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Mouse study reveals role of ion channel in COPD
Time of Update: 2022-02-21
"The researchers investigated TRPML3 expression and function in the lung to elucidate how MMP12 concentrations are regulated .
"Their findings suggest that TRPML3 is a key regulator of MMP-12 uptake by alveolar macrophages and could be a therapeutic target for COPD .
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USTC Cell Res discovers a novel substrate binding and transport mechanism of human bile acid efflux protein ABCB11
Time of Update: 2022-02-21
<> </> Recently, the research group of Professor Chen Yuxing and Professor Zhou Congzhao from the Department of Life Science and Medicine, University of Science and Technology of China, used single-particle cryo-electron microscopy to analyze the three-dimensional complexes of a series of human bile acid efflux protein ABCB11 and its physiological substrate, sodium taurocholate.
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Hope to grow taller?
Time of Update: 2022-02-21
Instead, the Evseenko lab used their understanding of the nuances of STAT3 and its associated genes and proteins to develop a highly targeted drug with the potential to regenerate articular cartilage without triggering inflammation .
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Skip sequencing, new technology will shorten vaccine and monoclonal antibody therapy development
Time of Update: 2022-02-21
For example, in a study published in the journal Nature Communications in August, researchers used high-resolution cryo-electron microscopy (cryo-EM) to rapidly and precisely map antibodies in rhesus monkeys with Where synthetic versions of the HIV envelope protein bind, which are being developed for potential HIV vaccines .
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23andMe team targets loci associated with loss of smell and taste in COVID-19 patients
Time of Update: 2022-02-21
After conducting an online survey of 23andMe study participants about their COVID-19 experiences and symptoms, the researchers conducted a genome-wide association study and found that sites near the UGT2A1 and UGT2A2 genes are associated with loss of smell and taste .
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On January 17, 2022, Shen Li's laboratory jointly published a paper in Leukemia to analyze the protective effect of HMCES on long-term hematopoietic stem cells and propose new targets for leukemia treatment
Time of Update: 2022-02-21
Therefore, the protection of AP sites on single-stranded DNA by HMCES and the regulation of DNA damage repair pathways jointly ensure that LT-HSCs maintain genome stability and self-renewal capacity during stress hematopoiesis .
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A New Treatment Technique: Collagen Imaging
Time of Update: 2022-02-21
Using newly developed imaging techniques, researchers from the Medical University of South Carolina, in collaboration with researchers at the Heart Institute of the University of Ottawa in Canada (BEaTS team, have revealed the therapeutic use of injectable collagen materials in the treatment of heart disease potential .
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Scientists identify therapeutic target for Epstein-Barr virus
Time of Update: 2022-02-21
"This virus is smart and uses the same mechanisms that regulate the conformation of the human genome to regulate its own gene expression," said Tempera .
Morgan, Hideki Tanizawa, Lisa Beatrice Caruso, Michael Hulse, Andrew Kossenkov, Jozef Madzo, Kelsey Keith, Yinfei Tan, Sarah Boyle, Paul M.
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Li Liming's team The BMJ's "China's Strategy and Experience in Fighting the New Crown Epidemic" album tops the top ten medical science and technology news in China in 2021
Time of Update: 2022-02-21
"British Medical Journal" " China's strategy and experience in fighting the new crown epidemic " album coverSince 2015 , Health News has completed the domestic and international " Double Ten Major " medical science and technology news selection for 7 consecutive years .
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Loss-of-function mutations in the co-chaperone BAG5 cause dilated cardiomyopathy requiring heart transplantation
Time of Update: 2022-02-21
BAG5 localizes to junctional membrane complexes (JMCs), and mutant mouse cardiomyocytes upon catecholamine stimulation display disordered JMC structure and abnormal calcium handling .
bag 5- Mutant mouse cardiomyocytes exhibit decreased functional JMC protein abundance, disordered JMC structure, and abnormal calcium handling upon catecholamine stimulation .
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Using high-field magnetic resonance to reveal the distribution of fine representations within face-processing brain regions
Time of Update: 2022-02-21
In high-level visual processing brain regions such as the temporal lobe object recognition processing network, the spatial organization of functions in the brain structure is mainly found on larger spatial scales, reflecting the spatial organization relationship between neural nuclei that process different object categories .
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Yale scientists track longevity and multiple functions of messenger RNA
Time of Update: 2022-02-21
In one of the new studies, a team led by Nicole Martinez, a postdoctoral researcher in Gilbert's lab, found that pseudouridine plays a key role in the formation of mRNAs .
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"Science" Third dose of BNT162b2 protects against Omicron variants
Time of Update: 2022-02-21
Alexander Muik and colleagues tested the original pseudovirus, Beta pseudovirus, Delta pseudovirus, or Omicron pseudovirus with sera from 51 participants who received two to three doses of the mRNA-based COVID-19 vaccine BNT162b2 .
abn7591Article TitleNeutralization of SARS-CoV-2 Omicron by BNT162b2 mRNA vaccine-elicited human sera
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2022-01-20 USTC discovers a novel substrate binding and transport mechanism of human bile acid efflux protein ABCB11
Time of Update: 2022-02-21
<> </> Recently, the research group of Professor Chen Yuxing and Professor Zhou Congzhao from the Department of Life Science and Medicine, University of Science and Technology of China, used single-particle cryo-electron microscopy to analyze the three-dimensional complexes of a series of human bile acid efflux protein ABCB11 and its physiological substrate, sodium taurocholate.
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What effect does estrogen have on the sense of smell?
Time of Update: 2022-02-21
Using this transgenic zebrafish, combining chemical and genetic methods to manipulate these estrogen-responsive cells, revealed a new function for estrogen in embryonic brain development .
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Nobel Laureate Reveals Cause of Indirect Carcinogenicity of Milk/Beef
Time of Update: 2022-02-21
The team discovered the presence of BMMF in cells adjacent to tumors in colon cancer patients, and further discovered that BMMF triggers local chronic inflammation, leading to elevated levels of reactive oxygen species (ROS) .
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Israel: Fourth dose of Pfizer vaccine has limited efficacy against Omicron
Time of Update: 2022-02-21
The researchers found that two weeks after the fourth dose of Pfizer's vaccine, antibody levels in the test subjects rose, but protection against omicron was limited .
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PNAS special issue looks ahead to the future of plant genome sequencing
Time of Update: 2022-02-21
Given the importance of plant genome sequencing, several botanists wrote the article titled "Green Plant Genomes: What We Know in an Era of Rapidly Expanding Opportunities" .
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Nature Medicine: Sustained T cell responses to Omicron after infection and vaccination
Time of Update: 2022-02-20
"Together with viral factors, such as lower levels of viral replication in the lower respiratory tract, and other immune components, these results give us a clearer picture that may explain why previously vaccinated individuals with mRNA remain well protected from severe Omicron disease ” said lead researcher Marcus Baggett of the Center for Infectious Diseases Medicine at Karolinska Institutet .
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The new version of the Cas3 protein increases the efficiency of direct gene editing in stem cells to 50%
Time of Update: 2022-02-20
"However, the Cas9 tool does have limited capabilities for large-scale gene editing," said Yan Zhang , Ph. D.
"This type of Cas11 protein is like a hidden gem that we and other researchers have not discovered until recently," Zhang said .
