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Nature: Launch of a new drug discovery tool that can screen more than 11 billion compounds
Time of Update: 2022-01-10
As a result, scientists have finally created a huge library of theoretical compounds: billions of mostly'undiscovered' and unexplored molecules, which may or may not bind to specific cellular targets; they may or may not.
Synthon-based ligand discovery in virtual libraries of over 11 billion compounds.
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Zhou Bin's group cooperates to reveal the source and formation process of myofibroblasts after heart injury
Time of Update: 2022-01-10
TRS_Editor A{font-family:;font-size:12pt;}</> On December 21, the international academic journal Circulation published the research results of the collaboration of Zhou Bin's group at the Center for Excellence in Molecular Cell Science (Institute of Biochemistry and Cell Biology) of the Chinese Academy of Sciences, Professor Sun Kun from Xinhua Hospital of Shanghai Jiaotong University, and Professor Lv Ailan of the Chinese University of Hong Kong "Seamless Genetic Recording of Transiently Activated Mesenchymal Gene Expression in Endothelial Cells During Cardiac Fibrosis" .
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Zhang Zemin's research team and collaborators reveal the mechanism of anti-PD-1 immunotherapy in lung cancer
Time of Update: 2022-01-10
Words for Java 18. 9" >On December 23, 2021, Peking University Biomedical Frontier Innovation Center (BIOPIC), School of Life Sciences, Beijing Future Gene Diagnosis Advanced Innovation Center (ICG) Z
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Japan: All people from the United States will be quarantined in designated locations for 3 days
Time of Update: 2022-01-10
529 mutant strain) (Summary)As shown in the attachment, Ecuador, Slovakia, the entire United States, Lithuania, and Russia have been newly designated as the "designated countries/regions of the Omicron strain (B.
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EMBO of Nanjing University of Science and Technology Reveals New Targets for Psoriasis Intervention
Time of Update: 2022-01-10
jpg" o:title=" "/>The molecular mechanism of SHP2 exacerbating the progression of psoriasis Nanjing University School of Life Sciences, Sun Yang team in 2021 Nian 12 Yue 22 Ri in EMBO Molecular Medicine entitled online Allosteric inhibition of SHP2 uncovers aberrant TLR7 trafficking in aggravating psoriasis long article found phosphatase SHP2 by de TLR7 phosphorylation promote their Endosomal localization intensifies the progression of psoriasis, and inhibition of SHP2 can significantly improve psoriasis-like skin inflammation in mice .
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How "photosynthetic" algae survived long periods of darkness
Time of Update: 2022-01-10
This study discovered how some single-celled algae species survived the last mass extinction, and this discovery may change our understanding of global ocean processes .
In a new study, scientists from the Bigelow Laboratory for Ocean Sciences discovered how some species of single-celled algae survived the mass extinction.
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The first model to predict the lifetime risk of heart failure
Time of Update: 2022-01-10
Now, the model will allow doctors for the first time to estimate a person’s risk of heart failure in the next 30 years based on a person’s current level of risk factors, such as body mass index, blood pressure, cholesterol, diabetes, and smoking status .
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Peng Jinrong's laboratory published a paper in NUCLEIC ACIDS RESEARCH
Time of Update: 2022-01-10
Title: Rcl1 depletion impairs 18S pre-rRNA processing at the A(1)-site and up-regulates a cohort of ribosome biogenesis genes in zebrafish ( IF=15.
542 )Authors : Zhu, Qinfang; Tao, Boxiang; Chen, Hong; Shi, Hui; Huang, Ling; Chen, Jun; Hu, Minjie; Lo, Li Jan; Peng, Jinrong* ()Source publication: NUCLEIC ACIDS RESEARCHVolume : 49 Issue : 10 Page : 5743-5759DOI: 10.
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"Cell Stem Cell" changes scientific dogma
Time of Update: 2022-01-10
It is well known that in human embryos, the initiation of transcription (embryonic genome activation) occurs at the eight-cell stage .
Now, a research team in the United Kingdom has thoroughly studied gene expression in single-cell embryos, and their findings indicate that gene expression begins at the single-cell stage of human embryos .
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Why is it healthy for them to eat sugar?
Time of Update: 2022-01-10
The results showed that people with this genetic variant suffer from sucrase-isomaltase deficiency, which means that they have a special way of metabolizing sugar in the intestine .
One group was artificially inhibited to absorb sugar, which is similar to the genetic variation found in Greenlanders .
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Child obesity is linked to mothers’ unhealthy diet during pregnancy
Time of Update: 2022-01-10
A new study led by the University of Southampton shows that supporting women to eat a healthy diet before pregnancy can reduce the risk of obesity in their children .
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Xu Shuhua’s team analyzes the genetic origin and phenotypic convergence evolution mechanism of Asian tropical natives
Time of Update: 2022-01-10
According to the population distribution rules of the early Asian ancestors, the researchers identified the gene fragments representing the components from the existing Asian tropical indigenous genomes without using any ancient DNA , and foundIt may be closely related to the adaptive evolution of human hair morphology (such as LIMS1 gene) and bone development (such as COL24A1 gene) .
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Cell: What makes mRNA vaccines effective against SARS-CoV-2
Time of Update: 2022-01-10
"The longer the T follicle helper cells provide help, the better the antibody, and the more likely you are to have a good memory response," said Philip Mudd, MD, assistant professor of emergency medicine at the University of Washington and co-corresponding author.
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Anti-aging new recruits scientists design "smart bombs" to remove old cells
Time of Update: 2022-01-10
Recently, Spanish and British researchers have collaborated to design a "smart bomb" antibody-conjugated drug (ADC), which can slow down aging by removing senescent cells from human tissues .
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Ancient DNA reveals the oldest genealogy in the world
Time of Update: 2022-01-10
Provided by the Corinium Museum, copyright belongs to the Cotswold District CouncilAn analysis of ancient DNA from one of the best-preserved Neolithic tombs in Britain revealed that most of the people buried there are descendants of five generations of a large family .
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Science: How diet-related factors affect the immune response of cancer patients
Time of Update: 2022-01-10
A new study for melanoma patients shows that dietary fiber and probiotics affect the gut bacteria and immunotherapy response of melanoma patients .
However, it is unclear whether factors such as dietary fiber intake and the use of commercial probiotics will affect the immunotherapy response of cancer patients .
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PacBio announces the winners of the 2021 SMRT Animal and Plant Funding Program
Time of Update: 2022-01-10
This year's 2021 Plant and Animal SMRT Grant will provide scientists with free PacBio sequencing to support the discovery of agricultural genomics .
After receiving funding, Zoë, Sophie and Tom plan to perform pan-genome sequencing and assembly of the apples grown in their orchards .
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Du Aifang's laboratory published a paper in INTERNATIONAL JOURNAL FOR PARASITOLOGY
Time of Update: 2022-01-10
214 )Authors : Wu, Fei ； Zhang, Hui ； Zhou, Jingru ； Wu, Jie ； Tong, Danni ； Chen, Xueqiu ； Huang, Yan ； Shi, Hengzhi ； Yang, Yi ； Ma, Guangxu ； Yao, Chaoqun ； Du, Aifang* (Du Aifang)Source publication: INTERNATIONAL JOURNAL FOR PARASITOLOGYVolume 51, Issue 12, Page 1015-1026DOI10.
ijpara.
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The communication between cells plays an important role in determining their fate
Time of Update: 2022-01-10
New findings:Adam MacLean, Assistant Professor of Quantitative and Computational Biology at the University of Southern California, Dornsif, and PhD candidate Megan Rommelfanger have found a way to better understand cells How inter-communication affects methods of hematopoietic stem cell development .
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Chinese scholars have made progress in the preparation of wafer-level van der Waals dielectric films
Time of Update: 2022-01-10
Tianyou Zhai’s team took a different approach, using the structural characteristics of the surface of inorganic molecular crystals without dangling bonds, and using a thermal evaporation method compatible with semiconductor preparation processes to realize the controllable preparation of wafer-level van der Waals dielectric films, which is a high-performance two-dimensional semiconductor device.
