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Big data analysis of "The Lancet" sub-issue: Step count and health are the most obvious
Time of Update: 2022-02-25
In addition to the number of steps, other factors strongly associated with clinical outcome, in order of strength of association, were: moderate to vigorous physical activity, total physical activity, number of activities, light physical activity, and sedentary behavior .
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Vaccine development has been in vain, new drug therapies have been emerging to fight "AIDS" for 40 years, and there is more hope if there are setbacks
Time of Update: 2022-02-25
Highly potent antiretroviral drugs have transformed AIDS from a fatal disease into a treatable but incurable chronic disease; broad-spectrum neutralizing antibodies that block HIV before cells infect are already in clinical trials Experiments and explorations; but the research on AIDS vaccines has been "difficult to give birth", and efforts have been unsuccessful .
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NICE recommends Roche risdiplam for spinal muscular atrophy
Time of Update: 2022-02-25
CompilationFan DongdongNICE UK has released draft guidelines recommending Roche risdiplam (Evrysdi) as part of a managed access agreement (MAA) for the treatment of the rare genetic disease spinal muscular atrophy (SMA) .
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New discovery!
Time of Update: 2022-02-25
Using mouse models, researchers found that stress hormones may suppress the innate immune system that normally protects the body's gut against invasive Enterobacteriaceae, a group of bacteria that includes Escherichia coli and C.
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Everything can be connected!
Time of Update: 2022-02-25
References:[1] Acepodia Raises $109 Million Series C Financing to Advance Development of First-in-Class Antibody Cell Effector Therapies.
Retrieved December 2, 2021, from https:// /2345016/0/en/Acepodia-Raises-109-Million-Series-C-Financing-to-Advance-Development-of-First-in-Class-Antibody-Cell-Effector-Therapies.
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75% of the genes in the human body are garbage?
Time of Update: 2022-02-25
Gu Chaojiang introduced that according to the early definition, the number of genes responsible for encoding proteins in human genes is only 40,000, accounting for only 2% of the genome, and the other 98% are classified as "junk DNA" .
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Nature: A new target for cancer immunotherapy - GABA
Time of Update: 2022-02-25
Source: NatureCollectively, this study demonstrates that GABA secreted by B cells can activate anti-inflammatory macrophages and inhibit the antitumor response of CD8 T cells through GABAA receptors .
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Adjuvant Keytruda gets FDA approval to treat more melanoma patients
Time of Update: 2022-02-25
(MSD), as an adjuvant therapy for the treatment of patients with stage IIB and IIC melanoma (over 12 years old) who have undergone surgical resection .
Retrieved December 3, 2021, from https:// -immunotherapy-prolongs-recurrence-free-survival-in-resected-stage-ii-bc-melanoma
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Discovery of genes that play important roles in antibody formation
Time of Update: 2022-02-25
Researchers at the University of Toronto in Canada have discovered that a neglected gene called FAM72A plays an important role in the formation of antibodies by promoting the production of high-quality antibodies through activation-induced deaminase (AID), which aids in immunity The system identifies and combats the new coronavirus, bacteria and other viruses that cause infectious diseases .
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Targeting microglia in the brain may help prevent and treat Alzheimer's disease
Time of Update: 2022-02-25
The findings were published in the December 1, 2021 issue of Science Translational Medicine with the title "AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation" .
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Stem cell model reproduces early human embryonic development
Time of Update: 2022-02-25
According to a study published in the British "Nature" magazine on the 2nd, scientists used human pluripotent stem cells to establish a model that can be used to study the process of human embryo implantation into the uterus .
Models that accurately simulate this developmental stage can support studies of embryo implantation and early development .
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Experimental chewing gum may reduce the spread of new coronavirus
Time of Update: 2022-02-25
International war "epidemic" operationScience and Technology Daily, Beijing, December 6th (intern reporter Zhang Jiaxin) A new study shows that chewing gum containing high levels of angiotensin-converting enzyme 2 (ACE2) protein can "capture" new coronavirus particles and reduce the viral load in saliva.
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Hurry up and learn the classification of "garbage" in the blood vessels!
Time of Update: 2022-02-25
Usually ultrasound examination of the internal echo of plaque is divided into the following types from low to high:The main components of low echo are lipids (cholesterol), old bleeding, and inflammatory cells .
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STAT3 protein degraders exhibit anticancer activity by increasing tumor sensitivity to PD-1 inhibitors
Time of Update: 2022-02-25
▲KTX-201 changes the tumor microenvironment (Image source: Kymera official website)Moreover, when KTX-201 was combined with an anti-PD-1 antibody, it resulted in a 60% complete remission in a mouse model of solid tumors, and the animals gained immune memory and the growth of re-implanted tumors was inhibited .
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There is a lot of knowledge in outdoor equipment. The critical moment should not be underestimated
Time of Update: 2022-02-25
Xie Xiaojun told reporters that the materials of outdoor work equipment are not "ordinary", and many of them are high-tech .
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Which is better, stent or bypass for left main coronary artery disease?
Time of Update: 2022-02-25
However, the optimal revascularization strategy for patients with left main coronary artery disease with moderate to low anatomical complexity is uncertain, drug-eluting stent percutaneous coronary intervention (PCI) versus coronary artery bypass grafting ( CABG, "Bridging" technique) has always been controversial .
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The National Cancer Center's latest release: More than half of patients with these 5 common cancers are diagnosed at an advanced stage
Time of Update: 2022-02-25
" , promoting the development of early screening and testing programs in the future, and even improving medical access are important!The current multicenter, hospital-based observational study included 23 hospitals in 12 provincial-level regions in China, and focused on five common cancers in China: lung, stomach, esophagus, colorectal, and breast cancer .
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The first domestically produced new crown neutralizing antibody combination therapy was approved by the State Food and Drug Administration
Time of Update: 2022-02-25
It is reported that the State Food and Drug Administration, in accordance with the relevant provisions of the "Drug Administration Law" and in accordance with the special drug approval procedures, conducted emergency review and approval, and approved the combination of the above two drugs for the treatment of mild and common types with progression to severe (including hospitalization or Death) adults and adolescents (12-17 years old, body weight ≥40kg) patients with novel coronavirus infection (COVID-19) with high risk factors .
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NMPA plans to adjust the "Catalogue of Medical Devices Prohibited from Entrusted Production" to refine relevant medical and aesthetic items
Time of Update: 2022-02-25
On November 19, the State Food and Drug Administration issued the "Catalogue of Medical Devices Prohibited from Entrusted Production (Draft for Comment)" .
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Fat-burning target found to burn calories while lying down
Time of Update: 2022-02-25
More importantly, IL-27 can improve type 2 diabetes, providing new targets and potential drugs for the treatment of obesity and related metabolic diseases .
