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Nat Nanotechnol: construction of T lymphocyte membrane modified interferon epigenetic nanoinducer
Time of Update: 2021-10-10
After intravenous injection, OPEN actively targets and delivers ORY-1001 to tumor cells expressing PDL1 by being recognized by the ligand (PD1/PDL1), and rapidly releases ORY-1001 under the action of intracellular glutathione (GSH), which is upregulated IFN expression promotes the activation of antigen presenting cells (APCs) and antigen presentation, activates cytotoxic T lymphocytes (CTLs), increases T cell infiltration in the tumor microenvironment, and blocks the original and IFN up-regulated multiple immune checkpoint arrangements Body-mediated immune escape (Figure 1B) .
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MIT's latest article: first detection of circulating tumor cell generation rate, revealing how cancer spreads
Time of Update: 2021-10-10
Manalis said that being able to study ctc in mice can help researchers answer many unanswered questions, such as how quickly these cells are shed by tumors, how long they survive in the circulation, and how effectively they can grow new tumors .
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Drug target mechanism for various diseases including COVID-19
Time of Update: 2021-10-10
McGill University professor Stéphane Laporte and other international research teams have discovered the working mechanism of potential drug targets for the treatment of cancer, rheumatoid arthritis, COVID-19 and other diseases .
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Use the power of stem cells to create cartilage tissue
Time of Update: 2021-10-10
Researchers at the University of Southampton have invented a new method to generate human cartilage tissue from stem cells .
1038 / s41598-021-97934-9A scaffold-free approach to cartilage tissue generation using human embryonic stem cells
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The Institute of Zoology reveals the important role of innovation in predation behavior in the success of alien bird invasions
Time of Update: 2021-10-10
To this end, the Animal Invasion Ecology Research Group and the Bird Behavior, Function and Evolution Research Group of the Institute of Zoology, Chinese Academy of Sciences have cooperated with 9,899 successful colonization events and 2,370 failures of 247 exotic birds in 199 countries or regions around the world.
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Reshape the whole brain!
Time of Update: 2021-10-10
The research published in Nature Communications highlights the development of HySyn, a system that uses neuropeptides from Hydra, a small freshwater organism, to reconnect neural circuits .
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Technical Serial No. 3: Application of Cre-loxP site-specific recombination system in the study of conditioned target gene function in mice
Time of Update: 2021-10-10
The establishment of the Cre-loxP site-specific recombination system (Cre-loxP recombination system for short) provides an effective tool for perfecting the construction of gene-edited mouse models and further researching the function of conditional target genes .
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iScience: Plant compounds can protect bees from deadly viruses
Time of Update: 2021-10-10
The research team discovered that sodium butyrate (NaB) is a compound found in many plants and is known to increase the expression of a variety of genes in animals, including those involved in immune response and learning .
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In vivo gene editing for treatment of congenital blindness Editas announces results of first human trial
Time of Update: 2021-10-10
Today, Editas Medicine announced the preliminary data of its in vivo gene editing therapy EDIT-101, a phase 1/2 clinical trial for the treatment of Leber congenital amaurosis 10 (LCA10) .
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How sepsis is not fatal
Time of Update: 2021-10-10
"These biomarkers were found to have unique changes in the blood of patients with sepsis within 6 hours and affect specific cellular pathways in specific immune cells," said Nair, associate professor of biomedical sciences, who was published in " Co-leader of the research in the Journal of Leukocyte Biology .
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"The Lancet Psychiatry" published online the latest research by Professor Huang Yueqin's team from Peking University Sixth Hospital
Time of Update: 2021-10-10
9" >" The Lancet Psychiatry " published on September 21, 2021, "Study on the Epidemiology of the Prevalence of Depressive Disorders and Utilization of Health Services in China" led by Professor Huang Yueqin from Peking University Sixth Hospital .
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"PNAS" sun exposure/vitamin D guidelines may need to be revised
Time of Update: 2021-10-10
Thomas Center for Biomedical Research of the National Institutes of Health, conducted a study to test the optimal ultraviolet radiation wavelength for human skin to produce vitamin D under the sun .
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Hippocampus: Memory is just telling stories
Time of Update: 2021-10-10
Cohn-Sheehy and his colleagues in the Dynamic Memory Laboratory of Professor Charan Ranganath of the Neuroscience Center used functional MRI to image the hippocampus of volunteers as they were learning and recalling a series of short stories .
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The ultimate solution to fight the new coronavirus: find small molecule drugs that target the non-mutated parts of the virus
Time of Update: 2021-10-10
"Singh explained that although the COVID-19 vaccine is effective, another possible tool to deal with the pandemic may be the development of antiviral drugs that target specific areas of the virus that remain unchanged due to mutations .
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Mount Sinai Hospital demonstrates a new and effective treatment for childhood leukemia
Time of Update: 2021-10-10
Aneel Aggarwal, professor of pharmacology and oncology at the Tisch Cancer Institute in Mount Sinai, and others have discovered MS67, a new, efficient and selective WDR5 small molecule degradation The agent, by using patient cancer cells in a mouse model, effectively inhibits the growth of such acute myeloid leukemia cells derived from patients in vitro and in vivo .
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Nature Methods captures the complexity of brain activity with unprecedented resolution
Time of Update: 2021-10-10
"To understand the nature of the brain's tightly connected network, it is necessary to develop new imaging techniques that can capture the activity of neurons in a wide range of brain regions at high speed and single-cell resolution," said Rockefeller's Alipasha Vaziri .
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Cell Journal: Improving the fidelity of protein synthesis can prolong life
Time of Update: 2021-10-10
Mutations in the ribosome decoding center RPS23 improve translation accuracy in Drosophila Subsequently, the research team explored the physiological consequences of this mutation in yeast, worms and flies .
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The first! FDA approves innovative treatments for liver disease in children
Time of Update: 2021-10-10
Mirum Pharmaceuticals announced today that the US FDA has approved Livmarli (maralixibat) for the treatment of cholestatic pruritus in children with Alagille syndrome (ALGS) over 1 year old .
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Single-base editing technology for chronic hepatitis B virus infection shows functional healing potential
Time of Update: 2021-10-10
Recently, Beam Therapeutics announced that its preclinical research results show that its cytosine base editor (CBE) in an in vitro model reduces the expression of hepatitis B virus surface antigen (HBsAg) and prevents the level of hepatitis B virus from rebounding after antiviral drugs are stopped.
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Gong Jiming’s research team found that nitrate transporters mediate iron redistribution in plants (2021-09-20)
Time of Update: 2021-10-10
Further research found that these two genes both regulate low-affinity nitrate transport, and also significantly affect the nitrate distribution in plants, but the accumulation of nitrate and iron does not affect each other, indicating that NPF5.
