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88% objective response rate bispecific antibody preliminary clinical results released
Time of Update: 2021-09-19
In patients with relapsed/refractory DLCBL who received RP2D therapy (n=8), the preliminary efficacy results reported in the trial showed that the patients achieved an overall response rate (ORR) of 88% and a complete response (CR) of 38% .
Reference materials:[1] Clinical Trial of Investigational Epcoritamab (DuoBody®-CD3xCD20) in Patients with Relapsed/Refractory B-cell non-Hodgkin's Lymphoma (B-NHL) Published in The Lancet.
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Phase 3 clinical trial of cell therapy for the treatment of severe complications of diabetes yields positive mid-term results
Time of Update: 2021-09-19
On September 8, Ixaka announced that its ongoing autologous multi-cell therapy (MCT) REX-001 has achieved positive interim results in a phase 3 clinical trial .
Note: The original text has been deletedReference materials:[1] Ixaka announces positive interim Phase 3 clinical trial data for its lead cell therapy candidate REX-001.
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Patients with multiple sclerosis show strong T cell responses to mRNA COVID-19 vaccine
Time of Update: 2021-09-19
New research shows that multiple sclerosis (MS) patients receiving anti-cd20 (aCD20) treatment can produce a strong T cell response to the mRNA COVID-19 vaccine, despite the silent antibody response to the vaccine .
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Nature Materials: New gel helps easy cultivation of pancreatic organoids
Time of Update: 2021-09-19
Scientists from the Massachusetts Institute of Technology and the University of Manchester have developed a new method that uses healthy or cancerous pancreatic cells to grow pancreatic organoids .
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The team of academician Lu Lin reveals that the intestinal flora is involved in mediating cognitive impairment caused by sleep deprivation
Time of Update: 2021-09-19
Research pattern diagramRecently, Molecular Psychiatry, a top journal in the field of psychiatry, published an online research paper entitled " Gut microbiota modulates the inflammatory response and cognitive impairment induced by sleep deprivation " by the team of Academician Lu Lin from Peking University Sixth Hospital .
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Researchers have discovered a new role in acute myeloid leukemia
Time of Update: 2021-09-19
Picture: Ze'ev Ronai is the director of the Sanford Burnham prebyys cancer center designated by nciSource: Sanford Burnham prebyysA new study led by scientists at Sanford Burnham Prebis University shows that the protein RNF5 plays an unusual role in acute myeloid leukemia (AML) .
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Autism research breakthrough: high degree of heterogeneity
Time of Update: 2021-09-19
In a paper published in the journal Communications Biology, her laboratory demonstrated certain basic brain states in preschool children diagnosed with autism spectrum disorder (ASD), especially their The dynamics have been disrupted .
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Research and development of new tools for calculating T cells may quickly predict cancer patients' response to therapy
Time of Update: 2021-09-19
Recently, in a research report entitled "Using DNA sequencing data to quantify T cell fraction and therapy response" published in the international journal Nature, scientists from the University of London and other institutions have developed a new type of tool through research, or It can quickly estimate the number of immune T cells in cancerous tumors.
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White blood cells "have two brushes" that can help destroy malignant tumors
Time of Update: 2021-09-19
Picture: Proliferation of metastatic tumor cells in animals without eosinophilsSource: Tel Aviv UniversityA new study from Tel Aviv University found that eosinophils-a type of white blood cell-are recruited to fight cancer metastasis in the lungs .
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Increase in serotonin prevents mice from becoming addicted to cocaine
Time of Update: 2021-09-19
Researchers report that elevated serotonin levels can prevent mice from compulsive seeking and addiction to cocaine .
In this study, Yue Li and his colleagues reported that they discovered a mechanism that revealed the modulating effect of serotonin in preventing compulsive cocaine seeking and addiction in mice .
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Studies have found that the persistent presence of antibodies in COVID-19 patients can reduce the risk of reinfection for up to six months
Time of Update: 2021-09-19
Charles Schuler, MD, the first author of the paper and a clinical assistant professor of allergy and immunology at the University of Michigan Medical School, said: "In the past, people were very worried that only those patients with severe COVID-19 would have a strong infection.
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Scientific research shows that supplementing vitamin E, coenzyme Q10 and glutathione can reverse the heart damage caused by cancer
Time of Update: 2021-09-19
Adding specific types of antioxidants to the food eaten by tumor-bearing fruit flies can reverse the damage to the heart-this finding suggests that the damage caused by free radicals may be a link between cancer and heart dysfunction .
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Nature: Scientists are expected to develop non-opioid analgesics to treat human chronic pain
Time of Update: 2021-09-19
Recently, in a research report entitled "Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesia" published in the international journal Nature, scientists from Monash University and other institutions have achieved a major research breakthrough, or development New non-opioid analgesics provide new ideas for safe and effective treatment of neuropathic pain .
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Nature Genetics: Breast cancer can be divided into 9 "ecotypes"
Time of Update: 2021-09-19
A research team led by the Gavin Institute of Medical Research in Australia has revealed a new method of classifying breast cancer subtypes based on cell atlases, which may help patients with personalized treatment .
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Neurologists study the link between COVID and "brain fog" dementia
Time of Update: 2021-09-19
A new study from Rutgers University will examine how COVID-19 affects individuals in a number of cognitive-related fields, including memory loss, "brain fog" and dementia .
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Science: "Noisy" gene expression plays a key role in development!
Time of Update: 2021-09-19
While studying HIV, Weinberger's team discovered the existence of some molecules that can increase noise or switch the expression mechanism between active and inactive states, but strangely, they do not affect the average expression level .
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Newly discovered how transcription factors work
Time of Update: 2021-09-19
In order for molecular processes to actually use this information, chromatin is "turned on" so that DNA can be bound by transcription factors, which are proteins that help translate DNA sequences composed of base pairs (or "letters") into messenger RNA (mRNA) .
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Scientists explore the creation of artificial organelles
Time of Update: 2021-09-19
The team demonstrated this multi-enzyme biocatalytic cascade function by encapsulating glucose oxidase (GOx) and horseradish peroxidase (HRP) in exosomes .
Armed with this knowledge, the research team tried to create functional artificial mitochondria that can produce energy in cells .
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"Science" prevents the long-term effects of traumatic brain injury
Time of Update: 2021-09-19
So, understand how traumatic brain injury affects the brain, especially in In the long term, this is a very important gap in research that can help develop new and better treatment options .
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Obtained FDA Fast Track Qualification, Innovative Inhaled Antibiotic Therapy Reached Phase 3 Clinical Endpoint
Time of Update: 2021-09-19
A few days ago, Zambon announced that it will use its I-neb adaptive inhalation aerosol delivery system to deliver CMS sodium, a phase 3 clinical trial PROMIS-I in non-cystic fibrosis bronchiectasis (NCFB) patients.
Compared with placebo, the annual incidence of acute exacerbations in NCFB patients in the CMS I-neb group was significantly reduced (0.
