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Chinese scholars have made progress in the field of narrowband OLED research
Time of Update: 2022-10-25
In order to solve the key problem of efficiency roll-off, Professor Yang Chuluo's team of Shenzhen University synthesized BNSeSe by embedding non-metallic heavy atom selenium in a multi-resonance framework, and used the heavy atom effect to enhance the coupling between the mono- and trilinear (S1 and T1) orbitals of the material, so as to achieve extremely high kRISC (2.
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Infection studies: Antibodies prevent cell infection
Time of Update: 2022-10-25
A team of scientists around Professor Volkhard Kempf from the Institute of Microbiology and Hospital Hygiene at the University Hospital Frankfurt has now succeeded in blocking the adhesion mechanism of bacteria and thus preventing infection of host cells.
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Science mapped the key protein structure of the hepatitis C virus
Time of Update: 2022-10-25
"Article Structure of the hepatitis C virus E1E2 glycoprotein complex Image: A high-resolution image showing the full length of E1E2's complex with three broadly neutralizing antibodies from two angles.
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Researchers from the Institute of Microbiology collaborated to discover highly potent antibodies and super-neutralizing epitopes of yellow fever virus
Time of Update: 2022-10-25
In this study, 8 strains of antibodies bound to YFV-E protein were obtained, of which 2 strains had super neutralizing activity and had a highly effective therapeutic effect on mice infected with yellow fever virus.
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Researchers released the human genome structural variation database and computational analysis platform
Time of Update: 2022-10-25
SV provides high-quality population genomic structural variation data resources, greatly improves the detection and display of human genome structural variation information based on next-generation sequencing data, especially for the first time, it comprehensively covers the structural variation diversity of East Asian populations and Chinese populations, and provides annotations of related genes and potential clinical effects.
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Zhang Qiangfeng's team at Tsinghua University developed the online integration algorithm SCALEX for single-cell sequencing data
Time of Update: 2022-10-25
SCALEX uses an asymmetric autoencoder structure composed of batch-independent encoders and batch-specific decoders to obtain a highly generalized encoder through extensive learning, which eliminates batch effects while preserving biological differences by projecting high-dimensional single-cell sequencing data into the low-dimensional cell embedding space.
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Nature has been searching for a long time, and finally found proteins that directly promote the "ammunition depot" of neurotransmitters
Time of Update: 2022-10-25
Fast resupply of synaptic vesicles requires synaptotagmin-3 Scientists at Oregon Health & Science University have discovered a long-sought gene encoding protein that allows the brain to transmit a wide range of signals between gaps between neurons, called synapses.
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Gao Pu and Zhang Liguo and collaborators revealed the transmembrane transport mechanism of cyclic dinucleotide and folic acid
Time of Update: 2022-10-25
On October 20, 2022, the Gao Pu team, Zhang Liguo's team from the Institute of Biophysics of the Chinese Academy of Sciences and the Gao team from Beijing Institute of Technology published an article "Recognition of cyclic dinucleotides and folates by human SLC19A1" online in the journal Nature, unveiling the mystery of SLC19A1's identification of different substrate molecules 。 The researchers first performed extensive screening and obtained a series of murine monoclonal antibodies that recognize SLC19A1 to stabilize protein samples.
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New research provides new clues to the genetic cause of high cholesterol
Time of Update: 2022-10-25
Image credit: Dr. Jenna Carlson According to a new study conducted by geneticists at the University of Pittsburgh's School of Public Health in collaboration with other groups such as the University of Otago and the Samoa Health Research Group, a genetic variant that is relatively common in people of Polynesian ancestry but extremely rare in most other populations has been identified, providing clues to the genetic basis for high cholesterol in all people.
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Cell Rep: The assembly mechanism of microbial communities in metabolic division of labor
Time of Update: 2022-10-25
The famous economist Adam Smith pointed out in his classic book "The Wealth of Nations" that the division of labor is one of the main ways to increase labor productivity and increase national wealth.
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Both drugs reversed a key step in pancreatic cancer in the lab
Time of Update: 2022-10-25
The hidden nature of pancreatic cancer caught the attention of scientists at the University of Florida, who discovered a way to reverse a key cellular process in its development.
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Nucleic Acids Research: Questioning the safety of in vivo gene editing
Time of Update: 2022-10-25
In recent years, a new generation of gene editing tools such as CRISPR-Cas has shown great application prospects in the process of tumor immunotherapy and gene in vivo therapy. The optimization of ge
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Reverse drug resistance in lung cancer
Time of Update: 2022-10-25
Raghuraman Kannan (right) and a team of researchers at the University of Missouri recently received a $2.
Raghuraman Kannan (right) and a team of researchers at the University of Missouri recently received a $2.
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Science Non-Opioid Painkiller Milestones: Reduced Pain, No Side Effects and Addiction!
Time of Update: 2022-10-25
"In 2016, Professor Gmeiner, in collaboration with an international research team, discovered an active substance that binds to known opioid receptors and provides the same degree of pain relief as morphine, although it bears no chemical resemblance to opioids.
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Guangzhou Health Center has bred a model of pigs who are congenitally obese but free from diabetes
Time of Update: 2022-10-25
Schematic diagram of the mechanism of action of CREBRFR457Q point mutant pigs in promoting obesity and reducing type 2 diabetes Links to papers Recently, the Lai Liangxue research group of the Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences published online in the FASEB journal entitled Generation of a genetically modified pig model with CREBRFR457Q Variant's research paper.
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Uncover the unique pathway for monkey virus SV40 to sneak into the nucleus
Time of Update: 2022-10-25
A team of researchers at the University of Michigan School of Medicine conducted an in-depth study of how the polyomavirus SV40 enters the nuclear membrane and found that two major nuclear membrane protein complexes – LINC and NPC – work synergistically to drive the prototype polyomavirus SV40 into the nucleus.
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The ancestors of this fruit are more interesting and complex than imagined
Time of Update: 2022-10-25
An extensive genetic analysis of more than 100 species of wild and cultivated bananas uncovered the tangled history of bananas during domestication, revealing the existence of three previously unknown ancestors who may still be alive.
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The gut microbiota improves nonalcoholic steatohepatitis aggravated by smoking by degrading nicotine
Time of Update: 2022-10-25
Tobacco use is the leading preventable cause of disease and death globally. China's direct smoking population exceeds 300 million, and the number of people passively exposed to the smoke environment
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The NIH allocated $4.6 million to better identify lung cancer
Time of Update: 2022-10-25
His goal is to develop and validate innovative biomarkers extracted from nasal swabs, blood, and advanced imaging assays to identify intermediate-risk lung nodules detected through screening or as part of routine clinical care as lung cancer.
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PNAS Cognitive Processing Innovation Theory: In addition to neurons, astrocytes are also involved in memory and behavior
Time of Update: 2022-10-25
"New research paves way for innovative theory of cognitive processing Textbooks we are familiar with generally describe the role of glial cells as follows: (1) providing scaffolding for neuronal growth; (2) Formation of an insulating layer (myelin sheath) around neurons, so that nerve impulses can be transmitted quickly; (3) Deliver nutrients to neurons and remove excessive neurotransmitters between neurons.
