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Nearly 2 million children worldwide suffer from asthma from breathing in traffic-related pollution
Time of Update: 2022-01-26
"Our study found that nitrogen dioxide puts children at risk of developing asthma, a problem that is especially acute in urban areas," said Susan Anenberg, a professor of environmental and occupational health at George Washington University and co-first author of the paper.
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Researchers develop optical biopsy system to detect liver cancer
Time of Update: 2022-01-26
The new optical biopsy system combines diffuse reflectance spectroscopy and fluorescence lifetime measurements to assess markers associated with cellular metabolism, which differ between healthy and cancerous cells .
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Science cover article: Generating CAR-T cells in vivo to treat heart damage
Time of Update: 2022-01-26
We have developed a therapeutic approach to generate transient anti-fibrotic chimeric antigen receptor (CAR) T cells in vivo by delivering modified messenger RNA (mRNA) in T cell-targeting lipid nanoparticles (LNPs) .
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Cell: The third mRNA vaccine can better protect against the Omicron variant
Time of Update: 2022-01-26
Scientists at the Ragon Institute of MGH, MIT and Harvard recently discovered that immunity against SARS-CoV-2's Omicron variant can only be developed after a booster shot of Moderna or Pfizer's mRNA vaccine.
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Study finds LRRK2 gene mutation linked to Parkinson's disease leads to iron mislocalization in brain
Time of Update: 2022-01-26
The research results were recently published in the journal PLoS Biology with the title "Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia" .
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Glucokinase (GK): remodeling the autoregulatory core "core" of blood glucose homeostasis
Time of Update: 2022-01-26
It can sensitively sense changes in glucose concentration, activate the glucose -raising/lowering mechanism of the core organs of blood glucose regulation ( pancreas, liver, and intestine ) , and timely regulate insulin, pancreatic The secretion of glucose - controlling hormones such as glucagon and GLP-1 , as well as the synthesis or decomposition of hepatic glycogen, mediate the storage and utilization of glucose, thereby maintaining blood glucose homeostasis.
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The team of Wang Yonghui of our hospital and the team of Huang Jin of East China University of Science and Technology jointly made progress in RORγt/DHODH dual-target inhibitor
Time of Update: 2022-01-26
The results of this study prove for the first time that the ROR γ t/DHODH dual-target inhibitor has potential clinical application value in the treatment of inflammatory bowel disease, and provides a new idea for the research and development of IBD therapeutic drugs .
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PNAS: Tracing brain circuits to chemotherapy 'side effect clusters'
Time of Update: 2022-01-26
Response finds new ways to understand why these debilitating diseases occur for cancer patients, and scientists should focus on all possible neurological Processes - including the central nervous system and not just the "peripheral degeneration of sensory neurons" that occurs outside the center of the body .
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Associate Professor Hou Yubo's research group's research on understanding Chinese humor from the difference sequence pattern was published in Social Psychological and Personality Science
Time of Update: 2022-01-26
Hou Yubo's research group from the School of Psychology and Cognitive Sciences, Peking University, uses the theory of differential order to reveal the internal mechanism of Chinese humor .
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Fudan University's Nature Long Article Released: Building a Global Catalog of Microbial Genes
Time of Update: 2022-01-26
, collecting 13,174 publicly available high-quality metagenomes and 84,029 high-quality Genomes of high quality, including 303 million species-level genes (95% nucleic acid consistency clustering), have constructed the most comprehensive global microbial gene catalog (Figure 1) to date, which will be used for earth ecology research and human health research.
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Nature Genetics: Can transcriptional maps of microglia guide research in brain diseases?
Time of Update: 2022-01-26
Their findings, published in the journal Nature Genetics, support the idea that microglia may play a key role in some cases of brain disease, while also providing potential guidelines for future research .
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An important cellular mechanism regulating HIV latency and discovering a high-efficiency HIV latency activator
Time of Update: 2022-01-26
On January 5th, the research group of Wang Jianhua and Chen Ling of Guangzhou Health Institute cooperated to reveal the important cell signaling pathways that regulate HIV latency, and discovered a small molecule compound that can efficiently activate latent HIV, and suggested that the compound could be used for the cure of HIV latency.
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Animal vaccines with self-spreading viruses
Time of Update: 2022-01-26
In 2000, researchers demonstrated the spread of a self-transmitted rabbit vaccine in a field trial on an island in Spain .
S. Department of Defense research agency, is also funding experiments to determine whether laboratory-modified self-transmitting animal vaccines can prevent the spread of pathogens to personnel in U.
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Functional cure for hepatitis B!
Time of Update: 2022-01-26
References:[1] VBI Vaccines Announces Dosing of First Patient in Second Phase 2 Study in Chronic Hepatitis B Patients as Part of Expansion of Clinical Collaboration With Brii Bio.
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Magic 'switch' for mammals to sense chromosome number
Time of Update: 2022-01-26
"division of labor in spaceTo study the function of the new sequences, the scientists compared their activity in stem cells, developing cells, and cells with two or only one X chromosome .
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The research of Professor Wu Yangfeng's team was selected as the best paper of the year in the New England Journal of Medicine
Time of Update: 2022-01-26
2021 New England Journal of Medicine's most noteworthy paper album coversConducted in 600 villages in 10 counties in 5 northern Chinese provinces, the study is the world's largest low-sodium study, with up to 21,000 people at high risk of cardiovascular disease enrolled , intervened and followed up for up to 5 years .
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Two "Current Biology" in the same period: Prove that air DNA can identify animals inside
Time of Update: 2022-01-26
6 issue of Current Biology, two research groups each published an independent proof-of-concept study showing that by taking air samples from a local zoo, they could collect enough DNA to identify nearby animals .
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Shanghai Jiaotong University Professor Chen Jie's team revealed the molecular mechanism of biocontrol Trichoderma degrading organophosphorus pesticide dichlorvos
Time of Update: 2022-01-26
After Sun Jianan discovered the organophosphorus pesticide hydrolase gene TaPon1-like in Trichoderma dark green T23, he further cloned 39 cytochrome P450 genes related to degradation and tolerance to dichlorvos degradation in the Trichoderma dark green T23 genome.
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Fudan and Chinese Academy of Sciences team found that limb development-related genes play a key role in the formation of fingerprint patterns, published in the main journal of "Cell"
Time of Update: 2022-01-26
He pointed out that this time, based on the concept of "testing everything can be measured", the team from Fudan and the Chinese Academy of Sciences discovered for the first time that there is a strong correlation between fingerprint patterns and limb phenotypes through large-scale collection of relevant data and analysis and research.
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A new generation of high-efficiency, low-toxicity tumor-specific IL-12 prodrugs
Time of Update: 2022-01-26
Because of the short half-life of IL-12 in the body, in order to achieve sufficient blood concentration, IL-12 is often administered intravenously for multiple times in clinical treatment, resulting in IL-12 stimulating immune cells in the activated blood circulation before reaching the tumor site , while also producing serious side effects such as dose-related cytokine storm or liver or other organ tissue damage .
