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Science Sub-Journal: New methods to understand protein dynamics and cell process regulation
Time of Update: 2021-09-19
Source: Francesco Colizzi (IRB Barcelona)Cellular processes are regulated by the balance between different protein shapes, which give these molecules active or inactive functions .
Modesto Orozco, have developed a new computational program that can discover and quantify the shape of functional proteins, thereby revealing the molecular details of cellular processes .
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Chinese scholar PNAS published a paper: New discovery of cell mitochondria helps fight many diseases
Time of Update: 2021-09-19
Zhen Yan has been seeking a better understanding of how mitochondria work for many years, and he called this new discovery the most exciting of his career .
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Cell Feng Shui: The unification of physical and biochemical cues creates a healthy organism
Time of Update: 2021-09-19
The new research team at the Dresden University of Technology aims to reveal how stem cells respond to mechanical forces and electrical signals during the development and maintenance of the nervous and cardiovascular systems .
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The essential component of the main protein component of the extracellular environment: tRNA modifying enzyme
Time of Update: 2021-09-19
Lluís Ribas de Pouplana, have discovered a trna-modified protein called ADAT, which is a key role in the production of a group of proteins targeting the extracellular environment .
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Nature reveals: Children's outstanding performance in response to the new crown, Delta strain, makes "supernatural power" disappear
Time of Update: 2021-09-19
Adults have been trained to become more powerful in their immune systems during previous pathogen infections and vaccination processes, and they are more "handy at dealing with new pathogens" "The outstanding performance of children and young people in response to the new crown surprises the outside world .
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Amino-substituted pyrazolo betulinic acid anti-osteoarthritis compound discovered by JMC Shanghai Pharmaceuticals
Time of Update: 2021-09-19
Recently, the joint team of Yang Chunhao, Zuo Jianping and He Shijun of the Shanghai Institute of Materia Medica, Chinese Academy of Sciences synthesized a new type of betulinic acid (Betulinic acid, BA) derivative, which was proven to significantly relieve arthritis through a classic animal model of osteoarthritis.
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Chao Daiyin's research team discovered key genes for iron content in plant seeds, which is expected to solve the "hidden hunger" problem
Time of Update: 2021-09-19
September 4, 2021, Science sub-Journal Science Advances issued Innovation Center for Molecular Plant Sciences, Chinese Academy of Excellence Chao-generation Indian research group entitled "NPF transporters in synaptic-like vesicles control delivery of iron and copper to seeds" of research papers .
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Hypoxia promotes linear ubiquitination of AGO2 to regulate tumorigenesis and development
Time of Update: 2021-09-19
On September 13, 2021, the team of Yu Jianxiu /Cheng Jinke/Chen Guoqiang from Shanghai Jiaotong University School of Medicine published in Nature Communications the latest research results titled Hypoxia regulates overall mRNA homeostasis by inducing Met1-linked linear ubiquitination of AGO2 in cancer cells .
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Chinese scholars have made progress in the field of research on the prevention, control and management of major infectious diseases
Time of Update: 2021-09-19
Figure 1 The spatio-temporal evolution characteristics of HBV infection in pregnant women nationwide from 2015 to 2020 With funding from the National Natural Science Foundation of China
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Research honored in "Science": "Fixed Frame" Dynamic Assembly of Mitochondrial Membrane Protein Complex
Time of Update: 2021-09-19
The team led by Professor Yin Ping revealed the assembly process of the mitochondrial outer membrane (TOM) translocase complex and clarified the molecular mechanism of the mitochondrial sorting assembly machine (SAM) assisting in the assembly and release of this complex .
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The relationship between chromosomal instability and senescence in Drosophila
Time of Update: 2021-09-19
Milan concluded: “The more we understand the biology of tissues affected by chromosomal instability and the molecular mechanisms of cell behavior that produce malignant tumors, the more we design effective treatments and reduce the chances of human cancer growth and malignancy.
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Targeting CD4 legendary biological CAR-T therapy starts clinical trials in the United States
Time of Update: 2021-09-19
On September 13, 2021, Legend Biotech announced that based on the IND application approved by the US FDA, it will start a phase 1 clinical trial of the cell therapy LB1901 under investigation for the treatment of relapsed/refractory peripheral T cell lymph in adults Tumor (PTCL), or skin T-cell lymphoma (CTCL) .
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Chinese scholar NSMB published a paper: Molecular mechanism of selective recognition of kinin and activation of bradykinin receptor
Time of Update: 2021-09-19
On September 9, 2021, Jiang Yi/Xu Huaqiang's team from Shanghai Institute of Materia Medica, Chinese Academy of Sciences and Wang Mingwei's team published a study titled "Molecular basis for kinin selectivity and activation of the human bradykinin receptors" on Nature Structural & Molecular Biology .
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Nature Genetics presents new insights into breast cancer "ecotype"
Time of Update: 2021-09-19
A team led by the Gavin Institute of Medical Research has revealed a new method that can classify breast cancer subtypes based on cell characteristics, which may help to personalize the treatment of patients .
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Why did the HIV "controller" finally fall?
Time of Update: 2021-09-19
In a successful immune response, cytotoxic T cells recognize small pieces of HIV called antigens found on the surface of infected cells .
Ragon member and co-author Gaurav Gaiha, MD, has previously shown that in controllers, cytotoxic T cells usually recognize HIV antigens that are unlikely to mutate .
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Xinrui teamed up to develop antisense oligonucleotide anti-cancer therapy targeting non-coding RNA
Time of Update: 2021-09-19
On September 9, Flamingo Therapeutics announced an agreement with Ionis Pharmaceuticals to jointly develop RNA targeted therapies to treat various forms of cancer .
Retrieved September 9, 2021, from https:// ionis-pharmaceuticals-to-develop-rna-targeted-therapies-for-oncology-301372060.
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Vampires who don't suck blood: New "Vampire fish" found on Amazon for the first time
Time of Update: 2021-09-19
Because of these observations, the research team recently published the first record of a parasitic catfish attached to the surface of an Amazon spiny catfish in an article published in the open-access academic journal "Acta Ichthyology" .
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Breaking the blood-brain barrier is at least one of the causes of death in cancer animals
Time of Update: 2021-09-19
This work " shows that (breaking) the blood-brain barrier is at least one of the causes of death in cancer animals, " said Wu-Min Deng, who studies fruit fly tumors at Tulane University School of Medicine.
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CRISPR-like gene cutting enzymes found in microorganisms
Time of Update: 2021-09-19
Ultra-precise CRISPR tools enhanced by enzyme engineering Zhang Feng, the lead author of the study and a molecular biologist at the Massachusetts Institute of Technology in Cambridge, said that the discovery of other RNA-targeting enzymes that can cut DNA may provide further tools for genome editing .
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Scientists have simulated how coronaviruses attach to human cells
Time of Update: 2021-09-19
Patrick Rynkiewicz, who led this research '20 (Bioinformatics and Computational Biology),' 21 MS (Bioinformatics) said: "We use complex computer simulations in the field of molecular dynamics to compare-coronavirus proteins and host cells "This is the interaction between the viral spike protein (called the receptor binding domain) and the human host cell receptor (called ACE2) .
