-
Inflammation may explain differences in susceptivity in the population to severe COVID-19.
Time of Update: 2020-10-06
!--webeditor:page title" -- September 22, 2020 / -- COVID-19 infection levels can vary greatly, with some people having no symptoms at all, others life-threatening and others vulnerable to very seriou
-
NEJM: COVID19 rapid detection promises to improve accuracy.
Time of Update: 2020-10-06
study published in the journal New England Journal of Medicine, researchers showed that in a group of patient samples, they tested positive for 93 percent of the cases, determined by PCR testing COVID-19.
-
Cell: Reveals the characteristics of systemic inflammation and antibody response in children with multi-system inflammatory syndrome.
Time of Update: 2020-10-06
results were published online September 14, 2020 in the journal Cell, under the title "Mapping Systems And Antibody Responses in MultisystemSysySysy Syndrome in Children (MIS-C)." analysis of cytokines in these MIS-C patients identified elevated characteristics of inflammation (IL-18 and IL-6), lymphocyte and myelin cell activation and activation (CCL3, CCL4, and CDCP1), and mucosal immunodeficiration (IL-17A, CCL20, CCL28).
-
Uncovering how a special class of lethal T-cells can get out of control during the onset of inflammatory bowel disease?
Time of Update: 2020-10-06
Photo Source: University of Cambridge researchers have found that individuals with ulcerative colitis have higher numbers and proportions of TRM belonging to the four different varieties mentioned above, a cell type they call inflammatory TRM, which produces large amounts of cytokines and protein factors and helps kill other types of cells, and that high levels of specific cytokines induce inflammation and tissue damage in the body.
-
AJHG: Heavy! Scientists have discovered for the first time that there is an appearanceal genetic defect or prevalence in the human genome!
Time of Update: 2020-10-06
Photo Source: Pixabay/CC0 Public Domain researcher Andrew Sharp says that because it is not ability to detect oscic genetic mutations through genome sequencing, but these mutations can lead to abnormal or silent gene expression, which is closely related to the occurrence of genetic diseases, the results of this study suggest that certain types of pathogenic mutations may be ignored and missed by standard genetic testing that only observes DNA sequences.
-
Magic! On the same day, Nature published three papers on cGAS, and Science published two cGAS papers that revealed the mechanism by which nuclear gadgets bind to inhibit cGAS to block autoimmune responses.
Time of Update: 2020-10-06
4. Science: In a new study, researchers at the University of North Carolina at Chapel Hill identified for the first time a high-resolution structure in the congenital immune system in which a key DNA-sensing protein called cGAS binds to a nucleosome, where the nucleosome is the most important DNA packaging unit in the nucleus.
-
Lancet Rheumatol: Watch out! Using hydroxychloroquine and azithromycin at the same time may increase an individual's risk of cardiovascular disease!
Time of Update: 2020-10-06
In the article, the researchers said that in the largest ever safety study comparing hydroxychloroquine treatment with hydroxychloroquine in patients treating rheumatoid arthritis, they found that the combination of hydroxychloroquine and azithromycin was directly related to a significant increase in the risk of cardiovascular disease, including mortality, and that hydroxychloroquine is commonly used to treat rheumatoid arthritis, a commonly used antibiotic used to treat infections such as pneumonia, chest and sinusitis.
-
Cell: Chinese scientists have structurally revealed that BD-368-2 antibodies can effectively treat hamsters severely infected with the new coronavirus.
Time of Update: 2020-10-06
results were published online September 14, 2020 in the journal Cell under the title "Structurally resolved SARS-CoV-2 antibody show high efficacy in severely infected hamsters and provides a potent cocktail pairing strategy." , BD-368-2 treated infected adult hamsters with low doses and different treatment windows, while infected hamsters treated with placebos showed severe interstitio pneumonia.
-
Science Sub-Journal: Heavy! A new system can accurately analyze chromosome telomeres in 3 hours!
Time of Update: 2020-10-06
September 22, 2020 // -- Scientists from the National University of Singapore and other institutions have developed a new system that can accurately analyze telomeres in three hours in a study published in the international journal Science Advances entitled "Massively parallel single-product telomere with digital real-time PCR".
-
Chinese scientists have revealed key kinases that regulate T-cell failure.
Time of Update: 2020-10-06
by further detecting the correlation between MAP4K1 and other inhibitory ligenes in tumor-invasive T-cells, MAP4K1 was positively related to T-cell failure signals (CD3E, TIGIT, PDCD1, CTLA4, HAVCR2, and LAG3) in different cancer patients, and HPK1 expression in inhibited and HPK1 proteins in tumor specimens was also found to be increased.
-
Cell Rep Med interpretation! New vaccine strategies may use T-cells to provide the body with protection against influenza virus infection.
Time of Update: 2020-10-05
!-- webeditor: page title-- September 27, 2020 // -- A recent publication in the international magazine Cell Reports Medicine entitled "MedicineProgramming Multifaceted Pul" In a study by Group Adjuvants, scientists from the University of Wisconsin-Madison and others developed a new vaccine strategy that uses T-cells to provide the body with immune protection against influenza.
-
Nature's deep interpretation! How scientists have identified dozens of key genes that help cancer cells evade attack by the host immune system!
Time of Update: 2020-10-05
September 27, 2020 // -- In a recent study published in the international journal Nature entitled "Functional genomic landscape cancer-intrinsic evasion of killing by T cells", scientists from the University of Toronto and other institutions identified dozens of genes that promote cancer cells to evade the host body's immune system.
-
The first high-eosinophil syndrome (HES) targeted biologic drugs! FDA approves GlaxoSmithKline's third allergy!
Time of Update: 2020-10-05
!--, 2020 / --- GlaxoSmithKline (GSK) recently announced that the U.S. Food and Drug Administration (FDA) has approved the anti-inflammatory drug Nucala (mepolizumab, Mepolizumab) A new adaptive disorder for the treatment of patients with high eosinophil syndrome (HES), specifically: HES lasts for up to 6 months, unrecognized non-hematological secondary causes, adults and pediatric patients aged 12 years.
-
Science: Super potent antibody mixture blocks the new coronavirus from attaching to host cells
Time of Update: 2020-10-05
In a new study, researchers from the United States, France, Belgium and Italy found that a super-powerful antibody mixture from recovering COVID-19 patients identified and blocked the infection complex of the pandemic coronavirus and prevented it from entering cells.
-
Thorax: Genetically induced elevated levels of serum biliary erythrin and the incidence of lung cancer.
Time of Update: 2020-10-05
Studies have shown that elevated levels of serum bilium are associated with a decrease in lung cancer, especially among smokers.
the strongest association among current smokers, bililin levels decreased by 10.2/10000 PY (95% CI 5.5-15.0) and MR estimated at 6.4/10000 PY (95% CI 1.4-11.5) for every increase in biligen levels.
-
The world's first long-acting C5 inhibitor! Ultomiris has been approved in Japan for its new adaptation: the treatment of atypical hemolytic uremic synthesis (aHUS)!
Time of Update: 2020-10-05
In the European Union, Ultomiris was approved in June this year for children and adults who had not previously received supplement inhibitor therapy (primary treatment) or had been treated with soliris (eculizumab) for at least 3 months and had evidence of a HUS in response to Soliris treatment, weighing more than 10 kg.
-
Cell: An effective antibody against the new coronavirus has been identified to protect infected hamsters from lung lesions.
Time of Update: 2020-10-05
a new study, researchers from the German Center for Neurodegenerative Diseases and berlin's Schalette School of Medicine identified highly effective antibodies against SARS-CoV-2 and are working on a passive immune strategy.
-
Ann Rheum Dis: Effects of the COVID-19 pandemic on the course of the disease in rheumatology patients.
Time of Update: 2020-10-05
study looked at whether a brief decrease in treatment for patients with central spinal arthritis (axSpA), rheumatoid arthritis (RA) or psoriasis arthritis (PsA) was associated with worsening of the disease during the new coronary pneumonia epidemic.
-
New drug for rheumatoid arthritis (RA)! Gilead's oral JAK1 inhibitor Jyseleca (filgotinib) is approved by the European Union and Japan!
Time of Update: 2020-10-05
-- -- Gilead and partner Galapagos NV recently jointly announced that the European Commission (EC) has approved Jyseleca (filgotinib, 200mg and 100mg tablets), an oral selective JAK1 inhibitor used to treat adult patients with moderate to severe rheumatoid arthritis (RA) who have inadequate or insatiable response to one or more disease-modified anti-rheumatoid drugs (DMARD).
-
The body's immune system may have another new function to --- depression.
Time of Update: 2020-10-05
25, 2020 /--- In a new study, researchers from yale University School of Medicine and other research institutions compared immune system cells in the spinal fluid of multiple sclerosis (MS) patients and healthy subjects and found that inflammatory autoimmune responses found in healthy people's spinal fluid were similar to autoimmune responses associated with neurodegenerative diseases such as multiple sclerosis.
