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Abandoning stereotypes, studies have found that men are more injured after breaking up
Time of Update: 2021-11-12
At the same time, these findings also show that it is not embarrassing to ask for help, because it shows how common interpersonal problems are, and that men and women are equally likely to seek help .
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One drug has the potential to curb multiple cancers
Time of Update: 2021-11-12
Westover’s laboratory has collaborated with the Dana-Farber Cancer Institute to develop a drug that binds to specific RAS mutants, the glycine at position 12 in the RAS mutant The amino acid is converted to cysteine, the so-called KRAS G12C .
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How does a protein mutation of the tomato virus ToBRFV break through the resistance of tomatoes to tobacco viruses, a serious threat to the global tomato industry?
Time of Update: 2021-11-12
The main reason for the global ToBRFV outbreak is that this new virus overcomes all known tobacco virus resistance in tomatoes, including the resistance conferred by the gene Tm-2 2 , which has always had stable resistance to these viruses .
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Cambridge University "antivirus" air filtration system-innovative nanomaterials can eliminate viruses, including coronaviruses
Time of Update: 2021-11-12
The ultra-thin carbon nanotube conductive film, a new type of conductive filter film, is heated to a temperature above 100°C through resistance, so that viruses (including β-coronavirus) lose their activity within a few seconds, thereby achieving virus filtration and disinfection through hot flash .
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An important breakthrough in "Science": Directly read protein sequences with nanopore technology!
Time of Update: 2021-11-12
Today, a top academic journal published an important paper online-for the first time scientists have used nanopore technology to directly read protein sequences with a single amino acid resolution.
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A new solid tumor targeting model for bicyclic peptide coupled immunotherapy enters the clinic
Time of Update: 2021-11-12
Today, Bicycle Therapeutics announced that its tumor-targeted immune cell agonist BT7480, designed based on bicyclic peptides, has completed its first patient administration in a phase 1/2 clinical trial .
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eLife: Researchers have successfully identified a protein in the coronavirus that can destroy blood vessels
Time of Update: 2021-11-12
Now, for the first time, a team of experts led by Tel Aviv University has been able to identify five of the 29 proteins that make up this blood vessel-damaging virus .
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Mount Sinai researchers have developed a bank of induced pluripotent stem cells from healthy people
Time of Update: 2021-11-11
Scientists at Mount Sinai have created a good library of human induced pluripotent stem cells (hiPSC) for clinically healthy humans, which can be used as a valuable resource in vitro for normal control human development, genotype-phenotype association research, many disease models And drug response assessment .
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Ibrutinib can improve the survival of young patients with diffuse large b-cell lymphoma
Time of Update: 2021-11-11
Figure: The addition of ibrutinib to R-CHOP chemotherapy improves the overall survival of trial participants 60 years of age and younger with MCD or N1 subtype non-gcb diffuse large B-cell lymphomaSource: National Institutes of Health (NCI)New evidence shows that adding targeted therapy ibrutinib (Imbruvica) to standard chemotherapy regimens can improve the survival time of some young patients with diffuse large b-cell lymphoma (DLBCL) .
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PNAS: By blocking the Bach1 protein, the degeneration of brain cells in Parkinson's disease patients is slowed down
Time of Update: 2021-11-11
To confirm this, the researchers consumed Bach1 in a mouse model of PD and showed that dopamine-producing neurons are protected by some destructive stress pathways .
Another key question is the benefits of modulating this pathway in chronic models of Parkinson's disease, other cell types in the brain, and potentially other dementias .
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Use stem cells to quickly mass produce any cell type in the human body
Time of Update: 2021-11-11
bio are glutamatergic neurons and skeletal muscle cells generated by reprogramming iPSCs using opti-ox technology .
The company pointed out that this technology can precisely control the expression of specific transcription factor combinations, thereby determining the cell types differentiated by human iPSCs.
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Nature: Sponge cells suggest the origin of the nervous system
Time of Update: 2021-11-11
Kathy Dunn, an evolutionary biologist at Yale University in New Haven, Connecticut, who studies marine invertebrates, said these findings help understand how animals’ nervous systems evolve .
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Science good news: RNA drugs for patients with rare genetic diseases are coming out soon
Time of Update: 2021-11-11
This drug : The story of milasen (named after the girl Mila) has inspired people to use short-stranded RNA (called antisense oligonucleotides (ASOs)) for more personalized treatments that can overcome genetic defects .
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The latest paper from Southern Medical University discovers new neural circuits and molecular mechanisms for anxiety and fear emotions
Time of Update: 2021-11-11
On October 26, 2021, Tianming Gao's team from our school published a research paper entitled "PV Network Plasticity Mediated by Neuregulin1-ErbB4 Signalling Controls Fear Extinction" in Molecular Psychiatry (impact factor 15.
This study revealed the local molecular loop mechanism of mPFC-mediated "top-down" regulation of fear memory fading .
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How to correctly select active genes
Time of Update: 2021-11-11
The collaboration of scientists at the University of Barna-Champaign has now made a new discovery in the formation of a transcription factory: it is similar to the condensation of liquids .
The combination of observation and simulation makes the condensation process reproducible and explains how living cells can quickly and reliably build transcription factories .
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Researcher Zhang Lin from the School of Physics and collaborators have made important progress in the research on the PM2.5 health effects of global agricultural ammonia nitrogen
Time of Update: 2021-11-11
9" >Researcher Zhang Lin from the Department of Atmospheric and Oceanic Sciences, School of Physics, Peking University, researcher Gu Baojing from Zhejiang University, and Professor Mark Sutton from the British Eco-Hydrology Center have made important progress in the study of the atmospheric environment and health effects of global nitrogen emissions .
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Chinese scholars and overseas scholars have made progress in the prevention and treatment of drug-induced liver injury
Time of Update: 2021-11-11
This study reveals that the dual functions of MG53's membrane separation signal and cytosolic effect effectively maintain the integrity of liver cells in drug-induced liver injury, suggesting that MG53, as a myocytokine, may provide new ideas and new ideas for the prevention and treatment of drug-induced liver injury.
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Xue Yongbiao's research team collaborated to reveal the highly dynamic evolutionary mechanism of the origin, loss and regain of self-incompatibility in angiosperms
Time of Update: 2021-11-11
Among them, the type 1 S site often contains one S- nuclease and multiple SLFs , which respectively encode female and male self-incompatibility determinants .
Figure: The origin, loss and regain mechanism of self-incompatibility in flowering plants
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Multiple sclerosis drugs improve memory in Alzheimer's disease model mice
Time of Update: 2021-11-11
M. Kerry O'Banion, MD, professor of neuroscience and senior author of the study, said: “This study expands our information about the potential use of Glatiramer acetate in Alzheimer’s disease .
Evaluating Effects of Glatiramer Acetate Treatment on Amyloid Deposition and Tau Phosphorylation in the 3xTg Mouse Model of Alzheimer’s Disease .
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"Science Advances" Live Skin DNA Transfection Platform: Similar to "Cupping" of Traditional Chinese Medicine
Time of Update: 2021-11-11
This method provides an easy-to-use, cost-effective and highly scalable platform for the laboratory transfection requirements and clinical applications of nucleic acid therapy and vaccines .
