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Wang Likun's team discovered a new mechanism by which tumor cell unfolded proteins respond to regulate tumor immunity
Time of Update: 2023-01-06
" 。 The study found that the activation of IRE1α/XBP1 signaling pathway in tumor cells inhibits anti-tumor immunity and promotes tumor growth by promoting the synthesis and secretion of own cholesterol.
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The collaborative research of Yu Yongfu's research group of Fudan University has made progress in the field of diabetes
Time of Update: 2023-01-06
This study demonstrates that children with diabetes have an increased risk of early onset kidney disease overall and specific types, and that preventing and treating diabetes early in childhood may significantly reduce the risk of developing kidney disease later in life.
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eLife: Gene interactions can classify intestinal tumors
Time of Update: 2023-01-06
"Gene interaction perturbation network deciphers a high-resolution taxonomy in colorectal cancer This new classification of bowel cancer will help people understand the disease and may eventually be used by doctors in precision medicine – helping them tailor the best treatment for individual patients.
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Nature: Faulty RNA handling leads to longer lifespan
Time of Update: 2023-01-06
”References: Decreased spliceosome fidelity and egl-8 intron retention inhibit mTORC1 signaling to promote longevity" by Wenming Huang, Chun Kew, Stephanie de Alcantara Fernandes, Anna Löhrke, Lynn Han, Constantinos Demetriades and Adam Antebi, 19 September 2022, Nature Aging "We found a gene called PUF60 in nematodes, which is involved in RNA splicing and regulating lifespan," said Dr. Wenming Huang, the Max Planck scientist who discovered the discovery.
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Jing Wang's research team in the School of Pharmacy developed a single-base quantitative sequencing detection method for m6A
Time of Update: 2023-01-06
The m6 A detection technology "GLORI" (Glyoxal and nitrite-mediated deamination of unmethylated adenosine) developed by Wang Jing's research group breaks through the limitations of the above technology and achieves for the first time the real meaning of highefficiency, high sensitivity, high specificity, and no preference single base m6 A site detection, andm6 The modification level of the A site is absolutely quantified.
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THE LEMIN LAB PUBLISHES PAPERS IN MICROBIOLOGY SPECTRUM
Time of Update: 2023-01-06
02479-22Published online: OCT 2022Document type: Article; Early AccessAttachment: Full text link ：Comprehensive Assessment of Subtyping Methods for Improved Surveillance of Foodborne Salmonella（IF=8.
02479-22Published online: OCT 2022Document type: Article; Early AccessAttachment: Full text link ：Comprehensive Assessment of Subtyping Methods for Improved Surveillance of Foodborne Salmonella（IF=8.
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Nature: The results of the first discovery of malaria infection are related to the spatial location of infected cells in the liver
Time of Update: 2023-01-06
"We called these cells in the liver that are unable to form infection as 'aborted hepatocytes'," said Maria Manuel Mota, head of the iMM and co-leader of the study.
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Science Advances: Exome sequencing studies discover potential therapeutic targets for diabetes
Time of Update: 2023-01-06
add5430 Through a large-scale exome sequencing association study, researchers began to use MAP3K15 as a potential target for diabetes treatment.
add5430 Through a large-scale exome sequencing association study, researchers began to use MAP3K15 as a potential target for diabetes treatment.
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Cell: Cao Peng et al. revealed the "nausea-vomiting" brain-gut transmission neural pathway
Time of Update: 2023-01-06
For the first time, Cao Peng, a researcher at the Beijing Institute of Life Sciences, and collaborators have mapped detailed neural pathways in mice from the gut to the brain, which could help scientists develop better anti-vomiting drugs for cancer patients undergoing chemotherapy.
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THE SHUMIAOAN LAB PUBLISHED A PAPER IN MOLECULAR IMMUNOLOGY
Time of Update: 2023-01-06
004Published: NOV 2022Document type: ArticleAttachment: Full text link ：Identification and functional analysis of epidermal growth factor receptor (EGFR) from Scylla paramamosain: The first evidence of two EGFR genes in animal and their involvement in immune defense against pathogen infection（IF=4.
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How certain immune cells contribute to reduced survival in patients with HER2-positive breast cancer
Time of Update: 2023-01-06
13th"In HER2-positive breast cancer patients receiving neoadjuvant therapy, when patients were first diagnosed with higher levels of tumor-infiltrating lymphocytes, the cancer was more likely to disappear from the breast and axillary lymph nodes, improving survival," said Dr. Miglietta, a researcher at the University of Padua and a medical oncologist at the Veneto Cancer Institute in Italy.
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FANG WEIHUAN'S LAB AT ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH...
Time of Update: 2023-01-06
1007/s11356-022-23506-7Published online: OCT 2022Document type: Article; Early AccessAttachment: Full text link ：Toxicological effects of fipronil on laying hens and its residue elimination in eggs（IF=5.
1007/s11356-022-23506-7Published online: OCT 2022Document type: Article; Early AccessAttachment: Full text link ：Toxicological effects of fipronil on laying hens and its residue elimination in eggs（IF=5.
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FANG WEIHUAN'S LAB AT ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH...
Time of Update: 2023-01-06
1007/s11356-022-23506-7Published online: OCT 2022Document type: Article; Early AccessAttachment: Full text link ：Toxicological effects of fipronil on laying hens and its residue elimination in eggs（IF=5.
1007/s11356-022-23506-7Published online: OCT 2022Document type: Article; Early AccessAttachment: Full text link ：Toxicological effects of fipronil on laying hens and its residue elimination in eggs（IF=5.
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Brain changes: the ongoing effects of COVID-19
Time of Update: 2023-01-06
(Marco Aurelio Romano-Silva, Federal University of Minas Gerais)Through MRI, the scientists found that sensorimotor brain regions in children who contracted COVID-19 a few months ago now show a higher demand for resources.
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Chronic jet lag has been detected in people living with HIV
Time of Update: 2023-01-06
"Delayed circadian rhythms in older Africans living with human immunodeficiency virus (HIV) According to the latest findings from researchers from universities in South Africa and the United Kingdom, the body clock in people living with HIV is significantly delayed, consistent with the symptoms of jet lag.
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Nature: Mitochondria have a waste disposal mechanism that gets rid of mutated mtDNA
Time of Update: 2023-01-06
"essayMitochondrial membrane proteins and VPS35 orchestrate selective removal of mtDNA Scientists at the University of Cologne have discovered how cells eliminate mutated mitochondrial DNA (mtDNA).
"essayMitochondrial membrane proteins and VPS35 orchestrate selective removal of mtDNA Scientists at the University of Cologne have discovered how cells eliminate mutated mitochondrial DNA (mtDNA).
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Science: A previously unknown, common mechanism by which cancer cells shut down the anti-cancer immune response
Time of Update: 2023-01-06
Original:Aberrant hyperexpression of the RNA binding protein FMRP in tumors mediates immune evasion Douglas HanahanImage source: Ludwig Cancer Research CenterA study by the Ludwig Cancer Research Center found that a single protein was expressed in high amounts in cancer cells with multiple malignancies, establishing a multilayer barrier for the anti-cancer immune response in mouse cancer models, thereby protecting tumors from immune detection and destruction.
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Nature Communications: Wang Jing/Mao Kangshan/Liu Jianquan's research group collaborates to reveal the genetic mechanism of environmental adaptation of forest tree species and future climate change...
Time of Update: 2023-01-06
With the intensification of the greenhouse effect and increasingly severe climatic conditions, climate change has posed a serious threat to biodiversity and the stability of natural ecosystems. As th
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Scientists have discovered a molecule that can help treat Parkinson's
Time of Update: 2023-01-06
Image: Dr. Tianyi Mao (left) and Dr. Haining Zhong (left), scientists at the Vollum Institute at Oregon Health and Science University, led a new study that found that adenosine effectively inhibits dopamine in the brain.
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Professor Shen Pingping's team from Nanjing University has made new progress in the field of PPAR?post-translational modification to regulate cellular metabolic reprogramming mechanism
Time of Update: 2023-01-06
The research work was supported by the National Key R&D Program of the Ministry of Science and Technology "Protein Machinery and Life Process Regulation" (2017YFA0506000) and the Guangdong Provincial Basic and Applied Basic Research Fund Regional Joint Fund Project (Key Project) (2021B1515120016。 Currently, the research results are titled "Blockage of PPARγ T166 phosphorylation enhances the inducibility of beige adipocytes and improves metabolic dysfunctions", 2022 Published online on November 3 in Cell death & Differentiation.
