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Researchers have developed nanoparticles that can target white blood cells that cause acute lung inflammation
Time of Update: 2022-01-08
This group of scientists pointed out that although there is still a long way to go in the development of a feasible treatment for ALI/ARDS that uses nanoparticles to provide treatment through neutrophils, this research represents a step forward in understanding the status and function of the immune system.
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The biochemical "switch" that controls the development of regulatory T cells found
Time of Update: 2022-01-08
The researchers discovered a biochemical process consisting of three steps in mouse T cells: first, precursor cells receive guidance signals and initiate the development of regulatory T cells; then, a table called histone acetylation The genetic mechanism acts as a switch to turn on the expression of Foxp3, just like a battery starts an engine .
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The research groups of Xiao Yunfeng and Gong Qihuang of Nano Optoelectronics Frontier Science Center have made important research progress in the field of micro-nano light field regulation
Time of Update: 2022-01-08
Words for Java 18. 9" >The group led by Professor Xiao Yunfeng and Academician Gong Qihuang from the School of Physics, Peking University, Frontier Science Center for Nano-Optics Electronics, State Ke
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F1204 and F1781 can effectively inhibit Lassa virus mini genome activity
Time of Update: 2022-01-08
Recently, the team of Xiao Gengfu and Wang Wei of Wuhan Institute of Virology, Chinese Academy of Sciences/State Key Laboratory of Virology published a report entitled " Screening and Identification of Lassa Virus Endonuclease-targeting Inhibitors from a Fragment- " in Antiviral Research (" Antiviral Research ").
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Use CRISPR technology to modify tumor cells in situ and reshape macrophages to achieve effective tumor immunotherapy
Time of Update: 2022-01-08
722 ) in the field of nanotechnology published an online publication titled " CRISPR-based in situ engineering tumor cells to reprogram macrophages for effective cancer" " Immunotherapy " (using CRISPR technology to modify tumor cells in situ to reshape macrophages to achieve effective tumor immunotherapy) research results .
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Wuhan Institute of Virology screened the entry inhibitor of the fourth-level pathogen Luyo virus
Time of Update: 2022-01-08
After multiple rounds of screening, three drugs targeting LUJV entry, trametinib, manidipine, and lercanidipine were obtained .
Manidipine and Lercanidipine are dihydropyridine calcium ion channel inhibitors and show broad-spectrum antiviral effects against New World Arenavirus .
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Mass spectrometry system cooperation has made significant progress in the study of the molecular mechanism of the new coronavirus COVID-19
Time of Update: 2022-01-07
On July 22, 2020, the National Protein Science Research (Shanghai) Facility Mass Spectrometry System Team of the Shanghai Institute for Advanced Study of the Chinese Academy of Sciences collaborated
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Chen Yong's research group reveals a new mechanism for the assembly and activity regulation of the MLL1 methyltransferase complex
Time of Update: 2022-01-07
On September 24, 2019, the international academic journal "Nucleic Acids Research" published online the latest research of the Chen Yong research group of the Chinese Academy of Sciences Molecular Ce
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Professor Yu Cao’s team published a paper in Circulation Research for the first time to reveal the effect of ischemic myocardial-derived extracellular microvesicles in inducing adipocyte dysfunction...
Time of Update: 2022-01-07
This study revealed that after MI/R in mice, sEV (Myo-sEVMI/R) secreted by damaged cardiomyocytes induced changes in the expression of ER stress-related proteins in adipocytes through the miR-23-27-24 cluster carried, and significantly inhibited APN protein.
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Will it be more difficult to treat the new crown flu?
Time of Update: 2022-01-07
The winter outbreak of influenza virus is approaching, and mankind is once again facing the dual threat of influenza virus and new coronavirus . A few days ago, the "Times of Israel" reported that a
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Smell and cancer?
Time of Update: 2022-01-07
Researchers at Massachusetts General Hospital (MGH) found that an olfactory receptor gene that helps the sense of smell may also play a role in the metastasis of breast cancer to the brain, bones and lungs .
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Dare to leave a gap in the genome
Time of Update: 2022-01-07
Although DNA sequencing has become much cheaper since the human genome was first deciphered in 2003, collecting complete genetic information is still a large part of the cost of animal and plant breeding .
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How brain cells die in prion diseases
Time of Update: 2022-01-07
The researchers also discovered a key protein complex that is responsible for guiding PrP to axons and causing aggregation associated with axon swelling .
The researchers found in their experiments that the mutant PrP produced in somatic cells is also largely encapsulated in vesicles, which move to axons along railroads called microtubules .
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How does the "king of cancer" help the early detection of pancreatic ductal adenocarcinoma?
Time of Update: 2022-01-07
Recently, the team of Professor Yin Yuxin of Peking University School of Basic Medicine and the collaborators of the Chinese Academy of Sciences and the Chinese People’s Liberation Army General Hospital applied machine learning combined with lipidomics and multi-omics techniques to comprehensively analyze the metabolic characteristics of pancreatic ductal adenocarcinoma (pancreatic cancer), and developed artificial The intelligent-assisted PDAC serum metabolism detection method achieved 86.
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Clinical trials have shown that stereotactic radiation prolongs system therapy and slows the progression of kidney cancer
Time of Update: 2022-01-07
Simmons Comprehensive Cancer Center at the University of Texas Southwest shows that despite the slow progress of drug therapy, highly focused radiotherapy for isolated metastases can Prolong the efficacy of drugs in patients with kidney cancer .
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In addition to spike protein mutations may also contribute to the emergence of more contagious mutations
Time of Update: 2022-01-07
Research by the Quantitative Biological Sciences Institute (QBI) of the University of California, San Francisco shows that among other viral proteins, mutations other than spike proteins may also help more infectious mutations to evade the immune system and spread quickly .
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What happens after changing the "sponge" of stem cell nuclei?
Time of Update: 2022-01-07
Complex mixtures, such as the inside of cells, have both spongy solid properties (elasticity) and viscous liquid properties (viscosity), giving a more complete description of how materials respond to forces .
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Zhong Yi's research group from Shanghai Institute of Immunotherapy Innovation published online research results, in order to explore high-efficiency immunity...
Time of Update: 2022-01-07
This study successfully mapped the dynamic changes of the regulatory profile of T cells from the silent state into effector cells, which not only helps to strengthen researchers' understanding of T cell biology, but also provides lasting protection for the exploration of efficient immunotherapy methods and designs The vaccine has laid the foundation for preventing the spread of large-scale infectious diseases .
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Nature Protocols reports a metabolomics data processing method based on machine learning and parallel computing
Time of Update: 2022-01-07
Recently, the team of Professor Feng Zhu from the School of Pharmacy of Zhejiang University and the Institute of Intelligent Innovative Medicines and the Alibaba - Zhejiang University Future Digital Healthcare Joint Research Center published a research paper entitled " Optimization of metabolomic data processing using NOREVA" in " Nature Protocols " .
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How do "PNAS" dangerous genes change the neuroprotective mechanism?
Time of Update: 2022-01-07
This model allows them to observe the effects of knocking out specific genes in neurons or glial cells on lipid droplet formation and neurodegeneration with or without ROS .
