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At least 80% of opioid overdose are not fatal, but how do they affect the brain?
Time of Update: 2021-09-13
To better understand this topic, researchers at West Virginia University School of Medicine and Rockefeller Neuroscience Institute (Erin Winstanley) and James Mayo James Mahoney reviewed 79 studies of neurocognitive disorders and brain abnormalities related to non-fatal opioid overdose .
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Zhu Xinguang's research team found that the canopy space occupied volume is a new indicator of crop light energy utilization efficiency
Time of Update: 2021-09-13
This new research first developed a corn organ segmentation algorithm based on 3D point cloud data, and then used the segmented plant leaf point cloud to virtually change structural features such as leaf angle and leaf size through coordinate conversion; adjust the light response curve to change the physiological Indicators to create "new genotypes" .
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Interdisciplinary research shows cells "feng shui"
Time of Update: 2021-09-13
Adele Doyle, an assistant professor at the University of California, Santa Barbara, joined the Life Physics Cluster (PoL) in July 2021, leading the Stem Cell Mechanobiology Research Group at the University of Dresden .
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New discovery: Chinese scientists have discovered the core regulator of malaria transmission
Time of Update: 2021-09-13
The results showed that PfAP2-G5 can be combined with The upstream region and the exon gene body combine to inhibit the transcriptional activity of pfap2-g (the key gene for plasmodium sex conversion).
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Research shows that many sea surface climates will disappear in 2100
Time of Update: 2021-09-13
In order to assess the future climate, the fifth assessment report of the United Nations Intergovernmental Panel on Climate Change adopted four greenhouse gas concentration scenarios, ranked RCP2.
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First discovery: Rare MX1 mutation increases human susceptibility to H7N9 virus
Time of Update: 2021-09-13
The formation of antiviral inactive MxA hetero-oligomers leads to dominant negative effectsThis study found for the first time that rare mutations in the MX1 gene can increase the risk of human infection with the avian influenza virus .
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What makes blood vessels leaky: new insights into the treatment of sepsis
Time of Update: 2021-09-13
By paying more attention to the downstream-not on the main GPCR, but on the single target of its action, such as HSP27-Trejo's team hopes to develop more precise drugs that stabilize the vascular barrier with fewer side effects .
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Overview of the development of mRNA vaccines: part two
Time of Update: 2021-09-13
Figure 5 Representative LNP structure and ionizable lipids in preclinical research and clinical trials Production of mRNA vaccinesOnce the pathogen is identified or the outbreak is announced, the genome of the pathogen and antigen will be determined through joint sequencing, bioinformatics and computational methods (if not already) .
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Hong Kong's marine ecosystem in the past 100 years
Time of Update: 2021-09-13
He said: “Climate change, especially the weakening of the East Asian summer monsoon, has led to a decrease in rainwater and freshwater discharge in the Pearl River, which will have a significant impact on marine life in the eastern waters of Hong Kong, such as Dapeng Bay and Sai Kung .
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MicroRNA noise reduction mechanism and accurate tumor cell recognition
Time of Update: 2021-09-13
Recently, based on the research idea of "digital-carbon-based fusion", Wang Xiaowo's research group from the Department of Automation of Tsinghua University revealed the gene expression noise reduction mechanism of microRNA and applied it to synthetic gene circuits Design, by guiding the construction of an artificial gene cell classifier, the precise identification of tumor cells has been achieved .
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Genes can respond to the encoded information in the signal, or they can be completely filtered out
Time of Update: 2021-09-13
The researchers also found that they can control the number of genes that can respond to different signals by controlling the number and types of proteins attached to the promoter region of a gene .
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Significantly reduce liver fibrosis mRNA therapy shows therapeutic potential
Time of Update: 2021-09-13
It is reported that this study provides preclinical data for the first time, proving the applicability of mRNA therapy encoding HNF4A transcription factor in the treatment of liver fibrosis and cirrhosis .
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More "against the sky" than graphene, scientists have created a double-layer boronene material for the first time
Time of Update: 2021-09-13
Science and Technology Daily, Beijing, August 26 (intern reporter Zhang Jiaxin) According to the latest research published in the journal Nature Materials on the 26th, Northwestern University engineers created for the first time a two-layer atomic-thick borene, breaking the boron The natural tendency to form non-planar clusters outside the limit of a single atomic layer .
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PNAS: Why are older people more susceptible to cancer?
Time of Update: 2021-09-13
Recently, researchers from the Japan Association for Cancer Research and Genetics published a research report titled "Pericentromeric noncoding RNA changes DNA binding of CTCF and inflammatory gene expression in senescence and cancer" in the Proceedings of the National Academy of Sciences (PNAS) , Reveals how aging promotes cancer .
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Science Sub-Journal: Treatment of rheumatoid arthritis with drug-releasing implanted cells
Time of Update: 2021-09-13
Louis used genetic engineering techniques to implant cells into mice to release biological drugs to deal with inflammation .
"Doctors often use injections or injections of anti-inflammatory biological drugs to treat patients with rheumatoid arthritis, but when these drugs are used long enough and in large enough doses, significant side effects can occur," said senior researcher Dr.
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Southeast University's latest article: new progress has been made in the field of peripheral nerve injury repair
Time of Update: 2021-09-13
The protein loading and release capacity and biological effects of SCPAPPy conductive hydrogel nerve conduit With funding from the National Natural Science Foundation of China (approval number: 81830040), Professor Zhang Zhijun’s research group from Southeast University proposed a new therapy for repairing peripheral nerve damage with microfluidic hollow fibers combined with non-invasive electromagnetic induction and controlled-release nerve growth factor.
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PNAS blockbuster: Cholesterol affects Alzheimer's disease plaque deposition treatment of new opportunities will be born
Time of Update: 2021-09-13
Related research results were published on PNAS under the title Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol .
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Innovative therapy to effectively improve the height of children with "dwarfism" approved by the European Union
Time of Update: 2021-09-13
In phase 3 clinical trials, vosoritide can effectively promote bone growth in children with achondroplasia, and it is still effective one year after injection .
Reference materials:[1] European Commission Approves BioMarin's Voxzogo® (vosoritide) for the Treatment of Children with Achondroplasia from Age 2 Until Growth Plates Close.
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Chinese scholar Nature's sub-Journal reveals the molecular mechanism of the new RdDM pathway
Time of Update: 2021-09-13
In this study, researchers through genome-wide methylation sequencing and differentially methylated regions (DMRs) analysis found that the flowering regulatory gene FVE can affect the DNA methylation level of some of the regulatory sites of the RdDM pathway .
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Junshi/Lilly's new crown neutralizing antibody cocktail therapy resumes distribution in the United States
Time of Update: 2021-09-13
1. 351), which directly affects the subsequent sales of Eli Lilly's new crown neutralizing antibody .
However, due to the pandemic of the Delta mutant strain, Eli Lilly/Junshi's new crown neutralizing antibody cocktail therapy is effective for the mutant strain .
