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New technology "Space-CUT&Tag" maps the mechanism of tissue development
Time of Update: 2022-03-07
In a new study published in the journal Science, Yale University researchers, in collaboration with researchers at Karolinska Institutet, have developed a technique that provides insights into the location of activated and deactivated genes in specific tissues very precise information .
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PD-(L)1 Clinical Development Challenges and Opportunities: Over 80% of Combination Therapy in Nearly 5,000 Clinical Trials
Time of Update: 2022-03-07
(Source: Nature Reviews Drug Discovery)As anti-PD1/PDL1 clinical trials continue to move toward a combined strategy, the authors update their analysis of the targets pursued by such models .
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Zhao Bingqiao's team revealed that the small molecule drug MLN4924 improves neurovascular injury in stroke
Time of Update: 2022-03-07
Zhao Bingqiao's team from Fudan University's Institute of Brain Science/State Key Laboratory of Medical Neurobiology published a study titled "The NEDD8-activating enzyme inhibitor MLN4924 reduces ischemic brain injury in mice" online in PNAS, the journal of the National Academy of Sciences.
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Prevent tumor metastasis by putting cancer cells to sleep
Time of Update: 2022-03-07
A new treatment stops the growth of metastatic tumors in mice by forcing cancer cells into a dormant state where they cannot proliferate .
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"Immunity" Lactobacillus disrupts immunosuppression and stimulates tumor growth
Time of Update: 2022-03-07
The study found that lactic acid bacteria promote the growth of pancreatic duct cancer by activating tumor associated macrophages (TAMs) by metabolizing tryptophan in food .
The results showed that Lactobacillus activates AhR in tumor-associated macrophages by metabolizing tryptophan, which ultimately promotes pancreatic cancer growth and subverts the inhibitory effect of immune checkpoints .
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Bacteria's hidden weapon: toxins held in capsules by corks
Time of Update: 2022-03-07
One of these toxic proteins, the 3D structure of the bacterial RhsA effector protein, has now been solved by the team of Stefan Raunser and John Whitney .
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P53 protein plays a key role in tissue repair, study finds
Time of Update: 2022-03-07
Image: Artistic representation of a leader cell directing the migration of its neighbors (followers) to repair woundsSource: Ella Marushenko StudioA new study led by the University of Bristol has found that the p53 protein plays a key role in epithelial cell migration and tissue repair .
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AI-generated faces are more trustworthy than real ones
Time of Update: 2022-03-07
Haney Farid of UC Berkeley conducted an experiment in which participants were asked to distinguish between synthetic and real faces, as well as the skill level of these people.
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The long new crown may be related to the effect of SARS-CoV-2 on the vagus nerve
Time of Update: 2022-03-07
The authors propose that SARS-CoV-2-mediated vagus nerve dysfunction (VND) may explain some of the long-standing COVID-19 symptoms, including dysphonia (persistent speech problems), dysphagia (dysphagia), dizziness, and tachycardia (abnormally high heart rate), orthostatic hypotension (low blood pressure), and diarrhea .
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BIO-TECHNE Announces Release of New Data Demonstrating Correlation of EXODX Prostate Test with Post-Prostatectomy Pathology Outcomes
Time of Update: 2022-03-07
Dr Alexander Kretschmer, a urologist from Ludwig Maximilian University in Munich, Germany, said: "From a clinical point of view, active surveillance (AS) is underutilized in patients with low-risk localized prostate cancer and more tools are needed to inform AS This study showed that the EPI test accurately identified men with GG1 at biopsy (RP) compared with men who were upgraded to ≥GG3 (p < 0.
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Yale Cancer Center study confirms treatment for aggressive bladder cancer
Time of Update: 2022-03-07
Image: ASCO GU 2022Source: Yale Cancer CenterA new study led by Yale Cancer Center researchers finds that enfortumab vedotin is effective in patients with muscle-invasive bladder cancer (MIBC) who are not eligible for cisplatin chemotherapy .
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Tang Shiming's research group and collaborators reveal the encoding mechanism of brain sequence memory
Time of Update: 2022-03-07
Tang Shiming's group, in collaboration with Wang Liping and Min Bin, used long-term awake monkey two-photon imaging technology to record the activity of thousands of neurons in the prefrontal cortex of macaque monkeys performing sequential memory .
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Acid-controlled Ber@ZnO-ZIF-8 nano-pesticide formulations efficiently control tomato bacterial wilt
Time of Update: 2022-03-07
Disease" research paper, which established a new method for the acid-controlled release of berberine from the ZnO@ZIF-8 nanocore- shell structure to synergistically and efficiently control tomato bacterial wilt .
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Researchers unveil largest catalog of gene activators to date
Time of Update: 2022-03-07
The study was led by Mikko Taipale, associate professor of molecular genetics at the Donnelly Center for Cell and Biomolecular Research at the Temerty School of Medicine, with Anne-Claude Kingra, a senior investigator at the Lunenfeld-Tanenbaum Institute.
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Ge Feng and Sun Yucheng's team revealed the immune homeostasis regulation mechanism of B. tabaci's efficient virus transmission
Time of Update: 2022-03-07
On February 11, 2022, the team of researchers from the Institute of Zoology, Chinese Academy of Sciences and the Center for Excellence in Biological Interaction, Chinese Academy of Sciences, Ge Feng and Sun Yucheng, published a research titled "PEBP balances apoptosis and autophagy in whitefly upon arbovirus infection" in Nature Communications In this paper, it was found that Phosphatidylethanolamine-binding protein 4 (PEBP4) is a key molecule in regulating the intracellular immune homeostasis of B.
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Baker's yeast and anti-aging therapy
Time of Update: 2022-03-07
"Using current yeast strains, up to 5 tonnes of DLA can be produced per year, and with further optimization, commercial production levels can be reached," explains Yew Wen Shan, Associate Professor, Department of Biochemistry, NUS Faculty of Medicine, and co-principal investigator of the study .
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Study: New crown vaccine may help fight colds
Time of Update: 2022-03-07
Ulm University Hospital in Germany recently issued a press release saying that a new study found that vaccination against the new crown can not only effectively prevent the occurrence of severe new crowns, but may also play a role in inhibiting other coronaviruses and help people fight against diseases such as the common cold .
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Nature sub-journal: How to repair damaged gut?
Time of Update: 2022-03-07
In a recently published article, researchers at Tokyo Medical and Dental University (TMDU) present a detailed protocol for transplanting 3D cellular structures that regenerate intestinal tissue damaged in colitis .
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Brain training with neurofeedback can enhance cognitive function
Time of Update: 2022-03-07
Previous studies have reported a positive correlation between increased brain activity during brain training and improved cognitive function, and the research team is eager to discover whether brain training, which enhances brain activity through neurofeedback, has a positive effect on cognitive performance influence .
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New drug combination effective for patients with advanced ovarian cancer
Time of Update: 2022-03-06
"With the limited number of effective combinations currently available to treat patients, new treatments for recurrent ovarian cancer are urgently needed .
The results of this study suggest that a drug combination may be an effective treatment for this type of ovarian cancer, " said Alessandro Santin, M.
