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Rural or urban?
Time of Update: 2022-04-20
First, the scientists found that, on average, people who grew up in rural areas had a better sense of direction than those who grew up in cities .
So, according to their findings, growing up in a city with a complex topography gives a better sense of direction .
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Chinese scientists have made important progress in the analysis of the genetic basis of frog arboreal adaptation
Time of Update: 2022-04-20
Integrating morphological, behavioral, genomics, transcriptomics and other multi-dimensional research methods, the genetic mechanism of its climbing and gliding behavior-related phenotypes has been systematically analyzed, providing a new perspective for the study of the genetic mechanism of the evolution of animal adaptive complex traits .
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Nature Structural & Molecular Biology has made new progress in the field of Alzheimer's disease pathogenesis research
Time of Update: 2022-04-20
The research team found that the norepinephrine metabolite DOPEGAL in the locus coeruleus covalently modifies the K353 site of Tau protein, promoting Tau aggregation and disease dissemination .
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Yang Xiuwei's team has made progress in the research on the physiological function of metabolic enzymes
Time of Update: 2022-04-20
Gonzalez of the National Cancer Institute of the National Institutes of Health have collaborated to use a variety of transgenic mice and metabolomics, Transcriptomics and other research methods have discovered the mechanism of CYP2E1 metabolic enzymes that cooperate to regulate obesity by sharing substrates with nuclear receptor PPARα .
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Nat Com formyl peptide receptor structure brings new opportunities for Alzheimer's drug development
Time of Update: 2022-04-20
Comparing the complex structures of FPR1 and FPR2 with different formyl peptides, it was found that the difference in charge within the ligand-binding pockets of the two receptors and the openness of the extracellular regions of the receptors determine the ligand selectivity .
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Significantly improve symptoms in Parkinson's disease patients with new mechanism therapy Phase 2 clinical results are positive
Time of Update: 2022-04-20
▲NETSseq technology platform (Image source: Cerevance's official website)In this randomized, double-blind, placebo-controlled Phase 2 clinical trial, approximately 135 Parkinson's disease patients received two different doses of CVN424 .
References:[1] Cerevance Reports Positive Phase 2 Clinical Trial Results with CVN424, a Parkinson's Disease Drug Working Through a New Mechanism.
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PNAS: Classification of 16 Adult Sleep Patterns Based on Large-Scale Sleep Analysis
Time of Update: 2022-04-20
Using an algorithm they developed in 2022 (ACCEL), the research team generated sleep data for about 100,000 people based on acceleration data .
The obtained sleep data were transformed into 21 sleep indicators, and then dimensionality reduction (4) and clustering (5) methods were used to classify sleep patterns into 8 different clusters .
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Why doesn't fire kill some bacteria and fungi?
Time of Update: 2022-04-20
Future projects will not only focus on the characterization of post-fire microbes, but will also investigate whether adding pre-fire fungi and bacteria to the soil could aid recovery .
"Fires have strong effects on soil chemistry, and the main contributors to those effects are microbes," Glassman said .
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Westlake University's latest article: "Combination Boxing" Helps Efficient Synthesis of Natural Product daphenylline
Time of Update: 2022-04-20
. Different from the previous synthesis, Lu Haihua's team constructed a key seven-membered carbocyclic ring and a quaternary carbon-containing continuous chiral center by studying the intramolecular dearomatization reaction of naphthol derivative 13 , and then combined the long-range carboxylic acid-directed Mukaiyama-Michael Addition reaction ( MMR ) and tandem reductive amination / ammonolysis, complete the asymmetric synthesis of daphenylline ( 3 ) concisely and efficiently (Fig.
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"Science" New Ancient DNA Study Reveals 5,000 Years of Xinjiang's Population History
Time of Update: 2022-04-20
"Overall, the Bronze Age Xinjiang population was found to contain ancestral components of the 'native' Tarim Basin population, mixed to varying degrees with three groups from the surrounding area: Afanasievo, a The steppe culture associated with Indo-Europe, a group called Chemurchek, which contains BMAC ancestors from Central Asia, as well as ancestors from Northeast Asian populations, is called the last corresponding author of the paper, Professor Fu .
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Science sub-journal: Tumor repair mechanism may be a potential drug target
Time of Update: 2022-04-20
In their search for ways to prolong the survival benefit of targeted therapy, a team led by researchers at the Duke Cancer Institute has discovered a potential new strategy for disrupting the repair mechanisms that cancer cells use after treatment.
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Li Houhua's team made progress in the chemical synthesis of Hyperforin, the active ingredient of Hypericum perforatum
Time of Update: 2022-04-20
Recently, Houhua Li's team from the State Key Laboratory of Natural and Biomimetic Medicines, School of Pharmacy, Peking University, published the latest research results online in the internationally renowned journal " Angewandte Chemie International Edition ": " Enantioselective Total Synthesis of Hyperforin and Pyrohyperforin " .
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Shanghai Jiaotong University Dong Tao's team has made new progress in the study of the mechanism of environmental influence on bacterial competition
Time of Update: 2022-04-20
Recently, Dong Tao's team from the School of Life Science and Technology of Shanghai Jiao Tong University and the State Key Laboratory of Microbial Metabolism revealed that environmental factors determine the survival mechanism of bacteria in the competition mediated by the type VI protein secretion system (T6SS) .
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People's Hospital Li Zhanguo's research results on immunotherapy of rheumatoid arthritis published online
Time of Update: 2022-04-20
9" >In March 2022, the research results of the team of Professor Li Zhanguo from Peking University People's Hospital "Double-blind, randomized, controlled study of the efficacy and safety of low-dose IL-2 combined with methotrexate in the treatment of rheumatoid arthritis" (Efficacy and safety of Ld -IL2 in combination with MTX in patients with active RA: a randomized trial) was published online in the authoritative academic journal Signal Transduction and Targeted Therapy (STTT, IF 18.
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An ointment that shrinks oral tumors!
Time of Update: 2022-04-20
"Our findings suggest that miR-634-mediated inhibition of tumor-promoting factors can effectively increase the sensitivity of OSCC to existing chemotherapy regimens such as cisplatin," Tran said .
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Li Huabing and other teams published new results in Science Advance - revealing that m6A maintains intestinal epithelial cell homeostasis...
Time of Update: 2022-04-20
On March 26, the research team of Li Huabing from Shanghai Jiao Tong University School of Medicine-Shanghai Institute of Immunology published a paper entitled m 6 A mRNA modification maintains colonic epithelial cell homeostasis via NF-κB-mediated anti-apoptotic pathway in Science Advances .
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A student who didn't believe the professor's words found that optical targeting triggers apoptosis
Time of Update: 2022-04-20
Professor Sudo explained: "We believe that a breakthrough in cancer treatment could be achieved without side effects if a protein, rather than a chemical, could be used to quietly induce apoptosis in target cancer cells .
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Cough mouse model
Time of Update: 2022-04-20
Therefore, the Osaka University research team aimed to identify the mechanisms that control cough in order to facilitate the development of treatments for those with active disease .
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Male contraceptives: Discovery of natural compounds with 'ideal' contraceptive effects
Time of Update: 2022-04-20
The results of our non-harmful study in lower primates suggest that triptolide would also be an effective contraceptive for human males.
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"Nature Review" Application of CRISPR in Cancer Research, Diagnosis and Treatment
Time of Update: 2022-04-20
The impact of CRISPR on cancer biology researchCancer precision medicine strategies rely on the discovery of genetic mutations that promote cancer growth, and CRISPR gene editing technology can rapidly and efficiently generate gene knockouts that modulate endogenous gene expression and replicate cancer-related genomic changes .
