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Science: The regulatory mechanism of mechanical stress on heart valve formation
Time of Update: 2022-02-26
ATP regulates Ca2+ influx, and extracellular ATP analogs can significantly enhance Ca2+ influxIn the present study, the researchers identified ATP-Ca2+ as an extended regulatory channel formed in cardiovascular formation and valve development, through which hemodynamic mechanical forces can guide heart valve development .
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Microbial catalyzed ceramic material promotes bone tissue regeneration
Time of Update: 2022-02-26
Science and Technology Daily News (Reporter Wang Chun) The reporter learned from the Shanghai Institute of Ceramics, Chinese Academy of Sciences on November 22 that the Wu Chengtie research team of the institute proposed the idea of microbial catalytically active minerals to induce osteogenesis, and used microbial catalysis to construct a Surface micro-nano structures of bioceramic scaffolds for bone tissue regeneration .
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Closely connected to the new crown but not infected!
Time of Update: 2022-02-26
The researchers found that in these health care workers who can naturally defend against the new coronavirus, some memory T cells are cleared of infected cells that express the virus's "transcriptional replication complex" (RTC) .
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"Top priority"!
Time of Update: 2022-02-26
Recently, "Dermatologic Surgery" published a research article entitled "The Effect of Conditioned Media From Human Adipocyte-Derived Mesenchymal Stem Cells on Androgenetic Alopecia After Nonablative Fractional Laser Treatment".
Media From Human Adipocyte-Derived Mesenchymal Stem Cells, ADSC-CM) significantly increases hair density and volume in AGA patients .
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Arvinas/Pfizer Announces Latest Clinical Results of "Star" PROTAC Therapy
Time of Update: 2022-02-26
A few days ago, Arvinas and Pfizer jointly announced that the latest phase 1 clinical results of the jointly developed PROTAC protein degradation therapy ARV-471 will be presented at the San Antonio Breast Cancer Symposium (SABCS) in early December .
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NK cell therapy for non-small cell lung cancer enhances Keytruda's anticancer activity
Time of Update: 2022-02-26
Recently, NKGen Biotech announced that the autologous natural killer (NK) cell therapy SNK01, in combination with the PD-1 inhibitor pembrolizumab (Keytruda), is used in the treatment of non-small cell lung cancer (NSCLC) 1 / Phase 2a clinical trial with positive data .
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my country's new crown special medicine may be a "dark horse" to prevent mutant strains!
Time of Update: 2022-02-26
What is more unique is that when most of the other candidate drugs use "a pair of antibodies" to prevent the escape of the new crown virus, DXP-604 realizes that "a single antibody" can Protection against mutants .
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This article tells you why children's new crown vaccine doses are the same as adults
Time of Update: 2022-02-26
During the clinical research process, the developers of the new crown vaccine conducted group trials of high, medium and low doses for adults and children, and found that the immune effects of adults and children at the same dose were basically the same .
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Is there any advantage to the rapid replacement of CAR-T in cell therapy technology?
Time of Update: 2022-02-26
In August of this year, Novartis announced that the second-line CD19 CAR-T therapy Kymriah, a Phase 3 clinical trial of BELINDA in the treatment of aggressive B-cell non-Hodgkin's lymphoma (B-NHL), failed to meet the primary endpoint of EFS .
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Oncolytic virus CG0070 achieves 100% CR in high-risk bladder cancer patients Domestic Lepu Biotech has obtained clinical approval
Time of Update: 2022-02-26
Results of the trial showed that of 9 patients with non-muscle-invasive bladder cancer (NMIBC) who were evaluable for efficacy in Bacille Calmette-Guerin (BCG) non-responsive, all achieved complete remission (CR) at 3 months, and in addition, 6 The CR rate of patients at the monthly and 9-month assessment nodes also remained at 100% .
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High-resolution HIV capsid structure map identified
Time of Update: 2022-02-26
Science and Technology Daily, Beijing, November 22 (intern reporter Zhang Jiaxin) The British Electronic Bioimaging Center (eBIC) used new technologies of electron tomography and subpixel tomographic averaging to identify the HIV capsid protein, and its relationship with Composite structural image of host cytokine interactions at ~5.
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Empowering new drug discovery researchers to develop the first rat model that fully mimics human AD
Time of Update: 2022-02-26
Through a head-to-head comparison study with AppNL-GF mice, Professor Lu Bai's team pointed out that from the persistent death of nerve cells and the resulting brain atrophy, as well as tau protein pathology, another key feature of Alzheimer's disease, etc.
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Research develops a new 'magic bullet' therapy that promises to treat patients with acute myeloid leukemia
Time of Update: 2022-02-26
Expression of high sialic acid-binding immunoglobulin-like lectin (Siglec)-15 on the surface of circulating blood cells in patients with acute myeloid leukemia (AML)Image credit: DOI: 10.
Researcher Cao explained that we are currently looking for a new way to treat leukemia by using targeted antibody therapy called "magic bullet".
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BMS Oral Kinase Inhibitor Inrebic Approved by UK NICE for Myelofibrosis
Time of Update: 2022-02-26
CompilenewbornThe UK National Institute for Health and Clinical Excellence (NICE) recently issued a final assessment decision (FAD) recommending the use of Bristol-Myers Squibb's oral kinase inhibitor Inrebic (fedratinib) in the NHS for the treatment of bone marrow Fibrosis, a rare blood cancer that affects the bone marrow and disrupts the production of blood cells in the body .
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New breakthrough!
Time of Update: 2022-02-26
At present, the research and development of AIDS vaccine focuses on the balance of humoral and cellular immune responses.
In September 2009, the new combined vaccine (RV144) developed by the US military and Thailand can reduce the risk of HIV infection by 31.
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Illuminate DNA "dark matter"!
Time of Update: 2022-02-26
In a study published in the journal Cell, a team led by Professor Ren Bing from the University of California, San Diego (UCSD) used a key non-coding region to draw a single-cell chromatin map of the human genome, helping us understand many Mechanisms of disease provide important data support .
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Lifetech G-Branch(TM) Thoracic and Abdominal Aortic Stent Graft System Approved for Innovation Green Channel
Time of Update: 2022-02-26
This product is used for endovascular treatment of thoracic and abdominal aortic aneurysms, which is the first of its kind in China, and is the Group's 14th innovative product approved to enter this "green channel" .
G-Branch™ Thoracic and Abdominal Aortic Stent Graft System is an important product of Lifetech in its total endoluminal aortic treatment platform.
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Biogen's next-generation fumaric acid product, Vumerity, has been approved by the UK MHRA
Time of Update: 2022-02-25
CompilenewbornBiogen Vumerity (diroximel fumarate), a next-generation oral fumarate therapy for the treatment of relapsing-remitting multiple sclerosis (RRMS), has been approved by the Medicines and Healthcare Products Administration (MHRA) in the United Kingdom .
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New crown mortality rate: not vaccinated more than ten times higher than fully vaccinated
Time of Update: 2022-02-25
According to a recent report on the website of the British "New Scientist" magazine, the US Centers for Disease Control and Prevention recently released data showing that unvaccinated people in the United States are 14 times more likely to die from the new coronavirus than fully vaccinated people, and the probability of testing positive for the new coronavirus is 6 times the rate .
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Big data analysis of "The Lancet" sub-issue: Step count and health are the most obvious
Time of Update: 2022-02-25
In addition to the number of steps, other factors strongly associated with clinical outcome, in order of strength of association, were: moderate to vigorous physical activity, total physical activity, number of activities, light physical activity, and sedentary behavior .
