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Nature Protocols reports a metabolomics data processing method based on machine learning and parallel computing
Time of Update: 2022-01-07
Recently, the team of Professor Feng Zhu from the School of Pharmacy of Zhejiang University and the Institute of Intelligent Innovative Medicines and the Alibaba - Zhejiang University Future Digital Healthcare Joint Research Center published a research paper entitled " Optimization of metabolomic data processing using NOREVA" in " Nature Protocols " .
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How do "PNAS" dangerous genes change the neuroprotective mechanism?
Time of Update: 2022-01-07
This model allows them to observe the effects of knocking out specific genes in neurons or glial cells on lipid droplet formation and neurodegeneration with or without ROS .
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The impact of hail events on the carbon-water coupling process of Xishuangbanna rubber plantation...
Time of Update: 2022-01-07
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The Mass Spectrometry System team and Shanghai Jiaotong University collaborated to reveal a new regulation mechanism of schizophrenia through non-standard quantitative proteomics technology
Time of Update: 2022-01-07
Further in-depth bioinformatics functional analysis showed that in patients' white blood cells, oxidative stress pathways and energy metabolism pathways were significantly activated, which mediated the process of cell apoptosis and induced the occurrence of mental diseases .
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Analysis of ADC technology's patent layout strategy
Time of Update: 2022-01-07
1. 2 RC28RC28 is a VEGF/FGF dual target fusion protein used to treat eye diseases, and it is also one of the core products of Rongchang Biological .
However, as shown in Figure 2, in a patent application CN111433188A on ADC drug linker, the author found that it disclosed ADC targeting Claudin 18.
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The differential expression of CREM/ICER subtypes is related to the spontaneous control of HIV infection
Time of Update: 2022-01-07
In order to clarify the biological mechanism of resistance to HIV replication at the molecular and cellular levels, we performed RNA sequencing and identified selectivity among ECs, HIV-infected individuals receiving ART, HIV-infected individuals without ART treatment, and healthy controls.
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Chinese scholars have made new progress in biomineralization research
Time of Update: 2022-01-07
Figure 1 Diagram of the mechanism of pathological calcification mediated by extracellular DNA Figure 2 RNA/Calcium Phosphorus Precursor-Nanorobot for Rapid Repair of Bone Defects With funding from the National Natural Science Foundation of China (approval numbers: 81722015, 81870805, 81870787) and other funding, the Air Force Military Medical University Niu Lina team revealed a new mechanism of nucleic acid-mediated biomineralization and expanded its new applications .
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Candida albicans promotes the progression of oral squamous cell carcinoma in vivo and in vitro
Time of Update: 2022-01-07
Candida albicans,but notCandida diseaseBy stimulating the overexpression of matrix metalloproteinases, tumor metabolites, tumor signaling pathways and prognostic marker genes associated with metastatic events, it promotes the progression of oral squamous cell carcinoma .
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Mass spectrometry system and Cong Yao's research group cooperate to reveal the structure and activation mechanism of mammalian PA28αβ-iCP immune proteasome
Time of Update: 2022-01-07
This study analyzed the high-resolution cryo-EM structure of the mammalian PA28αβ-iCP immune proteasome for the first time, and revealed the unique molecular mechanism of the activator PA28αβ binding and activating the immune proteasome, providing a deeper understanding of the substrate degradation mechanism of the immune proteasome Structural basis .
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Amazing discovery: Alleles are different in paternal inheritance and maternal inheritance.
Time of Update: 2022-01-07
"Although the general imprinting mechanism of the mouse H19 locus has been well established, it is not clear how the expression of H19 is affected by its own methylation status," explained Assistant Professor Hitomi Matsuzaki, who was responsible for this.
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Intestinal-brain connections in autistic patients
Time of Update: 2022-01-07
Now, researchers at Harvard Medical School and the Massachusetts Institute of Technology (MIT) have discovered the missing link by studying mouse models: infections during pregnancy cause the inflammatory signaling molecule interleukin-17a (IL-17a) Increased levels will not only affect the brain development of the fetus, but also change the maternal microbiota, thereby preparing the newborn’s immune system for future inflammatory attacks .
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Protein facility users reveal the molecular mechanism of autophagy receptor protein recruitment to ULK complexes related to autophagy initiation
Time of Update: 2022-01-07
At the same time, the team further research found that the TBK1 kinase-mediated autophagy receptor protein Optineurin (involved in the selective autophagy process of mediating protein aggregates, invading pathogens, and damaged mitochondria) of the 177-position serine phosphate of the LIR motif Chemical will regulate and enhance the interaction between Optineurin LIR and FIP200 Claw .
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JAMA latest: Over 50% of Chinese adults have diabetes or are in the pre-disease stage
Time of Update: 2022-01-07
The paper pointed out that the current study is based on a large number of samples (170,287 and 173,642 subjects were included in the final analysis in 2013 and 2018), and it provides the latest statistics on the prevalence, treatment level, and risk factors of diabetes in China .
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The Zhao Shizhen team of Shanghai Jiaotong University has made important progress in the design and optimization of the optoelectronic hybrid data center network architecture
Time of Update: 2022-01-07
Recently, the Dean of the John Hopcroft Computer Science Center of the School of Electronic Information and Electrical Engineering, Shanghai Jiaotong University, hired Associate Professor Zhao Shizhen’s team to make important progress in the design and optimization of the opto-electronic hybrid data center network architecture.
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Cong Yao's research group used cryo-electron microscopy to reveal the conformational change space and subunit-specific mechanism of TRiC/CCT
Time of Update: 2022-01-07
Therefore, exploring the complete conformational change process and mechanism of TRiC driven by ATP, as well as the structural basis of the functional specificity of each subunit, is helpful to clarify the molecular mechanism of its substrate recognition and folding, and to reveal the relationship between TRiC and the above-mentioned human diseases.
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Cell recently proposed a model of the yeast nuclear pore complex
Time of Update: 2022-01-07
Researchers at Boston University School of Medicine (BUSM) used rapid descent freezing and electron microscopy, combined with computational methods, to create a comprehensive model of yeast NPC, revealing the interconnected structure of its core scaffold .
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The biomass energy team is in the genetic improvement and biochemical conversion of energy crops and energy microbes...
Time of Update: 2022-01-07
Relevant research results are "Down-regulation of OsMYB103L distinctively alters beta-1,4-glucan polymerization and cellulose microfibers assembly for enhanced biomass enzymatic saccharification in rice" and "Double integrating XYL2 into engineered Saccharomyces cerevisiae strains for consistently enhanced bioethanol production by effective xylose and hexose co-consumption of steam-exploded lignocellulose in bioenergy crops", published in the well-known international bioenergy journals Biotechnology for Biofuels and Renewable Energy .
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A small study shows that the new crown epidemic may slow down the development of babies
Time of Update: 2022-01-07
This research,Published in the Journal of Pediatrics of the American Medical AssociationToday, researchers found that 6-month-old babies during the pandemic score slightly lower in motor and social skills, as their mothers reported in a widely used developmental assessment.
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A 12-year follow-up study: The effect of chronic disease on the brain is not general, but only slightly affected by general anesthesia
Time of Update: 2022-01-07
After adjusting for age, gender, education level, smoking status, alcoholism and other factors related to the risk of cognitive decline, the researchers found that compared with people who have never undergone surgery, they have had at least one type of general anesthesia Of patients may perform worse on selective attention, executive ability, and selective attention tests .
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He Guangqiang and Jiang Chun of Shanghai Jiaotong University have made scientific research progress in the field of topological quantum optics
Time of Update: 2022-01-07
Recently, the team of He Guangqiang and Jiang Chun of the State Key Laboratory of Regional Optical Fiber Communication Network and New Optical Communication System, Department of Electronic Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiaotong University, and Jiang Chun have made progress in the field of topological quantum optics.
