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Science Advances: Changes in cell behavior after neuroblastoma drug resistance
Time of Update: 2022-11-26
”essayClinically relevant treatment of the PDX model shows a pattern of chemoresistance in neuroblastoma Researchers at Lund University in Sweden have discovered one of the reasons why neuroblastomas in children become resistant to chemotherapy.
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Professor Chen Jinjun's team of Southern Hospital has published two new results in the Journal of Hepatology, an international authoritative academic journal
Time of Update: 2022-11-26
The above research results were completed under the funding of the 13th Five-Year Infectious Major Project of the Ministry of Science and Technology and the National Key R&D Program, which is a landmark achievement of the infectious medicine team in the field of end-stage liver disease and non-invasive diagnosis of portal hypertension.
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Novel mechanism by which extracellular matrix protein Nidogen-2 inhibits vascular calcification
Time of Update: 2022-11-26
On November 10, 2022, Professor Kong Wei of the Department of Physiology and Pathophysiology of Peking University School of Basic Medical Sciences, in collaboration with Professor Sun Jinpeng, published an online title in the internationally renowned cardiovascular journal Circulation Research The research paper "Nidogen-2 is a novel endogenous ligand of LGR4 to Inhibit Vascular Calcification" reveals the extracellular matrix protein Nidogen-2 as a result A novel endogenous biased ligand of LGR4 inhibits a novel mechanism of vascular calcification.
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A leap forward in personalized cancer therapy! CRISPR-engineered T cells for clinical trials
Time of Update: 2022-11-26
They isolated T cells from 16 patients, most of whom had colorectal cancer, and used CRISPR to convert their endogenous T cell receptor (TCR) genes into genes that were more specific for cancer, allowing immune cells to better target tumors.
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The Alzheimer's disease risk variant APOE4 is associated with impaired myelin assembly
Time of Update: 2022-11-26
As neuroscientist Li-Huei Tsai and her colleagues at the Massachusetts Institute of Technology (MIT) in Cambridge report today in the journal Nature, APOE4 prompts the central nervous system cells that produce myelin insulators — oligodendrocytes — to falsely accumulate cholesterol inside cells, interfering with the normal function of oligodendrocytes—their ability to coat nerve fibers with a lipid-rich myelin protective membrane.
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Exploring the nasal-brain pathway for nasal administration to the brain: delivering antidepressants via the trigeminal nerve
Time of Update: 2022-11-26
Intranasal administration has received increasing attention as a method of non-invasive delivery of drugs directly to the brain. This method evades the blood-brain barrier and delivers drugs directly
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? The team of Xinyu Zhang in the School of Public Health of Biomolecules found that bilirubin is degraded by neutrophils...
Time of Update: 2022-11-26
Bilirubin, the end product of heme degradation, is a strong physiological antioxidant that significantly reduces the risk of many diseases such as cardiovascular disease, diabetes, and cancer. Biliru
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The first successfully transplanted genetically modified pig heart underwent unexpected electrical changes
Time of Update: 2022-11-26
Image credit: University of Maryland School of MedicineTen months after transplanting the first genetically modified pig heart into a human patient, researchers at the University of Maryland School of Medicine (UMSOM) continue to report new findings from this landmark transplant.
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Jia Yanxing's team has made important breakthroughs in the field of total synthesis of natural products
Time of Update: 2022-11-26
On October 24, 2022, Jia Yanxing's team from the State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmacy, Peking University, was published in the internationally renowned journal Journal of the American Chemical Society The latest research results in the field of total synthesis of natural products, "Total Synthesis of (?).
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Mysterious soil virus genes
Time of Update: 2022-11-26
"References:Structural characterization of a soil viral auxiliary metabolic gene product – a functional chitosanase The researchers believe that the virus AMG in the study encodes an enzyme that performs a degradation reaction on chitin.
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Gossycin found in hibiscus can treat Alzheimer's disease
Time of Update: 2022-11-26
”Gossypetin ameliorates 5xFAD spatial learning and memory through enhanced phagocytosis against Aβ Gossyptin and Alzheimer's disease affect changes in brain tissue.
”Gossypetin ameliorates 5xFAD spatial learning and memory through enhanced phagocytosis against Aβ Gossyptin and Alzheimer's disease affect changes in brain tissue.
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Is this really a miracle medicine for weight loss? The study found important results that contradicted the results of previous experiments
Time of Update: 2022-11-26
Image: According to a new study conducted by researchers at Okayama University, the species-specific expression pattern of the NMU gene is responsible for different functions in rats and mice.
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Nature Medicine: There are advances in the early diagnosis of Alzheimer's disease
Time of Update: 2022-11-26
Co-corresponding author Professor Oskar Hansson of Lund University said: "The brain undergoes changes 10 to 20 years before the patient develops obvious symptoms, and only when the tau protein begins to spread, the nerve cells die, and the patient has cognitive problems for the first time.
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Molecular mechanisms underlying selective degradation of mitochondrial tRNA leading to HUPRA syndrome
Time of Update: 2022-11-26
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Professor Yang Shengyong's team published an article in Nature Communications to reveal a molecular generative model based on deep learning, and found that RIPK1 inhibitors have been studied...
Time of Update: 2022-11-26
Recently, the team of Professor Shengyong Yang of the Biotherapeutic Research Center of our hospital published an article in Nature Communications, a sub-journal of the journal Nature, revealing the
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Top journals in the field of dentistry published the research results of Professor Xu Shulan's team in the Stomatological Hospital and broadcast the papers
Time of Update: 2022-11-26
Prospective cohort research results of Professor Xu Shulan's team Recently, the Journal of Periodontology (JP, CAS Subcategory 1) published the latest research results of Xu Shulan's team in the Stomatology Hospital, "Periodontitis and cognitive impairment in older adults: The mediating role of mitochondrial dysfunction" 。 The study was conducted by Prof.
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Nature Medicine: Smart watch electrocardiograms can accurately detect heart failure in non-clinical settings
Time of Update: 2022-11-26
Two health technology advancements: an app and back-end infrastructure that lets patients share smartwatch ECG data remotely with their clinicians in a simple and secure way, and modifies a proven 12-lead ECG artificial intelligence (AI) algorithm to enable it to run on single-lead watch ECG recording.
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Studies have found that ancient diseases have the potential to regenerate the liver?!
Time of Update: 2022-11-26
"Article in vivo Partial Reprogramming by Bacteria Promotes Adult Liver Organ Growth without Fibrosis and Tumorigenesis Leprosy is one of the oldest and most persistent diseases in the world, but the bacteria that cause leprosy may also have a surprising ability to grow and regenerate vital organs.
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Jiang's team of researchers published an article in Emotion to reveal the impact of awe on self-continuity
Time of Update: 2022-11-26
Researcher Tonglin Jiang and collaborators explored the impact of awe on self-continuity through six different studies.
Researcher Tonglin Jiang and collaborators explored the impact of awe on self-continuity through six different studies.
Researcher Tonglin Jiang and collaborators explored the impact of awe on self-continuity through six different studies.
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JAMA: For the first time, it has been confirmed that mindfulness-based stress reduction (MBSR) is equivalent to escitalopram in reducing anxiety!
Time of Update: 2022-11-26
In conclusion, mindfulness-based stress reduction therapy (MBSR) proved to be a well-tolerated treatment option in this research trial, with efficacy comparable to first-line medications for patients with anxiety disorders.
