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Competing for the dual anti-race track, Kang Fang took the lead in starting the race. There are 67 domestic projects. Who is the hottest partner of PD-1?
Time of Update: 2021-09-20
The drug launched its first clinical trial in 2019, and the fastest progress is currently a phase Ib/III clinical trial launched in November 2020, evaluating IBI318 in combination with paclitaxel for small cell lung cancer patients who have failed standard first-line and above chemotherapy .
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Science Sub-Journal: A new way to understand protein dynamics
Time of Update: 2021-09-20
Cellular processes are regulated by the balance between different protein shapes, which give these molecules active or inactive functions .
Modesto Orozco, have developed a new computational program that can discover and quantify the shape of functional proteins, thereby revealing the molecular details of cellular processes .
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CRISPR/Cas gene editing system adds new members, Shanghai University of Science and Technology team breaks smallest record
Time of Update: 2021-09-20
This week, following the publication of the small Cas13 gene editing system by the team of well-known scholar Professor Zhang Feng, three more small CRISPR/Cas research "groups" from China, South Korea, and the United States went online, frequently rewriting the "minimum" records .
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A retrospective study found that for a common gynecological disease, hysterectomy can be avoided
Time of Update: 2021-09-20
According to research results published in the Journal of the American Medical Association Network, the syndrome is considered a common uterine disease that is usually not diagnosed until it leads to a hysterectomy, although surgery may be preventable for some women .
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Nature Sub-Journal: Genes that control the severity of colon cancer
Time of Update: 2021-09-20
Picture: Majid Kazemian and a group of scientists discovered that the TCF-1 gene plays a key role in controlling TReg cells and affects the severity of colon cancer .
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Potential genes that affect the severity of brain development
Time of Update: 2021-09-20
"The researchers conducted further studies and found that in the white LRP2 mutant and the wild type of the strain, certain genes, including ULK4 and PTTG1, were significantly up-regulated compared with black 6 mice .
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Coveli Institute Dong Subo was invited to publish a review of exoplanet statistical research in ARA&A
Time of Update: 2021-09-20
These massive discoveries have led to a major trend in the frontier research on exoplanets, which is to use large-sample observation data to systematically study the statistical properties of the distribution of planets and their host stars, and then to deeply understand the physical mechanism and environment of planet formation and evolution .
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Nature Biotechnology: Wireless recording of human brain activity in normal life activities
Time of Update: 2021-09-20
Research funded by the NIH BRAIN initiative opens the door to link deep brain activity and behaviorResearchers are now able to directly wirelessly record the brain activity of patients with Parkinson's disease, and then use this information to adjust the stimulation of implanted devices .
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Potential obesity risk indicators found in sleep
Time of Update: 2021-09-20
The research team measured the respiratory quotient throughout the night and found that despite the same age, BMI, and fat mass, people with inflexible metabolism burn more carbohydrates and less fat than people with flexible metabolism .
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Tevarisperidone sustained-release suspension for the treatment of schizophrenia enters review in the United States
Time of Update: 2021-09-20
Teva Pharmaceuticals (Teva) and MedinCell recently announced that the US Food and Drug Administration (FDA) has accepted TV-46000/mdc-IRM (risperidone sustained-release injection suspension, for subcutaneous injection) for the treatment of schizophrenia New Drug Application (NDA) .
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A new gene delivery vector can make gene therapy of muscle diseases safer and more effective
Time of Update: 2021-09-20
The team showed that due to this increase in efficiency, MyoAAV can deliver therapeutic genes at doses 100 to 250 times lower than other viral vectors used in other studies and trials, potentially reducing the risk of liver damage and other serious side effects .
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NICE recommends Novartis Rydapt to treat systemic mastocytosis
Time of Update: 2021-09-20
In terms of competitors, Ayvakit (avapritinib) developed by Blueprint was approved by the FDA in June this year to treat adult patients with advanced systemic mastocytosis (SM), including aggressive SM, SM with related blood tumors, and mast cell leukemia .
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Sticky white blood cells deform rapidly when threatened, becoming very stiff and sticky
Time of Update: 2021-09-20
The research team observed three types of white blood cells and found that in all cases, “the hardness and viscosity of the cells began to change within a few seconds of contact with the beads and increased to 10 times within a few minutes .
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Three Stanford scholars receive US$31 million to carry out stem cell clinical trials
Time of Update: 2021-09-20
jpg"/>            Three medical researchers from Stanford University received a total of nearly $31 million in funding from the California Institute of Regenerative Medicine for the first human trials of stem cells to treat stroke, heart failure, and a brain tumor and spinal cord tumor .
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New anti-cancer tactics!
Time of Update: 2021-09-20
As one of the current anti-cancer therapies with full potential, chimeric antigen receptor T cell (CAR-T) therapy has achieved optimistic results in the treatment of hematological tumors.
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Animal experiments cause liver cancer!
Time of Update: 2021-09-20
S. Food and Drug Administration (FDA) has suspended the Phearless Phase 1/2 clinical trial of the gene therapy BMN307 .
BMN307, a phenylalanine hydroxylase (PAH) gene therapy based on adeno-associated virus 5 (AAV5), is being evaluated in the Phearless study for the treatment of adult patients with phenylketonuria (PKU) .
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"Neuroscience Bulletin" published research results of the Center of Excellence for Brain Intelligence on genetic variation leading to autism
Time of Update: 2021-09-20
mso-bidi-font-family:;color:black;mso-themecolor:text1;mso-font-kerning:0pt'>This work discovered an enriched genetic point mutation in the CHD7 gene intron in a Chinese family of autism , verified its function and mechanism on neurodevelopment, and provided evidence support for common mutations as the genetic cause of autism.
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Scientists have discovered genes that control the color patterns of cats
Time of Update: 2021-09-20
Through this analysis, the research team determined the expression of a gene called Dickkopf 4 (Dkk4) on the epidermis, marking the area on the fetal skin where hair follicles grow, which later produce pigment .
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The effect of COVID-19 vaccine in preventing hospitalization, emergency room and severe illness
Time of Update: 2021-09-20
Klein, MD, of the Kaiser Permanente Vaccine Research CenterManjusha Gaglani, Master of Business Administration from Baylor Scott & White Health and Texas A&M University; Eduardo Azziz-Baumgartner, MD, Master of Public Health from the COVID-19 Response Team of the Centers for Disease Control and Prevention, and Nicola P.
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PLoS Genetics Luo Shujin and Xu Xiao's group reveal the genetics and evolution of bird eye color diversity
Time of Update: 2021-09-20
On September 10, 2021, Luo Shujin's group from the School of Life Sciences, Peking University, State Key Laboratory of Protein and Plant Gene Research, Peking University-Tsinghua Life Sciences Joint Center and Zou Zhengting's group from the Institute of Zoology, Chinese Academy of Sciences published a paper on PLoS Genetics.
