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A&R: Variations in UBE2L3/YDJC autoimmune disease risk haplotypes increase UBE2L3 expression by modulating CCCTC-binding factor and YY1 binding
Time of Update: 2022-02-18
High-throughput sequencing of chromosome conformation capture combined with ChIP (HiChIP) and 3C-qPCR revealed a long-range interaction between the UBE2L3 promoter (rs140490 , rs140491 , rs11089620) and the downstream YDJC promoter (rs3747093 ) The /YDJC risk haplotype is enhanced and associated with loss of CCCTC- binding factor (CTCF) and increased YY1 binding on the risk allele .
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A&R: Magnetic Resonance Imaging for Evaluation of Subchondral Cysts and Sudden Knee Pain and Knee Osteoarthritis: Data from the Multicenter Osteoarthritis Study
Time of Update: 2022-02-18
Multiple logistic regression, adjusting for participant characteristics and other baseline knee MRI results, to assess whether subchondral cysts predict event outcomes .
Multiple logistic regression, adjusting for participant characteristics and other baseline knee MRI results, to assess whether subchondral cysts predict event outcomes .
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A&R: Anti-Double-Stranded DNA Antibodies Recognize DNA Presented on HLA Class II Molecules of Systemic Lupus Erythematosus Risk Alleles
Time of Update: 2022-02-18
Immunization This study aimed to test the hypothesis that DNA binds to HLA class II molecules in a manner similar to misfolded proteins , and that DNA bound to HLA class II molecules activates B cells by activating B cell receptors expressing anti- DNA , thereby Involved in the pathogenesis of SLE .
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Front Immunol: Association of history of non-typhoid salmonella with risk of systemic lupus erythematosus
Time of Update: 2022-02-18
Systemic lupus erythematosus (SLE) is one of the top 20 causes of death in women aged 5-64 years, and the multifactorial etiology of SLE, including genetic factors, immune dysfunction-related factors, environmental factors and hormonal factors, can be considered as the exposure group- Outcomes of epigenome-genome interactions .
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A&R: Effects of clonal expansion of PD-1highCXCR5-CD4+ peripheral T helper cells on articular B cell differentiation in patients with antinuclear antibody-positive juvenile idiopathic arthritis
Time of Update: 2022-02-18
Conclusions: Clonally expanded CD4+ Tph cells accumulate in the joints of ANA -positive JIA patients, especially promoting CD21 low/ low/ – – CD11c+ DN B cell differentiation .
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A&R: Multiple variants of soluble CD146 are associated with systemic sclerosis: identification of a novel profibrotic factor
Time of Update: 2022-02-17
Since CD146 also exists in a circulating soluble form (sCD146) and acts as a growth factor in many angiogenesis and inflammation-related pathologies, this study sought to determine the mechanism by which sCD146 is produced and characterize the regulation and function of the different identified variants .
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Front Immunol: a novel serum tsRNA for the diagnosis and prediction of systemic lupus erythematosus nephritis
Time of Update: 2022-02-17
The current diagnosis of systemic lupus erythematosus (SLE) mainly relies on clinical manifestations and laboratory tests, including antinuclear antibodies (ANA), anti-double-stranded DNA (anti-dsDNA) and anti-Smith antigen (anti-Sm) .
Here, we determined whether the characterization of tsRNAs in serum could serve as diagnostic or prognostic biomarkers for systemic lupus erythematosus (SLE) .
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Front Immunol: Novel effects of combination therapy in the induction of pyroptosis in lupus nephritis by inhibiting Caspase-1/Gasdermin D
Time of Update: 2022-02-17
The inhibitory effect of combination therapy on caspase-1/GSDMD-induced pyroptosis was observed in MRL/LPR mice and human specimens .
Combination therapy inhibits disease progression by inhibiting caspase-1/GSDMD-mediated pyroptosis in humans and MRL/LPR mice .
Combination therapy inhibits caspase-1/GSDMD-mediated pyroptosis and delays disease progression in vitro and in vivo .
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Emerg Microbes Infect: A multicenter cross-sectional study on the prevalence and risk factors of active pulmonary tuberculosis in patients with rheumatic disease
Time of Update: 2022-02-17
Emerg Microbes Infect 2021 Nov 10;Liu X, Zhang L, Zhang F,Prevalence and Risk Factors of Active Tuberculosis in Patients with Rheumatic Diseases: A Multi-center, Cross-Sectional Study in China.
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A&R: Semaphorin3B plays a central role in serum-induced arthritis model and is reduced in rheumatoid arthritis patients
Time of Update: 2022-02-17
Sema(phorin) 3B was previously found to reduce the migratory and invasive abilities of rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) and inhibit the expression of matrix metalloproteinases (MMPs) .
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Front Immunol: cellular and molecular phenotypes of pConsensus Peptide (pCons)-induced lupus CD8+ and CD4+ regulatory T cells
Time of Update: 2022-02-17
Investigating the genes, regulatory networks, and signaling pathways underlying CD8 + T reg cell functional activity and survival is important for developing therapeutics to restore immune homeostasis in SLE and other autoimmune diseases .
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ARD: Targeting the IL-6-Yap-Snail signaling axis in synovial fibroblasts improves inflammatory arthritis
Time of Update: 2022-02-17
Gdf5- lineage SFs showed increased Yap expression and exhibited an aggressive phenotype ( podoplanin+Thy-1 cell surface antigen- ) that invaded cartilage and bone .
Conditional ablation of Yap Yap in Gdf5 Gdf5 lineage cells Or fibroblasts expressing Pdgfr Pdgfrαα can improve AIA .
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ARD: The anti-fibrotic factor KLF4 is inhibited by the miR-10/TFAP2A/TBX5 axis in dermal fibroblasts
Time of Update: 2022-02-17
Results: This study revealed distinct differentially expressed and methylated genes, including several transcription factors involved in stem cell differentiation and developmental programs ( KLF4 , TBX5 , TFAP2A and HOXB3 , HOXB8 isobox genes ) .
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Br J Dermatol: Prevalence and incidence of generalized pustular psoriasis in Sweden
Time of Update: 2022-02-17
GPP is more common in women than in men, and it appears that the male-to-female ratio is between 0.
The cases are associated with the Swedish General Population Register with an estimated point prevalence of 31 December 2015 .
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Ther Adv Musculoskelet Dis: Epidemiology and risk of invasive fungal infection in systemic lupus erythematosus:
Time of Update: 2022-02-17
In conclusion, this nationwide population-based cohort study revealed a high risk of IFI infection and mortality in patients with lupus erythematosus, including a high risk in juvenile lupus erythematosus patients .
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[Case Interpretation] What should I do if the tophi ruptures?
Time of Update: 2022-02-17
In the event of an emergency tophi rupture, it is difficult to do aseptic treatment at home, and secondly, it is difficult to clean up these corrosive uric acid crystals by yourself, the wound is difficult to recover, and even becomes infected .
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Clin Pharmacol Ther: Innovative Pediatric Development Pathway for Secukinumab in Psoriasis
Time of Update: 2022-02-17
For all three endpoints and both Seckinumab regimens, the observed treatment effects from the pediatric trial in severe psoriasis (12 weeks after randomization) were included within the 95% confidence intervals of their respective predicted distributions, which were only From adult data .
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ARD: The human SLE variant NCF1-R90H promotes renal injury and lupus murine through macrophage-deficient exocytosis to induce enhanced Tfh2 responses
Time of Update: 2022-02-17
CONCLUSIONS: The lupus pathogenic variant NCF1-H90 reduces macrophage burial, enhances Tfh2 responses, and promotes autoantibody production and renal injury in mice and SLE patients .
CONCLUSIONS: The lupus pathogenic variant NCF1-H90 reduces macrophage burial, enhances Tfh2 responses, and promotes autoantibody production and renal injury in mice and SLE patients .
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Severe "blood phagocytosis" - a rare group of critically ill patients, where is the diagnosis and treatment broken?
Time of Update: 2022-01-27
Figure 1 The relationship between the number of patients with organ failure and mortality [n(%)] How should the diagnosis and treatment of severe HLH be carried out?
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Cell Metabolism Coenzyme A promotes the antitumor effect of T cells
Time of Update: 2022-01-27
In addition, the metabolic profile of CD8+ T cells treated with coenzyme A changed, and the level of oxidative phosphorylation was significantly increased .
