-term living alone, too many breakups are associated with elevated levels of inflammation
Time of Update: 2022-01-24
In comparison, people who had experienced the most breakups had the highest levels of inflammatory markers in their bodies, 17 percent higher than those in the control group .
People who lived alone for more than seven years also had 12 percent higher levels of inflammation than the control group .
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One article teaches you to understand the spectrum of antinuclear antibodies
Time of Update: 2022-01-23
Antinuclear antibodies will cause damage to DNA, RNA, protein and other substances in the nucleus , thereby affecting the physiological functions of cells and inducing various autoimmune related diseases.
Some of these antibodies are concentrated in a certain autoimmune disease, which is specific and helpful for differential diagnosis .
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UK NICE recommends Rinvoq for psoriatic arthritis patients
Time of Update: 2022-01-22
The UK's National Institute for Health and Care Excellence (NICE) has issued a Final Assessment Decision (FAD) recommending Rinvoq (upadacitinib) as a new option for the treatment of adults with active psoriatic arthritis (PsA) .
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Autoimmun Rev: Myocarditis in Systemic Immune-Mediated Disease: Prevalence, Features, and Prognosis
Time of Update: 2022-01-22
Typical SIDS such as systemic lupus erythematosus (SLE), antiphospholipid syndrome (APS), systemic sclerosis (SSC), sarcoidosis, dermal polymyositis (DPM), eosinophilic granulomatosis with polyangiitis (EGPA) and other vasculitic syndromes may also be associated with myocarditis, as may organ-based immune-mediated diseases such as chronic inflammatory bowel disease (Ibds) .
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Front Cell Dev Biol: HSA_CIRC_0000652 aggravates the inflammatory response in ankylosing spondylitis by activating macrophages and enhancing OX40/OX40L interaction
Time of Update: 2022-01-22
Numerous studies have shown that circRNAs are differentially expressed and function in various rheumatic and inflammatory diseases, such as osteoarthritis (OA), systemic lupus erythematosus, and rheumatoid arthritis .
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ARD: Baseline Predictors of Treatment Success in Different Types of Rheumatoid Arthritis
Time of Update: 2022-01-22
Methods : Investigators used data from three rheumatoid arthritis (RA) trials (one for the primary analysis and two for the validation) to analyze patient and disease characteristics, core set measures, and composite index pairs to achieve different outcomes Effects of: response outcome (percentage of patients achieving relative response range); status outcome (remission or low disease activity, LDA ) and change outcome (numerical change on a metric scale) .
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Antioxidants (Basel): The role of flavonoids in propolis in anti-photoaging and psoriasis
Time of Update: 2022-01-22
An example of a naturally sourced substance with potential to treat skin diseases is propolis, a natural resin product made by honeybees using materials obtained from a variety of plant sources, which can be used to treat diseases caused by various factors such as UV rays or psoriasis.
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ESR, complement, important indicators of systemic lupus erythematosus activity!
Time of Update: 2022-01-22
During SLE disease activity and infection , a large number of immune complexes can be produced and deposited in tissues and organs, thereby activating the complement system and removing immune complexes through the alternative pathway of complement .
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Taking care of patients with IgG4-related diseases, we should be more careful with the screening of these two types of tumors!
Time of Update: 2022-01-22
Meta-analysis resultsAll studies reported overall SIR for malignancies .
Only 4 articles calculated SIR for organ-specific malignancies, and 3 studies reported SIR 1 year before and after IgG4-RD diagnosis .
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Cell Prolif: LncRNA-AK137033 regulates the Wnt signaling pathway through DNA methylation and inhibits the osteogenic potential of adipose-derived stem cells in diabetic osteoporosis
Time of Update: 2022-01-21
LncRNA-AK137033 inhibits the osteogenic potential of adipose-derived stem cells in diabetic osteoporosis by regulating Wnt signaling pathway via DNA methylation.
LncRNA-AK137033 inhibits the osteogenic potential of adipose-derived stem cells in diabetic osteoporosis by regulating Wnt signaling pathway via DNA methylation.
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Front Immunol: differential protection of biologics against systemic bone loss in rheumatoid arthritis
Time of Update: 2022-01-21
prevention Objective: To compare the changes of bone mineral density (BMD) in patients with rheumatoid arthritis (RA) after three years of conventional synthetic antirheumatic drug (CsDMARD), tumor necrosis factor inhibitor (TNFi), and abafibrate .
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Front Immunol: Fibroblast-stromal cell markers predict imaging progression in active rheumatoid arthritis
Time of Update: 2022-01-21
diagnostic immunization Objective: This study aimed to investigate whether the addition of fibroblast-stromal cell markers to the classification of synovial pathological types could improve their predictive value for clinical prognosis in rheumatoid arthritis (RA) .
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Rheumatology: These Comorbidities of Sjögren's Syndrome You Need to Know
Time of Update: 2022-01-21
musculoskeletal complications Clinical studies have shown that the prevalence of fibromyalgia in patients with pSS is about 12-31% , which is higher than that of the general population and significantly higher than that of other systemic autoimmune diseases such as SLE .
