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Obesity linked to cancer — and now we finally know part of it
Time of Update: 2022-02-20
Associate Professor Nils HalbergThe researchers found that changes in the environment surrounding the cancer cells, from a normal-weight body to an overweight or obese body, prompted the cancer cells to adapt .
"This means that obesity increases the risk of tumor formation even in the absence of new genetic mutations," said Associate Professor Nils Halberg .
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Late-life exercise shows rejuvenating effect at the cellular level
Time of Update: 2022-02-20
"Exercise in later life slows epigenetic aging in skeletal muscle," according to a recent study published in the journal Aging Cell .
" Thus, researchers can use one of a series of "methylation clocks" to determine the age of a DNA sample .
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Your eyes may reveal your true biological age -- and the causes of your illness and death
Time of Update: 2022-02-20
Except for cardiovascular disease or cancer, a larger retinal age gap was significantly associated with a 49%-67% increased risk of death .
However, they write: "Our new findings have established that retinal age gap is an independent predictor of increased risk of death, particularly non-cardiovascular/non-cancer mortality .
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Molecular mechanism of bacterial effector proteins antagonizing host antibacterial autophagy and a general mechanism of cell-selective autophagy
Time of Update: 2022-02-20
On January 19, 2022, the research group of Wang Dacheng/Ding Jingjue from the Institute of Biophysics, Chinese Academy of Sciences and Shao Feng's team from the Beisheng Institute published a paper entitled "ARF GTPases activate Salmonella effector SopF to ADP- " in " Nature Structural & Molecular Biology " ribosylate host V-ATPase and inhibit endomembrane damage-induced autophagy" research paper .
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First gene-edited pig kidney transplanted into brain-dead human
Time of Update: 2022-02-20
In the study, published in the American Journal of Transplantation, UAB researchers tested the first preclinical model of transgenic pig kidneys transplanted into humans .
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Science｜Professor Qu Lijia made another major textbook-level discovery
Time of Update: 2022-02-20
The molecular mechanism of the model plant Arabidopsis thaliana preventing polyfertilization through small peptide signaling and its receptor-mediated signaling pathway is revealed, that is, only one pollen tube per ovule is allowed to penetrate the septum of the stylar canal to enter it for fertilization .
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Nature: DNA mutations are not random "mutation preferences reflect natural selection in Arabidopsis"
Time of Update: 2022-02-20
"We've always thought of genetic mutations as basically random," said Grey Monroe, an assistant professor in the UC Davis Department of Plant Sciences and lead author of the paper .
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New discovery: Targeting bone cells better at targeting leukemia than malignant stem cells?
Time of Update: 2022-02-20
In the same study, Kousteni and Galán-Díez observed continuously elevated levels of kynurenine and SAA1 in patients with AML and in patients with myelodysplastic syndrome (MDS) .
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The Qinghai Provincial Key Laboratory of Animal Eco-Genomics has made new progress in the study of energy metabolism in plateau pikas at different altitudes
Time of Update: 2022-02-19
The Qinghai Provincial Key Laboratory of Animal Ecogenomics captured plateau pika at different altitudes, measured the resting metabolic rate of plateau pika, and further determined the expression levels of metabolic heat production-related genes in adipose tissue, liver and skeletal muscle.
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Aging neurons hinder neurogenesis in mice
Time of Update: 2022-02-19
. "These results support the idea that senescence-dependent accumulation of senescent cells, including senescent stem cells in the hippocampal niche, negatively affects normal stem cell function and adult neurogenesis, leading to age-dependent cognitive decline in the hippocampus .
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Why do people walk?
Time of Update: 2022-02-19
Through fluorescent labeling, the researchers found that the VSCT located near the motor neurons was in a highly excited state, indicating that the operation and neural electrical activity of the two types of neurons were synchronized .
For example, researchers will use light to regulate the active state of VSCT in mice.
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ACE2 receptor protein "nanobubbles" can prevent new crowns
Time of Update: 2022-02-19
Science and Technology Daily, Beijing, January 23 (Intern reporter Zhang Jiaxin) According to a paper published in the journal "Nature Communications" on the 20th, scientists from Northwestern Univers
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Xiong Daxi's team of Suzhou Institute of Medical Technology has made progress in the field of LED solar simulation technology
Time of Update: 2022-02-19
Figure 1 Solar Simulator Graphical Summary Recently, Sun Chao, Jin Zhiliang and others of Xiong Daxi's team of Suzhou Institute of Medical Technology, Chinese Academy of Sciences designed a distributed high thermal conductivity single crystal COB package based on a high-power vertical structure narrow-band LED light source to achieve high optical power density and stable output .
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Newly discovered ALS gene
Time of Update: 2022-02-19
But Sai Zhang, PhD, lecturer in genetics and one of the lead authors of a paper describing the study, devised a way to search through massive datasets and find genes associated with a disease, in this case ALS.
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Huang Ying's team made new progress in the study of the speciation mechanism of Streptomyces
Time of Update: 2022-02-19
The above research results were published in the journal mBio under the title "Habitat adaptation drives speciation of a Streptomyces species with distinct habitats and disparate geographic origins" (DOI: 10.
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KRAS Inhibitors: Positive Phase 2 Results in Pancreatic and Gastrointestinal Cancers
Time of Update: 2022-02-19
In a cohort of previously treated patients with pancreatic duct adenocarcinoma and other gastrointestinal (GI) cancers with KRAS G12C mutation, adagasib demonstrated significant clinical activity and broad disease control .
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New progress in Cd immobilization strategy and evaluation in heavy metal polluted farmland in South China Botanical Garden
Time of Update: 2022-02-19
Zhian Li's team from the Ecology Center of the South China Botanical Garden of the Chinese Academy of Sciences combined in situ soil cadmium immobilization and bioavailability-corrected health risk assessment ( HRA ) to minimize the risk of cadmium exposure and evaluation uncertainty caused by rice consumption .
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Li Haipeng's research group from the Institute of Nutrition and Health established an accurate human genetic recombination map based on machine learning cooperation
Time of Update: 2022-02-19
0 to analyze publicly available UK10K sequencing data of a total of 3,781 unrelated individuals (n=7,562 genomes) based on Out-of-Africa The population history model accurately estimates the genetic recombination rate and builds an accurate genetic recombination map .
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CDK4/6: New insights into old targets
Time of Update: 2022-02-19
▲ The mechanism by which CDK4/6 regulates cell cycle progression (Image source: Reference [1])Three of the inhibitors developed based on inhibition of CDK/6 activity have been approved by the US FDA for the treatment of HR-positive, HER2-negative advanced or metastatic breast cancer, including Pfizer's palbociclib, Novartis' ribociclib and Eli Lilly's abemaciclib .
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New crown "brain injury"?
Time of Update: 2022-02-19
Research results (Source: bioRxiv)The study found that SARS-CoV-2-infected mouse models had significantly elevated cytokine profiles in serum and cerebrospinal fluid (CSF) at 7 days and 7 weeks after respiratory infection compared with control mice .
