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New treatment for rare blood cancer
Time of Update: 2022-04-23
Gotlib advised Worthen to participate in a phase 1 clinical trial of a drug he leads called avapritinib, which works similarly to midostat but is unlikely to cause serious side effects because it only targets the KIT protein .
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Chinese scientists reveal treatment strategies for advanced prostate cancer
Time of Update: 2022-04-23
Taken together, the results of this study suggest that chickpea A inhibits 3bHSD1, thereby eliminating the tumorigenic effect of progesterone and inhibiting the development of prostate cancer .
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How cells control their boundaries
Time of Update: 2022-04-23
"So, by adjusting the saturation of fatty acids in the cell membrane and the type and amount of sterols, we can alter the permeability of yeast and bacterial cell plasma membranes .
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Hundreds of 'hidden' new mammal species await discovery
Time of Update: 2022-04-23
"Based on our analysis, a conservative estimate is that there are hundreds of species of mammals worldwide that have yet to be identified," Carstens said .
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For the first time, direct projections from TMN to MS histaminergic nerves have been found to bidirectionally regulate feeding behavior
Time of Update: 2022-04-23
Unexpectedly, this study is the first to find that the food-feeding inhibition induced by optogenetic activation of MS histaminergic nerve endings can be abrogated by H2 receptors, but not by H1 receptor antagonists, and in a case model, food-derived The levels of H2 receptors in MS glutamatergic neurons in obese mice were significantly reduced compared to those in normal-weight mice (Figure 1 ) .
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NAR breakthrough discovery: RNA's 'on' and 'off'
Time of Update: 2022-04-23
The new simulation model, affectionately known as R2D2 (short for "Reconstructing RNA Dynamics from Data"), trains RNA as it binds to compounds, communicates along its length and fold to turn genes on or off.
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Gene therapy gel holds promise for treating skin diseases
Time of Update: 2022-04-23
Mark HanlonIn a trial led by researchers at Stanford School of Medicine, a gene therapy gel was applied to the wounds of nine patients, three of whom were children, with the vesicular skin disease epidermolysis bullosa, Help wounds heal and keep them healed for several months .
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Antibody diversity decreases with age
Time of Update: 2022-04-23
A team of researchers led by Dario Ricardo Valenzano investigated whether the immune system of short-lived killifish ages .
"If different antibodies decrease with age, this could lead to a decrease in the ability to respond to infection .
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Scientists discover the body's natural alert to blood loss!
Time of Update: 2022-04-23
University of Virginia School of Medicine researchers Stephen Abbott (left to right), Daniel Stonetta and George Sousa discovered the body's natural alarm to blood loss .
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Shanghai Jiaotong University Cao Li's research group successfully analyzed the cryo-electron microscopy structure of TMEM106B fibers in the brain tissue of patients with frontotemporal lobar degeneration
Time of Update: 2022-04-23
The collaborative research results of Eisenberg's group and others have analyzed the high-resolution structure of amyloid fibers extracted from the brain tissue of patients with frontotemporal lobar degeneration, providing important information for the study of the pathological mechanism of the disease .
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Innovent Bispecific Antibody Therapy Targeting Claudin18.2 Enters Clinic
Time of Update: 2022-04-23
On March 29, Innovent Biopharmaceutical Group announced its self-developed recombinant bispecific antibody targeting claudin 18.
This study is an open-label, multicenter Phase 1a/1b study evaluating the safety, tolerability, and efficacy of IBI389 in the treatment of advanced malignancies.
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Unraveling the immune complexities of SARS-CoV-2, HIV and pneumonia
Time of Update: 2022-04-23
At 10x Genomics' Global Symposium on Infectious Diseases, several leading scientists shared their latest findings, providing insight into how they are using innovative single-cell technologies to advance our understanding of the immune response after infection .
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Salivary immune signature of SARS-CoV-2 infection—different from other influenza-like illnesses
Time of Update: 2022-04-23
The researchers concluded that identifying inflammatory markers in patients with COVID-19 that differs from other influenza-like illnesses suggests a unique immune signature associated with the disease .
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Paving the way for triple-negative breast cancer treatment
Time of Update: 2022-04-23
Recently, Spector, postdoctoral researcher Sonam Bhatia, and collaborators from CSHL and Northwell Health created a biobank of 87 triple-negative breast cancer organoids .
The research team, which plans to expand the biobank to more than 100 samples from patients, conducted extensive testing to ensure that the organoids had the same tumor characteristics in patients .
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Researchers identify key complex for ribosome production
Time of Update: 2022-04-23
Buszczak said the basic principles of this process are the same as the biological production of human ribosomes, but the specifics are different .
Using the tool on several different human cell types, the researchers identified different rates of ribosome production in each cell .
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Academician Huang Ru of the Brain-inspired Intelligent Chip Research Center—Assistant Professor Yan Bonan's research group has taken the...
Time of Update: 2022-04-23
At this meeting, academician Huang Ru from Peking University School of Integrated Circuits and Institute of Artificial Intelligence - Assistant Professor Yan Bonan's research group published an academic article on in- memory computing " A 1.
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Shanghai Jiaotong University Liu Yu's research group developed a new RNA site-specific labeling method
Time of Update: 2022-04-23
"Labeling of RNA at Specific Positions" research paper, developed a new method of RNA co-transcription-site-specific labeling, SMRITI (site-specific modification of RNA via initiation-escaped transcription) .
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Jiahe Biotech EGFR/c-Met/c-Met trispecific antibody applied for clinical application
Time of Update: 2022-04-23
Article source: Medical Cube InfoOn March 29, CDE's official website showed that Jiahe Bio's application for clinical trials of EGFR/c-Met/c-Met trispecific antibodies in China was accepted by the State Food and Drug Administration .
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BIOPIC Zhang Zemin/Ren Xianwen's research group and collaborators analyze the potential influencing factors of tumor microenvironment formation
Time of Update: 2022-04-22
Unlike cross-cancer analysis, the tumor metastasis process provides researchers with a unique system to unravel the effects of niche and malignancy on TME, since metastatic tumors originate from the same individual's primary tumor, collecting different tumor sites from patients with metastases can Help researchers to parse the TME formed by tumor cells of the same origin in different organs .
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Study shows long-term safety of genetically modified immune effector cells
Time of Update: 2022-04-22
A new study by researchers at the Center for Cell and Gene Therapy at Baylor College of Medicine shows that patients receiving genetically modified immune cells ( IECs)-treated cancer patients did not have an increased risk of subsequent malignancies .
