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Rare reversible cerebral atrophy
Time of Update: 2022-11-14
”References:Winter conditions, not resource availability alone, may drive reversible seasonal skull size changes in moles The researchers discovered another mammal with a shrunken brain.
”References:Winter conditions, not resource availability alone, may drive reversible seasonal skull size changes in moles The researchers discovered another mammal with a shrunken brain.
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Women are protected from some form of cell death
Time of Update: 2022-11-14
Further experiments showed that chemical activation of NRF2 could protect male kidney cells from iron prolapse, suggesting that NRF2 may be a potential therapeutic target for preventing renal repair failure after acute kidney injury.
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iScience: New insights into the pathogenesis of diabetes
Time of Update: 2022-11-14
Article Soluble T-cadherin promotes pancreatic β-cell proliferation by upregulating Notch signaling Figure: Soluble T-cadherin is a new secretory factor that promotes the proliferation of pancreatic β cells in times of insulin deficiency.
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Removing toxic "protein clumps"
Time of Update: 2022-11-14
Using super-resolution microscopy, the team showed that when neurons were exposed to a mutated version of the Tau protein in frontotemporal dementia, the aggregation of the Fyn enzyme was enhanced, potentially triggering a debilitating chain reaction.
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The healthier the furniture, the lower the PFAS level
Time of Update: 2022-11-14
Our findings provide much-needed scientific evidence for the success of health materials – which don't have to be more expensive or inferior in performance – as a realistic solution to reducing indoor exposure to permanent chemicals," said Anna Young, a research associate in the Department of Environmental Health, associate director of the Healthy Buildings Project and lead author of the study.
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Structural Variability Information Analysis Platform for Drug Transporters (VARIDT 2.0)
Time of Update: 2022-11-14
In October 2022, Professor Zhu Feng and Professor Zeng Su of Zhejiang University and Professor Chen Yuzhang of Tsinghua University published the "drug-" for all drugs in Nucleic Acids Research, an important journal in the field of biomedicine Molecular Interaction Atlas" and developed DrugMAP, the world's first data platform to describe this type of atlas.
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The team of Zhao Yilei of Shanghai Jiaotong University proved the effectiveness of biosynthase pre-reactive state analysis based on artificial intelligence
Time of Update: 2022-11-14
Recently, Cell Press Cell Reports Physical Science published online the research team of Professor Zhao Yilei of the School of Life Science and Technology of Shanghai Jiao Tong University entitled "U
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Tumor targets Serine protease matrix enzymes inhibit the migration and proliferation of multiple myeloma cells
Time of Update: 2022-11-14
"Article The serine protease matriptase inhibits migration and proliferation in multiple myeloma cells Figure 5: Stromal enzyme expression in patient samples is associated with myeloma cell survival.
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The Bailinquan team of Shanghai Jiaotong University analyzed the crystal structure and catalytic mechanism of novel carbamoyltransferase
Time of Update: 2022-11-14
Recently, the team of Professor Bai Linquan of the School of Life Science and Technology of Shanghai Jiao Tong University published an online publication entitled "Endowing homodimeric carbamoyltransferase GdmN with iterative functions through structural characterization and" in the international authoritative journal Nature Communications Mechanistic Studies".
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South China Botanical Garden reveals the ecological mechanism of microbial regulation of soil organic carbon sequestration in tropical coastal forest restoration
Time of Update: 2022-11-14
Based on the 60-year-old vegetation restoration sequence of Xiaoliang Tropical Coastal Ecosystem Positioning Research Station, the restoration ecology task team of South China Botanical Garden of the Chinese Academy of Sciences explored the accumulation characteristics of balloon mycin-related soil proteins and aminosugars and the contribution of soil organic carbon pool in the process of vegetation restoration.
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Elevated carbon dioxide levels can lead to a lack of minerals in plants, leading to fewer nutritious crops
Time of Update: 2022-11-14
Alain Gojon, research director and first author of the French National Institute of Agriculture, Food and Environment, said: "There are many reports in the literature that suggest that CO2 levels expected by the end of the 21st century will lead to lower concentrations of nitrogen in most plants, mainly affecting the protein content in plant products.
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Chen Xingdong's team systematically analyzed the causal association between NAFLD and 34 extrahepatic diseases
Time of Update: 2022-11-14
In order to screen for qualified instrumental variables, the researchers conducted three rounds of Mendelian randomization analysis and found a significant and robust causal association between NAFLD and nine diseases, including type 2 diabetes, hypertension, myocardial infarction, and Alzheimer's disease (Figure 2).
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Novel gene-editing therapies offer hope for patients with thyroxine amyloid cardiomyopathy
Time of Update: 2022-11-14
A single intravenous infusion of NTLA-2001, a novel CRISPR/cas9-based gene-editing therapy, significantly reduces circulating transthyretine (TTR) protein levels in patients with ATTR amyloid cardiomyopathy, a progressive and fatal cause of heart failure, according to the latest research presented today at the American Heart Association's 2022 Scientific Meeting.
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Cancer Cell: FOXA2 drives the mechanism of prostate tumor cell plasticity and activation of the KIT signaling pathway
Time of Update: 2022-11-14
On November 3, the international academic journal Cancer Cell published online a research paper entitled "FOXA2 drives lineage plasticity and KIT pathway activation in neuroendocrine prostate cancer"
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Neuron: Growing motor neurons are guided by a vascular "love-hate relationship"
Time of Update: 2022-11-14
essayMotor neurons use push-pull signals to direct vascular remodeling critical for their connectivity Image: In the image on the left, motor neurons (green) open a pathway for developing healthy mice as they grow toward muscle in their blood vessels (red).
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Cell research Shanghai Drug revealed the structural basis of frogetin family receptors to recognize itch polypeptides
Time of Update: 2022-11-14
On November 3, 2022, the team of Xu Huaqiang/Yin Wanchao of the Shanghai Institute of Materia Medica, Chinese Academy of Sciences, published the research results entitled "Molecular recognition of itch-associated neuropeptides by bombesin receptors" online on Cell Research 。 This achievement is the first to report that the frogetin family receptor Neuromedin B receptor (NMBR) and Gastrin-releasing peptide receptor (GRPR) bind endogenous polypeptide ligands - neuromedin B (NMB) and gastrin-releasing peptide (GRP), respectively.
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IHMT-CSF1R-833 was found to be a potent and selective CSF1R inhibitor
Time of Update: 2022-11-14
14 nM, which inhibits phosphorylation of CSF1R and its downstream signaling pathway in a dose-dependent manner.
14 nM, which inhibits phosphorylation of CSF1R and its downstream signaling pathway in a dose-dependent manner.
14 nM, which inhibits phosphorylation of CSF1R and its downstream signaling pathway in a dose-dependent manner.
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Nature Immunology: Identification of long-lived plasma cell taxa
Time of Update: 2022-11-14
On October 31, 2022, the Qi Hai Research Group of the Institute of Immunology, School of Medicine, Tsinghua University, and Wang Jianbin's Research Group, School of Life Sciences, Tsinghua University
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The researchers found that airborne polluting particles were linked to cardiac arrest
Time of Update: 2022-11-14
The research team, which included members from the National Energy Administration's Environmental Health Institute and the Clean Environment Group's Environmental Monitoring and Modeling Unit, evaluated whether there was a correlation between out-of-hospital cardiac arrest (OHCA) and levels of tiny air pollution particles (at least 25 times smaller than the width of a hair).
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The COVID-19 virus disrupts the normal mixing of gut bacteria, increasing the risk of other infections
Time of Update: 2022-11-14
Gut microbiome dysbiosis in antibiotic-treated COVID-19 patients is associated with microbial translocation and bacteremia A new study has found that infection with the pandemic virus SARS-CoV-2 reduces the number of bacterial species in patients' guts, and less diversity creates space for dangerous microbes to multiply.
