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Immunity: The antigenic drift of the new coronavirus is 10 times faster than that of the influenza A virus!
Time of Update: 2022-01-27
Antigenic drift refers to the evolutionary accumulation of amino acid substitutions in viral proteins that retain variants that favor them as the virus moves through the population due to selection by the host's adaptive immune system .
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Children's inflammatory myopathy is frequently misdiagnosed, 3 diagnosis and treatment experiences save little lives!
Time of Update: 2022-01-27
JDM is a chronic inflammatory myopathy that affects the skin, striated muscle, and other tissues and organs (including the digestive tract, heart, and lungs) in patients aged 0-15 years .
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How is sarcoidosis diagnosed and differentially diagnosed?
Time of Update: 2022-01-27
For patients with symptomatic pulmonary sarcoidosis who are treated with glucocorticoids or other immunosuppressive agents and whose disease persists, are considered to have a higher risk of future death or permanent disability, we recommend the addition of infliximab to improve and/or maintain FVC and QoL .
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How to choose medicine for "gout + hyperlipidemia"?
Time of Update: 2022-01-27
Therefore, both doctors and pharmacists should master the essence of evidence-based medication and answer various questions according to the actual situation of patients .
Jie Xiaoyao has prepared 3 clinical medication questions to test everyone's medication knowledge and see how many you can answer correctly?
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inventory!
Time of Update: 2022-01-27
At this CRA annual meeting, Professor Zhao Dongbao, director of the Department of Rheumatology and Immunology, Changhai Hospital Affiliated to Naval Military Medical University, gave a detailed account of the "new progress in vitamin D research" .
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"Freeze to death" immune cells may save autoimmune diseases
Time of Update: 2022-01-26
By studying mouse models of multiple sclerosis, researchers have uncovered how exposure to cold temperatures prompts the body to use the immune system's resources to maintain body temperature and improve disease symptoms .
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"Nature" sub-issue: Mom gave more than just antibodies!
Time of Update: 2022-01-26
Roager of the Technical University of Denmark, through sequencing analysis of the microbiota and metabolites in fecal samples of infants and young children, as well as a series of in vitro culture experiments, revealed that the bifidobacteria in the infant intestines pass through Aromatic lactate dehydrogenase (ALDH) converts carbohydrates and aromatic amino acids in breast milk into aromatic lactate, a mechanism that regulates immune cell function .
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STTT major discovery!
Time of Update: 2022-01-26
On January 5, 2022, Xu Zhijian, Zhu Weiliang and Gong Likun of the Shanghai Institute of Materia Medica, Chinese Academy of Sciences jointly published an online article entitled "SARS-CoV-2 Omicron RBD shows weaker binding affinity than the currently dominant Delta variant to human ACE2", which showed that the Omicron variant has comparable binding affinity to human ACE2 compared to the wild-type SARS-CoV-2 by both molecular dynamics simulations and ELISA bioassay results , but much weaker than the Delta variant .
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up to date!
Time of Update: 2022-01-26
In GIOP follow-up treatment, adult patients who are still on hormonal therapy, fracture after bisphosphonate therapy for ≥18 months, or have a significant decrease in BMD (≥10%/year), conditionally recommend calcium and (active) On the basis of vitamin D, other types of anti-osteoporosis drugs should be used.
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The application of methotrexate, rheumatoid arthritis patients have to know the precautions!
Time of Update: 2022-01-26
The recommendations of the "2018 Chinese Guidelines for the Diagnosis and Treatment of Rheumatoid Arthritis" clearly point out that, once RA patients are diagnosed, they should start treatment with traditional synthetic disease-modifying antirheumatic drugs (csDMARDs) as soon as possible .
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AS: Discovery of a new subset of immunosuppressive neutrophils in gastric cancer microenvironment and revealing the regulatory effect mechanism
Time of Update: 2022-01-26
Innovation point: The research group of the National Engineering Research Center for Immunobiological Products has discovered a new subset of FasL+ PD-L2+ immunosuppressive neutrophils in the gastric cancer microenvironment, revealing its inducing regulatory mechanism and immunopathological effect mechanism, providing new insights for gastric cancer immune intervention.
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Sci Immunol Peng Hua/Fu Yangxin modified interleukin-12 to better activate tumor-infiltrating lymphocytes and reduce side effects to treat tumors
Time of Update: 2022-01-26
Editor's note iNature is China's largest academic public account. It is jointly created by doctoral teams from Tsinghua University, Harvard University, Chinese Academy of Sciences and other units.
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A low-purine diet is not necessarily suitable for gout patients. The latest recommendation should be this way!
Time of Update: 2022-01-26
03 The contradiction of gout diet control Generally speaking, long-term intake of purine-rich foods is not recommended clinically; although some purine-rich foods (such as fish rich in omega-3 fatty acids, red wine) short-term intake can lead to Gout attacks, but moderate intake can bring cardiometabolic benefits to gout patients .
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[Cell Sub-Journal] Researchers discover the mechanism that controls the formation of tertiary lymphoid structures of prognostic "potential stocks"!
Time of Update: 2022-01-25
Moffitt Cancer Center researchers recently published an article in Immunity titled: "TGF-β-mediated silencing of genomic organizer SATB1 promotes Tfh cell differentiation and formation of intra-tumoral tertiary lymphoid structures .
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Turning cold tumors into heat, Peking University Wu Hong's team revealed a new mechanism of prostate cancer immunotherapy
Time of Update: 2022-01-25
In this latest study, Wu Hong's group further found that intermittent administration of BAY1082439 can up-regulate cancer cell antigen presentation and T cell chemokine expression by inhibiting the PI3K-regulated immunosuppressive pathway, and reduce regulatory T cell mediators in tumors.
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Cell sub-issue: Jiang Peng's team from Tsinghua University reports that citrulline metabolism regulates macrophage inflammatory response
Time of Update: 2022-01-25
A recent study by Jiang Peng's group at the School of Life Sciences, Tsinghua University revealed that abnormal changes in the urea cycle significantly affect the ammonia metabolism and polyamine biosynthesis of tumor cells (Li et al.
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So complete!
Time of Update: 2022-01-25
For the treatment of gout flares in patients with mild to moderate hepatic impairment, no adjustment of the recommended dose is required, but patients should be closely monitored for adverse effects of colchicine .
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Professor Zhang Fengchun: Inventory of targeted B cell therapy programs for lupus, why did you choose the "Chinese program"?
Time of Update: 2022-01-25
Figure 1: The roles of various immune cells in the pathogenesis of SLE According to our current research findings, what are the targeted drugs that can be used in the clinical treatment of SLE?
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JEM: Tsinghua University Qi Hai team revealed that germinal center reaction without T cells produces antibody immune memory
Time of Update: 2022-01-25
On January 12, 2022, Qi Hai's research group from the Institute of Immunology, Tsinghua University published a research paper online in the Journal of Experimental Medicine titled: T-independent antigen induces humoral memory through germinal centers, which revealed the germinal center response The role of polysaccharide antigen in the induction of memory B cells and long-lasting plasmacytopoiesis .
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Case Sharing of Granulomatous Vasculitis "Unconventional"
Time of Update: 2022-01-25
13 After 1 week of anti-infective treatment, the chest CT plain scan in the other hospital was reviewed, and the bilateral lung lesions were higher than before Progress admission examination body temperature 36.
