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Degeneration of neurons, not sleep deprivation, makes Alzheimer's patients drowsy
Time of Update: 2022-04-16
"We were able to show what our previous research had pointed out -- that in Alzheimer's patients who need to nap all the time, the disease damages the neurons that keep them awake," says neuropathologist Grinberg, who works with psychiatrists J.
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Study finds inhibition of PDK1 holds promise for acute myeloid leukemia
Time of Update: 2022-04-16
Related research results were recently published in the journal Nature Communications with the title "The Glycolytic Gatekeeper PDK1 defines different metabolic states between genetically distinct subtypes of human acute myeloid leukemia" .
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The "root" of obesity in "Cell Metabolism" may be in the liver!
Time of Update: 2022-04-15
In a groundbreaking discovery, scientists from the University of Texas Health Sciences Center in San Antonio (UT Health San Antonio) report that inhibiting liver enzymes in obese mice reduces appetite in rodents, increases energy expenditure in adipose tissue and contributes to body weight lighten .
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Nature Genetics identifies strong genetic risk factors for bipolar disorder for the first time
Time of Update: 2022-04-15
The study was led by scientists at the Stanley Center for Psychiatric Research at the Broad Institute of MIT and Harvard, who worked with colleagues around the world Collaborating to identify a gene called AKAP11 as a strong risk factor for bipolar disorder and schizophrenia .
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Study analyzes effects of DiNP on colon
Time of Update: 2022-04-15
To see if DiNP was harmful, the team used different doses of DiNP to test how it affected the gut lining, immune system and colonic microbes .
Of all genera present in the gut, two species of lachnoclostrium and blautia differed in dinp-treated mice from controls .
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Specific gene linked to schizophrenia identified for the first time
Time of Update: 2022-04-15
For the first time, the SCHEMA Consortium paper has identified extremely rare protein-interfering mutations in 10 genes that greatly increase an individual's risk of developing schizophrenia .
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How polygenes influence vision development and cause rare vision impairment
Time of Update: 2022-04-15
Now, in a study published in the journal Ophthalmology, researchers combining data from more than 900 cases around the world have been able to determine the spectrum of genetic changes behind these foveal defects -- critically, they occur in During the development of the unborn baby .
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Molecules produced by cells in response to stress may be indicators of various diseases
Time of Update: 2022-04-15
A new study led by researchers at Massachusetts General Hospital (MGH) and published in the journal Advanced Science shows that cells normally release certain RNA molecules called tDRs, In response to stressors, different tDRs may act as markers of cellular stress in different diseases .
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Can licorice be used to treat cancer?
Time of Update: 2022-04-15
Munirathinam and student researchers conducted a research review of a licorice-derived substance called glycyrrhizin that is used to prevent or treat cancer, suggesting that further research may lead to specific drugs for clinical use .
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A new model to detect and treat recurrence of lung cancer
Time of Update: 2022-04-15
But researchers at the University of Missouri School of Medicine have identified a way to study the role and vulnerability of circulating tumor cells to cancer recurrence in patients with non-small cell lung cancer .
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Climate warming leads to the radial growth rate of Toona sinensis in the tropical and subtropical regions of Yunnan...
Time of Update: 2022-04-15
Under the scenario of future climate warming, the growth rate and forest productivity of Toona sinensis in tropical and subtropical regions of Yunnan may further decrease, thus threatening the ecological service function of such forests .
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A compound may aid weight loss, increase muscle strength, and reduce inflammation associated with aging
Time of Update: 2022-04-15
Aged mice fed BAM15 lost fat, gained muscle and strength, and increased physical activity .
The study, published in the journal Cachexia, Sarcopenia and Muscle, provides for the first time that BAM15, a mitochondrial decoupler, prevents sarcopenic obesity, or age-related muscle loss with concomitant increases in adipose tissue .
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Accidentally discovered that the lymphatic system can help the heart repair
Time of Update: 2022-04-15
Edward Thorp, associate professor of pathology in the Department of Experimental Pathology and one of the study's senior authors, said the finding solidifies the role of the lymphatic system in repair after a heart attack and has theoretical and practical therapeutic implications .
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The Chinese research group Nature issued a document: the first time to provide an accurate image of the activation state of STING
Time of Update: 2022-04-15
To answer this question, the Zhang and Bai labs mixed purified STING protein with cGAMP and imaged the results using cryo-electron microscopy (cryoo-EM) .
"This newly discovered STING-activated binding site was completely unexpected, and we called it the 'mystery pocket' because it appears to have formed in response to the presence of C53 .
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PLOS: The relationship between left brain asymmetry and reading ability
Time of Update: 2022-04-15
The new study used structural magnetic resonance imaging (MRI) of more than 700 children and adults, along with a reading test of pseudowords and a mathematical method called persistent homology, to test how brain asymmetry affects Two opposing theories of speech processing .
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Faster, cheaper test for Covid-19
Time of Update: 2022-04-15
"Currently, there are rapid antigen test kits on the market, but the biggest problem is still the high false-positive rate (about 60 percent)," said Yanjun Yang, a doctoral student in the University of Georgia School of Engineering and first author of the new paper.
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Nature: What makes brain cells develop in a specific order
Time of Update: 2022-04-15
"Understanding how the human brain develops will allow us to replicate these developmental processes in future laboratories, generating specific types of neurons in petri dishes and potentially transplanting them into patients, or in living organisms Trigger neural stem cells to generate and replace missing neurons ," said Claude Desplan, senior author of the study and Silver Professor of Biology at NYU .
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Aging Cell: Rejuvenating mouse organs through cellular reprogramming
Time of Update: 2022-04-15
Manuel Serrano, scientists from the IRB Cell Plasticity and Disease Laboratory in Barcelona have successfully reprogrammed a number of mouse organs and tissues to rejuvenate .
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A new target for colorectal cancer immunotherapy: B7H3/B7H4
Time of Update: 2022-04-15
Because myeloid cells express a functional calcineurin NFAT axis that can be activated by Toll-like receptor agonists, the researchers explored the role of this pathway in intestinal tumor development .
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Protective effect and mechanism of Gynostemma saponins on nervous system diseases
Time of Update: 2022-03-09
Studies have also shown that high levels of Aβ in the brain can activate microglia to secrete pro-inflammatory factors such as TNF-α, IL-1β, and IL-6, resulting in nerve cell damage and even death .
