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Organic asymmetric catalysis won the 2021 Nobel Prize in Chemistry
Time of Update: 2021-10-22
Unlike the earliest chirality source problem on earth, asymmetric synthesis because pure enantiomers already exist in nature, so it only needs to be able to transfer these existing chiral information to the product through a chemical reaction .
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When nerve cells are "amazingly" regenerating
Time of Update: 2021-10-22
Therefore, this research team used cell lineage tracing to repeat and test the claims of "astrocytes transdifferentiation into neurons in situ" reported in previous experiments .
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Wonderful genome: Coral symbiont has a unique genome
Time of Update: 2021-10-22
According to a new study, the genomes of single-celled plankton called dinoflagellate are organized in an incredibly strange and unusual way .
The research team used a technology called Hi-C to detect interactions in the chromatin of dinoflagellate, which is a combination of DNA and protein that make up the chromosome .
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Genetic analysis reveals differences in mate selection between wild coho salmon and hatched coho salmon
Time of Update: 2021-10-22
A new study on the genetic profiles of wild coho salmon and hatched coho salmon shows that there are important differences in how the two species of fish form mating pairs .
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China Medical University: Protein Processing Disorders in Parkinson's Disease
Time of Update: 2021-10-22
China Medical Zhan Xiao ni team published an article in Aging "proteomics characterized in dopaminergic neurons secrete granules showed Parkinson's disease chromogranin / secretory granules mediated impaired protein processing" .
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Boston University develops breast cancer prediction tool for black women
Time of Update: 2021-10-22
Now, researchers at the Boston University Sloan Epidemiology Center have developed and evaluated a breast cancer risk prediction model for black women in the United States for use in primary care facilities .
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Treat solid tumors!
Time of Update: 2021-10-22
▲Efficacy data of Repotrectinib in NSCLC patients with ROS1 resistance mutations (picture source: Turning Point Therapeutics official website)Elzovantinib (TPX-0022) is a powerful MET, SRC, and CSF1R inhibitor .
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PNAS｜Jiang Zhengfan's laboratory and collaborators reveal the important role of manganese ions in anti-bacterial innate immunity
Time of Update: 2021-10-22
On October 9, 2021, the Jiang Zhengfan Laboratory of the Academy of Biological Sciences and the Shen Xihui Laboratory of the Northwest University of Agriculture and Forestry and the Zhou Dongsheng Laboratory of the Military Medical College jointly published their online anti-bacterial natural immunity in the internationally renowned academic journal "PNAS" in the form of Research Article The latest achievement in the research field-T6SS translocates a micropeptide to suppress STING-mediated innate immunity by sequestering manganese .
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Guangzhou Health Institute discovers a new mechanism for regulating blood lipid homeostasis
Time of Update: 2021-10-22
Therefore, in ASGR1 knockout hepatocytes, the transcription levels of the downstream target genes PCSK9 and MTTP of SREBPs decreased, and the absorption of lipids by hepatocytes increased and the secretion decreased .
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He Zuhua's research team has made major discoveries in the mechanism of plant immunosuppression and broad-spectrum disease resistance (2021-09-30)
Time of Update: 2021-10-22
He Zuhua's research team has made major discoveries in the mechanism of plant immunosuppression and broad-spectrum disease resistanceOn September 30, 2021, the top international academic journal Cell published an online publication entitled "Ca 2+ Sensor-Mediated ROS Scavenging Suppresses Rice Immunity and Is Exploited " by the He Zuhua research team of the State Key Laboratory of Plant Molecular Genetics and researchers at home and abroad.
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Microvesicles are feasible for treating inflammatory diseases such as multiple sclerosis
Time of Update: 2021-10-22
Researchers at the Karolinska Institute used biomolecular technology to coat the outer membrane of EVs with therapeutic proteins, more precisely, receptors that bind to inflammatory substances TNF-α and interleukin 6 (IL 6) .
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Update: Mannose, a biomarker of severe COVID-19
Time of Update: 2021-10-22
Researchers at the Karolinska Institute have identified some metabolic processes that SARS-CoV-2 uses to attack lung tissue .
metabolic pathwayResearchers at the Karolinska Institute have now examined which parts of the cell’s energy supply are particularly important for SARS-CoV-2 and how they affect the severity of the disease .
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Multi-stage superimposed numerical simulation results reveal the sedimentary evolution characteristics of the continental margin basins in the South China Sea
Time of Update: 2021-10-22
The rifting period is the main period for the formation of sags in the basin, and it is also a period of active tectonic subsidence; starting from the deposition of the Zhuhai Formation, the Pearl River Mouth Basin entered the post-cracking thermal subsidence stage; after the Miocene, the northern continental margin of the South China Sea entered To the activation period of the post-fracture structure , namely the Dongsha movement .
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Nature Medicine: Single-cell analysis to determine somatic genetic events in childhood blood diseases
Time of Update: 2021-10-22
Jude Children’s Research Hospital, includes scholars from dozens of institutions, through the European Working Group of MDS in Childhood, using single-cell DNA analysis to explore the somatic genetic rescue (SGR) of children with MDS Phenomenon .
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Neural repair with stem cells
Time of Update: 2021-10-22
In an innovative method for guiding nerve repair shared in the journal npj regenerative medicine, the University of Pennsylvania team induced the growth of Schwann-like cells in human gingival-derived mesenchymal stem cells (GMSCs), which are pre-regenerative cells of the peripheral nervous system.
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Using Clostridium aerosols to transform one-carbon gas to efficiently synthesize medium and long-chain chemicals (2021-09-22)
Time of Update: 2021-10-22
The research achieved the simultaneous and efficient synthesis of isopropanol, ethanol and 3-hydroxybutanol by using syngas rich in CO 2 /CO through the combined metabolic engineering of the autotrophic bacteria Clostridium ljungdahlii ( Clostridium ljungdahlii ) Important products such as acid have demonstrated the good application potential of Clostridium aerosols in the bioconversion of industrial carbon-containing gas to produce high-value long-carbon chain compounds .
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The cells that spread the heartbeat have the potential to regenerate
Time of Update: 2021-10-22
A new study conducted by researchers at the University of Texas Southwestern (UT Southwestern) in mice shows that special cells used to conduct electrical current to keep the heart beating have a previously unrecognized To the regeneration capacity .
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The discovery of BRD4 protein function marks a key step in the treatment of complex congenital diseases and cancer
Time of Update: 2021-10-22
Since the way DNA is folded is essential for gene regulation, this research not only has implications for a series of genetic diseases including heart defects, cleft palate, microcephaly, and intellectual disability, but will also better guide BRD4 targeting Drug development, some of which are undergoing clinical trials, as promising interventions for the treatment of cancer and heart disease .
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Chinese scholars and overseas collaborators have made progress in the search for interstellar life molecules
Time of Update: 2021-10-22
Figure 1 Left: The image of the center of the Milky Way galaxy observed by the SPITZER and VLA telescopes . The white circle shows the location of the giant molecular cloud Sgr B2 . I
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Can artificial intelligence really replace the human brain?
Time of Update: 2021-10-22
The first author Nicolas Perez, a doctoral student in the Department of Electrical and Electronic Engineering at Imperial College London, said: “The brain needs efficient energy while still being able to solve complex tasks outstandingly .
They began to study whether simulating the brain by changing the properties of neural network cells can promote artificial intelligence learning .
