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Nature: Revealing microglia helps protect brain health and cognitive performance
Time of Update: 2022-12-30
Lead author Dr Niamh McNamara, a researcher at the University of Edinburgh, said: "We lack treatments that can effectively slow or stop the progression of dementia.
Lead author Dr Niamh McNamara, a researcher at the University of Edinburgh, said: "We lack treatments that can effectively slow or stop the progression of dementia.
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Why is the colorectal cancer signaling pathway bypassed?
Time of Update: 2022-12-30
”On October 19, 2022, a new research paper was published in Volume 13 of Oncotarget, titled "Platelet-derived growth factor (PDGF) cross-signaling via non-corresponding receptors indicates bypassed signaling in colorectal cancer"In addition to growth factor-mediated signaling pathways such as vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF), platelet-derived growth factor (PDGF) signaling pathways appear to play a crucial role in tumor development and development.
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Gene therapy can correct mutations in common heart diseases
Time of Update: 2022-12-30
Using the CRISPR-Cas9 gene-editing system, researchers at the University of Texas Southwestern corrected mutations in human cells and in mouse models of the disease that lead to a common inherited heart condition called dilated cardiomyopathy (DCM).
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An important transcription factor "FoxH1" mechanism of action
Time of Update: 2022-12-30
She added: "The structural details we found in this work may enable the development of specific molecules that interact with FoxH1 and, in the future, potentially lead to drugs to treat diseases in which this protein plays a key role.
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The FDA approved the "luminescent tumor" imaging drug to help with lung cancer surgery
Time of Update: 2022-12-30
Thoracic surgeons at the Center for Precision Surgery at Abramson Cancer Center at the University of Pennsylvania, in collaboration with Indiana-based manufacturer On Target Laboratories, led clinical trials evaluating imaging agents for lung cancer 。 This is the second approval for Cytalux, which was approved for ovarian cancer surgery last year and is also based on clinical research, and the University of Pennsylvania School of Medicine leads one of the largest research centers in the country.
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PNAS is a way to make asthma medications last longer
Time of Update: 2022-12-30
Dr. Deshpande's team at the Center for Translational Medicine is looking for a way to alter the way receptors capture β agonists.
Dr. Deshpande's team at the Center for Translational Medicine is looking for a way to alter the way receptors capture β agonists.
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Science: Innovative therapies show hope, mother's mitochondria can refresh the cells of sick children
Time of Update: 2022-12-30
A team of researchers is testing a strategy to soak a patient's blood cells in a "nourishing soup" of the mother's healthy mitochondria before reinfusing them.
A team of researchers is testing a strategy to soak a patient's blood cells in a "nourishing soup" of the mother's healthy mitochondria before reinfusing them.
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Preprint: Models predict that the coronavirus outbreak in China could cause 1 million deaths
Time of Update: 2022-12-30
"However, two studies have found that deaths could be reduced by giving most people a fourth dose of the vaccine, as well as high adherence to mask wearing and re-imposing temporary restrictions on social interactions when mortality soars.
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Whole genome sequencing showed that the telomeres of white blood cells in "IVF" were short in length
Time of Update: 2022-12-30
Blastocyst stage embryo transfer results in shortening of mouse telomere length on day 1 postnatal (P=2.
Blastocyst stage embryo transfer results in shortening of mouse telomere length on day 1 postnatal (P=2.
Blastocyst stage embryo transfer results in shortening of mouse telomere length on day 1 postnatal (P=2.
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Two articles prove that a new drug can fight both COVID and cancer
Time of Update: 2022-12-30
”The role of GRP78 in virus transmissionIn search of a more stable way to fight COVID-19, Lee and her colleagues at the Keck School of Medicine at USC and the Cleveland Clinic Florida Research and Innovation Center set out to study the role of GRP78, a key cell chaperone protein that helps regulate the folding of other cellular proteins.
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Groups of people in cancer that "trick" cells
Time of Update: 2022-12-30
Lactate-dependent chaperone-mediated autophagy induces oscillatory HIF-1α activity promoting proliferation of hypoxic cells Researchers at the University of Connecticut Health Center, Yale University and Johns Hopkins University have found that some cancer cells can "trick" into allowing cancer cells to continue to grow by evading the restrictions imposed by the lack of oxygen.
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The world's first COVID-19 screening system with a high sensitivity of 97%, surpassing antigen detection!
Time of Update: 2022-12-30
A machine learning COVID-19 mass screening based on symptoms and a simple olfactory test Wash your hands with hydrogel and smell it, then answer a short questionnaire with a QR code.
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Nature sub-issue: Regenerative "muscle" response
Time of Update: 2022-12-30
essayBiasing the conformation of ELMO2 reveals that myoblast fusion can be exploited to improve muscle regeneration "Until recently, myoblast fusion was the subject of basic research," says Dr. Cté.
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Research explores how plague spreads in wild rodent populations
Time of Update: 2022-12-30
According to a study published this week in the journal Animal Science, fleas infected early alone are not enough to cause animal epidemics in most wild rodents, but rather favor a more stable endemic state, done by Joseph Hinnebusch of the Rocky Mountain Laboratory at the National Institute of Allergy and Infectious Diseases, and colleagues.
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Research and application progress of RNA interference technology for pest control
Time of Update: 2022-12-30
Recently, Tang Xueming's team from the School of Agriculture and Biology of Shanghai Jiao Tong University published a review article entitled "RNAi-based pest control: Production, application and the fate of dsRNA" in Frontiers in Bioengineering and Biotechnology 。 This paper comprehensively and systematically reviews the research and application progress of RNA interference technology for pest control, mainly including: (1) the synthesis and construction of dsRNA and large-scale production methods.
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A neuroimaging feature can be used to predict the intensity of drug and food cravings
Time of Update: 2022-12-30
(End) BEIJING, Dec. 20 (ZXIN) -- A new paper published in Nature Neuroscience, a professional academic journal owned by Springer Nature, reports a neuroimaging feature that can be used to predict the intensity of drug and food cravings.
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COVID-19 respiratory mucosal DNA vaccine is effective in mice
Time of Update: 2022-12-30
Respiratory mucosal vaccination of peptide-poloxamine-DNA nanoparticles provides complete protection against lethal SARS-CoV-2 challenge Pulmonary vaccine-induced immune response and protection against SARS-CoV-2 virus.
Respiratory mucosal vaccination of peptide-poloxamine-DNA nanoparticles provides complete protection against lethal SARS-CoV-2 challenge
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Nature: A new way to kill cancer cells
Time of Update: 2022-12-30
Erwin tested the molecule in cells from Friedrich ataxia patients and found that Syn-TEF1 successfully targeted repeat amplification, helping RNA polymerase transcribe the FXN gene through it, returning frataxin to normal levels.
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The South China Botanical Garden reveals the temporal and spatial law of carbon, nitrogen and phosphorus retention time in forest ecosystems
Time of Update: 2022-12-30
The input and output of material elements is not only the need to maintain the operation and development of the ecosystem itself, but also the concrete embodiment of the realization of ecosystem func
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Bioengineered synthetic gene circuitry enhances cancer immunotherapy
Time of Update: 2022-12-30
In two separate studies, researchers have shown how synthetic biology can be used to solve a conundrum in cancer immunotherapy: Immunotherapy-related approaches focused on killing tumor cells in a wa
