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Fred Hutch develops next-generation CAR-T cell therapy with greatly enhanced anti-tumor activity
Time of Update: 2021-10-23
Source: Science SignalingIn a mouse model of breast cancer with low ROR1 expression, the researchers found that traditional CAR-T cells did not show anti-tumor effects .
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There is a kind of cold called Grandma thinks you are cold. Research has revealed the reason why the older you are, the less resistant you are to freezing.
Time of Update: 2021-10-23
As adipose tissue loses ILC2, the ability of old mice to burn fat and restore body temperature under cold conditions decreases, leading to an increase in cold-induced lethality .
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Zymo's EZ DNA kit received the CE mark
Time of Update: 2021-10-23
The EZ DNA Methylation-Lightning Kit uses ready-to-use conversion reagents, which simplifies the workflow and can be completed in just over an hour .
“The kit integrates A large number of manual intensive steps required for accurate and complete DNA bisulfite conversion make the originally cumbersome workflow easy to use and ensure consistency .
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Hengrui Medicine's 1.1 category new drug pyrrotinib new indication listing application is planned to be included in priority review
Time of Update: 2021-10-23
The indication for pyrrotinib's application for marketing is "combined with trastuzumab and docetaxel, suitable for the treatment of epidermal growth factor receptor 2 (HER2) positive early or locally advanced breast cancer neoadjuvant therapy" .
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Science explains the white matter of the brain
Time of Update: 2021-10-22
However, the Hebrew University research team was the first to use Nissl-stained brain slices to reveal fiber pathways in the white matter .
Researchers realized that by using simple computational tools in the field of image processing, they could use the pattern of cell organization to reveal the structure of white matter .
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Can the intestinal flora promote cancer growth?
Time of Update: 2021-10-22
In mice with drug-resistant prostate cancer, some common bacteria were also observed to synthesize more androgens .
And if the intestinal flora of mice that have developed drug resistance are transplanted into mice with low androgen levels, it will also promote the tumor growth of the latter .
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Zhao Qing's research group has made important progress in the study of methoxyflavonoid metabolism in Scutellaria baicalensis Georgi
Time of Update: 2021-10-22
On September 7, 2021, Plant Biotechnology Journal published an online publication titled "Two types of O-methyltransferase are involved in biosynthesis of anticancer methoxylated 4′-deoxyflavones in Scutellaria baicalensis Georgi" by Zhao Qing's research group from the Center for Excellence in Molecular Plant Science, Chinese Academy of Sciences .
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Hidden Problem-Orphans in the U.S. Coronavirus-19 Pandemic
Time of Update: 2021-10-22
The authors of the study estimate that 120,630 children in the United States have lost their primary caregivers (parents or grandparents who provide housing, basic needs and care) due to covid-19-related deaths .
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This color-blind zebrafish tells you how color vision evolved
Time of Update: 2021-10-22
In this recent study, researchers figured out how different foxq2 activities help zebrafish distinguish between blue and green .
The retina of zebrafish lacking normal foxq2 gene expression has no cone cells that are sensitive to blue light .
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Toxic fatty acids may become a new target for the treatment of neurodegenerative diseases
Time of Update: 2021-10-22
"Our findings indicate that the toxic fatty acids produced by astrocytes play an important role in brain cell death, providing a promising new target for treatment, and even preventing, many neurodegenerative diseases," said Shane Liddelow , PhD, who is the second author of the article and the corresponding researcher's paper published in the book "Nature" .
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Potential "first-in-class" targeted protein degradation agents enter the clinic
Time of Update: 2021-10-22
On October 6, 2021, Dialectic Therapeutics announced that the first-generation compound DT2216, constructed based on its proprietary new anti-apoptotic protein targeted degradation technology (APTaD), has completed the first patient administration in a phase 1 clinical trial.
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"Cell Stem Cell" human or non-human? The answer lies in junk DNA
Time of Update: 2021-10-22
In a new study, stem cell researchers at Lund University examined what makes the brains of humans and chimpanzees different in our DNA-they have found the answer .
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PNAS: Peking University researchers reveal the important role of manganese ions in anti-bacterial natural immunity
Time of Update: 2021-10-22
On October 9, 2021, the Jiang Zhengfan Laboratory of the School of Life Sciences of Peking University and the Shen Xihui Laboratory of Northwest Agriculture and Forestry University and the Zhou Dongsheng Laboratory of the Military Medical College jointly published their research on antibacterial innate immunity in the internationally renowned academic journal PNAS in the form of Research Article The latest achievement in the field- T6SS translocates a micropeptide to suppress STING-mediated innate immunity by sequestering manganese .
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2021 Nobel Prize winner paper: How does the pain receptor TRPV1 perceive various natural stimuli?
Time of Update: 2021-10-22
In this study, under the conditions of applying different natural stimuli and simulating different physiological environments, with the help of single-particle cryo-electron microscopy, a series of intermediate state conformations and activation mechanisms of the capsaicin receptor TRPV1 were analyzed .
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Tong Xiaoping's research team at Nature Communications School of Basic Medicine leads the reveal of NG2 glial cells...
Time of Update: 2021-10-22
When NG2 glial cells in the hippocampus are actively activated, the inhibitory synaptic regulation mechanism of interneurons can be enhanced to eventually cause the excitatory-inhibitory imbalance of local neural microcircuits, and induce anxiety-like behaviors in mice, suggesting NG2 Glial cells are closely related to the occurrence and development of anxiety-related diseases .
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Benefit more cancer patients. This method allows the immune cells to be fully fired.
Time of Update: 2021-10-22
For example, only about 25% of patients with non-small cell lung cancer can respond optimistically to ICI .
In a patient with an excellent response to ICI, the T cells in his body that respond to cancer proteins have reprogrammed their transcriptomes into complete tumor killer cells .
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Do you think the census is difficult?
Time of Update: 2021-10-22
CSHL professor Anthony Zador's laboratory developed MAPseq to describe how different brain cells connect and interact .
He and his laboratory developed qBrain, a method that combines brain imaging technology to map the cells and connections in the primary motor cortex of mice in three dimensions .
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A study on skull growth and tooth growth shows that time is everything
Time of Update: 2021-10-22
"Glovaka and paleoanthropologist Gary Schwartz published their research this week and provided the first clear answer-a researcher at the Institute of Human Origins, a researcher at the School of Human Evolution and Social Change It is the coordination between facial growth and chewing muscles that determines when and where the adult molars appear .
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Gut Wars: How the Human Microbiota Fights Cholera Bacteria
Time of Update: 2021-10-22
Studies have shown that intestinal pathogens need to interact with bacteria in the gut microbiota-ranging from competition for nutrients to full-scale bacterial warfare in order to gain a foothold in this environment .
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Odor test to screen for early pancreatic cancer
Time of Update: 2021-10-22
Measure the chemotactic index of 11 patients with early pancreatic duct adenocarcinoma and 17 healthy volunteers Oncotarget published a report "Scent test using Caenorhabditis elegans to screen for early-stage pancreatic cancer".
