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"Cell Metabolism" A New Way to Regulate Blood Sugar Levels Independently of Insulin
Time of Update: 2022-01-07
Like insulin, FGF1 controls blood sugar by inhibiting lipolysis, but the two hormones work in different ways .
These similarities led the research team to doubt whether FGF1 and insulin use the same signaling (communication) pathway to regulate blood sugar.
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"Cell" Yeast Nuclear Pore Complex Model
Time of Update: 2022-01-07
Boston University researchers have developed a yeast nuclear pore complex modelThe research results provide an in-depth perspective for studying the communication between the nucleus and the cell bodyNuclear pore complexes (NPCs) are a large number of multi-protein complexes that serve as channels for molecules to enter and exit the nucleus .
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A protein facility user reveals the molecular mechanism of the ACE2 receptor inducing the dynamic conformational transition of the new coronavirus spike protein
Time of Update: 2022-01-07
This study uses cryo-electron microscopy combined with biochemical analysis to analyze the high-resolution cryo-electron microscopy structure of the new coronavirus spike protein trimer binding receptor ACE2, revealing the molecular mechanism of ACE2 inducing the dynamic conformational transition of the spike protein, and provides a deeper understanding of the new coronavirus The mechanism of infecting cells provides a structural basis and provides important information for the design and optimization of vaccines and therapeutic drugs designed to block receptor binding .
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Studies have found that the microbial diversity in the giblets of wild bears that eat human food is reduced
Time of Update: 2022-01-07
"We know that the'Western' diet reduces the microbial diversity in the gut of humans, mice, and other species, which may adversely affect their health," the co-author of the study and an assistant professor of applied ecology at North Carolina State University Erin McKenney (Erin McKenney) said .
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The new Tibetan medicine research and development discipline group has made new progress in the study of free radical inhibitors of Saxifraga
Time of Update: 2022-01-07
The Tibetan Medicine New Drug Research and Development Discipline Group of the Northwest Plateau Institute of Biology, Chinese Academy of Sciences found that the components of Saxifraga have excellent free radical scavenging activity in vitro, but it is not clear about the exogenous free radical suppression contained in it.
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PNAS: How do ultramicrobacteria in the environment adapt to life in the human body
Time of Update: 2022-01-07
In order to verify this hypothesis, scientists developed a model system to experimentally study the function and influence of ADS on TM7x and its host bacteria .
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Genome editing on blood vessel wall cells for the first time
Time of Update: 2022-01-07
Lurie Children’s Hospital in Chicago has developed a unique nanoparticle that can deliver genome editing technologies including CRISPR/Cas9 to endothelial cells (i.
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Cong Yao's research group reveals the allosteric and substrate recognition mechanism of the proteasome induced by the ubiquitin chain
Time of Update: 2022-01-07
This study analyzed the near-atomic resolution cryo-EM structure of a series of proteasomes in the presence of K48-Ub 4 ubiquitin chains, and for the first time captured the three-dimensional structure of the proteasome bound to K48-Ub 4 ubiquitin chains, revealing the ubiquitin chain The molecular mechanism that regulates the proteasome's recognition of ubiquitinated substrates and triggers substrate degradation provides a key structural basis for the ultimate elucidation of the mechanism of proteasome degradation of ubiquitinated substrates under physiological conditions .
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Nature: How do active DNA molecules with therapeutic potential work
Time of Update: 2022-01-07
Its purpose is to target unwanted RNA molecules in viruses, cancers or damaged nerve cells, using DNAzymes to attack and destroy them .
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A protein facility user reveals the unique composition and structure of the mammalian radiation axis head complex
Time of Update: 2022-01-07
This study is the first to analyze the high-resolution cryo-EM structure of the RS head complex, which plays a key role in the movement of higher animal cilia, and clarifies the interaction between the radiation axis and the central microtubule accessory structure, and is used to study the molecular mechanism of cilia swing It provides an important structural basis and reveals the possible causes of PCD caused by related gene mutations .
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Liu Yunquan's research group has made new progress in the generation and control of high-order harmonics with lateral angular momentum
Time of Update: 2022-01-07
9" >Professor Liu Yunquan’s group from Peking University School of Physics and State Key Laboratory of Artificial Microstructures and Mesoscopic Physics proposed to obtain controllable lateral orbital angular momentum extreme ultraviolet high-order harmonics based on ultra-short high-intensity spatiotemporal optical vortex beams (Spatiotemporal Optical Vortex, STOV) The wave generation (High Harmonic Generation, HHG) method has discovered the characteristic spectral structure of the harmonics generated by the spatiotemporal vortex beam, revealing its internal physical mechanism .
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Chromosome-level genome assembly of human fungal pathogens reveals collinearity between geographically different species
Time of Update: 2022-01-07
This study provides an important resource for fungal researchers and further emphasizes the importance of chromosome-level assembly in the analysis of high-throughput data sets .
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Liu Min and Chen Ruichuan’s team published a paper in Nucleic Acids Research, revealing the molecular mechanism of P-TEFb complex "resurrection" regulating gene transcription extension
Time of Update: 2022-01-07
As early as 2008, the team revealed on Genes & Development that the calcium ion signal dissociates the transcriptionally inactive 7SK snRNP complex and releases the molecular mechanism of the core P-TEFb by dephosphorylating the Cdk9 T186 site; in 2016, the team reported on Nucleic Acids Research further revealed how the activated Brd4/P-TEFb and SEC/P-TEFb complex restarts the suspended transcription elongation process .
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Stem cells help gecko regenerate "perfect" tail
Time of Update: 2022-01-02
Thomas Lozito, the corresponding author of the research paper and assistant professor of stem cell biology and regenerative medicine at the University of Southern California, explained that the natural regenerated tail of a gecko is “just a bunch of concentric tubes composed of fat, muscle, and skin.
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Study found that RAB5A expression is a predictive biomarker of trastuzumab in breast cancer
Time of Update: 2022-01-02
The correlation between RAB5A expression and T-DM1 sensitivity was confirmed in breast cancer patients treated with trastuzumab emtansine/pertuzumab in the I-SPY2 trial (NCT01042379), but in the trastuzumab/paclitaxel control Not confirmed in the group .
RAB5A expression is a predictive biomarker for trastuzumab emtansine in breast cancer.
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Humans have accelerated the extinction of mammoths
Time of Update: 2022-01-02
"Our research shows that humans are a key and long-term driver of the decline in the number of mammoths, and they play a vital role in the time and place of their extinction," said Dami, lead author of the Institute of Environmental Studies at the University of Adelaide.
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Novo Nordisk Wegovy announced the results of a 3b clinical trial
Time of Update: 2022-01-02
The results of the STEP 5 trial showed that obese adult patients were able to lose weight and maintain weight loss during 2 years of Wegovy treatment .
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The first in China!
Time of Update: 2022-01-02
Article source: Medical Rubik's Cube InfoOn October 30, Zejing Pharmaceuticals announced that the phase III clinical trial of topical recombinant human thrombin has reached the primary endpoint of the study.
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Don't sleep well and be careful of dementia!
Time of Update: 2022-01-02
The relevant research results were published in the journal Science Translational Medicine on November 3, 2021, with the title of the paper "Restoring activity in the thalamic reticular nucleus improves sleep architecture and reduces Aβ accumulation in mice" .
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Science: Map the global distribution of eukaryotic plankton biodiversity
Time of Update: 2022-01-02
This study highlights the huge differences in the geographic structure of plankton groups, which depend on their diversity, size, and ecology, which may be related to changes in sensitivity to local environmental conditions .
