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Cell: Don't fight, "nothing to do with mosquitoes" these people are born to attract mosquitoes!
Time of Update: 2022-11-05
That's why Vosshall and Maria Elena De Obaldia, a former postdoc in her lab, set out to explore the main theory that explains changes in mosquito attraction: changes in individual odors are related to skin flora.
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The new experimental method IR-DOSY reveals the structure and size of the molecule
Time of Update: 2022-11-05
Figure: IR-dosy spectra of a mixture of acetone and dialanine, showing which IR peak belongs to which compoundResearchers at the University of Amsterdam have developed a new infrared spectroscopy method that can simultaneously characterize the structure and size of molecules.
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The State Food and Drug Administration replied to "artificial blood development": It is of great significance, and if it meets the requirements, the review can be accelerated
Time of Update: 2022-11-05
China News Network, October 26 The website of the State Food and Drug Administration released the "Letter on the Reply to the Proposal No. 4278 (Political and Legal No. 314) of the Fifth Meeting of t
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Science: Gut-derived genotoxic metabolites have been linked to cancer
Time of Update: 2022-11-05
"essayCommensal microbiota from patients with inflammatory bowel disease produce genotoxic metabolites According to a new study, functional screening of the human gut microbiota has revealed the presence of a family of small molecule genotoxins called indolamine in patients with inflammatory bowel disease (IBD).
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CCIN mutations cause teratozoospermia and male infertility
Time of Update: 2022-11-05
Figure: CCIN mutant sperm head malformation is severe and cannot adhere to the zona pellucida, which eventually leads to male infertility, which can be successfully overcome by ICSI.
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Small: Application of nanozymes in the treatment of cardiovascular and cerebrovascular diseases
Time of Update: 2022-11-05
Recently, researchers from Nanjing University published a review article entitled Nanozyme-Enabled Treatment of Cardio- and Cerebrovascular Diseases in the journal Small, which will provide some guiding prospects for the research of nanozymes and promote the development of mimicking enzyme strategies in the treatment of cardiovascular and cerebrovascular diseases.
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New anti-cancer compounds are introduced
Time of Update: 2022-11-05
Chemical Communications, 2022; 58 (73): 10237 A team of researchers at the University of Kentucky's Markey Cancer Center has developed a new compound that promises to be a potential anti-cancer therapy to treat aggressive tumors.
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Stem cell-derived organoids mimic human parathyroid tissue
Time of Update: 2022-11-05
A study published Oct. 27 in the journal Stem Cell Reports suggests that patient-derived parathyroid organoids (PTOs) may pave the way for future physiological studies and drug screening applications.
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Science sub-journal: Scientists have discovered a novel RNA target and tool to help ward off premature human aging
Time of Update: 2022-11-05
Constitutive heterochromatin is primarily responsible for genomic inhibition of DNA rich in repeats, telomeres, and centrioles 。 Recently, a research paper published in the international journal Science Translational Medicine entitled "LINE-1 RNA causes heterochromatin erosion and is a target for amelioration of senescent phenotypes in progeroid syndromes", Scientists from institutions such as King Abdullah University of Science and Technology have discovered a new type of RNA target and tool to ward off premature aging.
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Bispecific antibodies for ophthalmology! Two Phase 3 studies of Vabysmo for retinal vein occlusion (RVO) were successful!
Time of Update: 2022-11-05
Levi Garraway, Roche's Chief Medical Officer and Head of Global Product Development, said: "These encouraging data suggest that Vabysmo has the potential to offer a new treatment option for patients with retinal vein occlusion (RVO), a serious retinal vascular disease that can lead to irreversible visual impairment or vision loss.
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The team of academician Lu Lin of Peking University Sixth Hospital proposed a new strategy to prevent opioid relapse
Time of Update: 2022-11-05
" This study proposes and validates a new method of preventing opioid relapse, the methadone-initiated memory reconsolidation updating procedure (MMRUP) based on methadone, and realizes the transformation of results from animal research to clinical trials.
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The team of Wang Shiyong and Zhuang Xiaodong of Shanghai Jiaotong University realized the precise construction of molecular quantum magnets
Time of Update: 2022-11-05
Figure 2 Left: Chemical structure of molecular quantum magnets, Right: End fractional spin observed by spectroscopyThe researchers combined three different synthesis methods to efficiently realize the construction of molecular quantum magnets, and developed a new method for efficient preparation of low-dimensional magnetic systems.
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PNAS: Scientists have developed novel therapies that promise to inhibit the growth of prostate cancer in humans
Time of Update: 2022-11-05
Scientists from institutions such as Baylor College of Medicine have revealed the molecular mechanisms driving the growth of advanced prostate tumors tolerant to standard castration therapy. Androgen
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Nature Biotechnology's Wang Jing research group developed m6A single-base quantitative sequencing detection method
Time of Update: 2022-11-05
Glyoxal and nitrite-mediated deamination of unmethylated adenosine (GLORI) (Glyoxal and nitrite-mediated deamination of unmethylated adenosine) developed by Wang Jing's research group Breaking through the limitations of the above technologies, it has achieved the first true sense of high efficiency, high sensitivity, high specificity, and no preference for single-base m6A site detection The modification level of them6A site is absolutely quantified.
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The Zhu Ting research group of the College of Life Sciences realized mirror T7 transcription
Time of Update: 2022-11-05
In order to break through the limitation of protein size by total chemical synthesis, the researchers used the strategy of splitting protein to synthesize three fragments of T7 RNA polymerase with a total length of 883 amino acids with a length of 363, 238 and 282 amino acids, respectively, and jointly renatured them in vitro to correctly fold them into a 100 kDa high-fidelity mirror T7 RNA polymerase with complete function (Figure 1).
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【Research News】Liu Jianfeng's team from the School of Life Sciences, Huazhong University of Science and Technology found that GPCR oligomers lead to a new mechanism of biased activation
Time of Update: 2022-11-05
On October 26, 2022, Professor Jianfeng's research team from the School of Life Sciences and the Key Laboratory of Molecular Biophysics of the Ministry of Education published an online publication en
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【Scientific Research News】Pure mRNA from Shangri-La——Zhu Bin's research group of Huake University discovered a new RNA synthesis tool enzyme
Time of Update: 2022-11-05
On October 26, 2022, Professor Zhu Bin's team from the School of Life Sciences, Huazhong University of Science and Technology, published a report entitled "Psychrophilic phage VSW-3 RNA polymerase reduces both terminal and full-length dsRNA byproducts in in vitro", a well-known international journal in the field of RNA transcription".
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A new clue to a serious neurodegenerative disease
Time of Update: 2022-11-05
The new findings provide insight into the fundamental biology of frontotemporal dementia, a devastating neurodegenerative disease caused by mutations in specific genesThe researchers found that an in
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Qinghai: Major breakthrough in the control of echinococcosis
Time of Update: 2022-11-05
(End) Xining, October 26 (Chen Peng, Zhang Tianfu) A reporter from China News Network learned from the Plateau Medical Research Center of Qinghai University on the 26th that the latest research result of the center's Professor Ge Rili team "Evaluation of the effect of the use of multilocular echinococcus leucine aminopeptidase in the targeted treatment of alveolar echinococcosis" marks that researchers have found an effective means to inhibit the development of "worm cancer".
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Why immunotherapy works for some cancer patients and not others
Time of Update: 2022-11-05
In an analysis of a phase 2 clinical trial of the immunotherapy drug pembrolizumab in 24 patients with endometrial cancer, the Yale team found that the specific mechanism of DNA repair defects in tumors was a key determinant of patient outcomes.
