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Structural basis for autoinhibition of the human NHE3-CHP1 complex
Time of Update: 2022-08-11
IntroductionNot applicable+/H+Exchange or anti-transporters (NHEs/NHAs) are integral membrane secondary active transporters present in all organisms examined to date, a notion that supports their origin in an early stage of biosphere evolution (1).
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High-fiber diet may reduce dementia risk
Time of Update: 2022-08-11
Researchers at the University of Tsukuba in Japan have found that high levels of dietary fiber, especially soluble fiber, are associated with a lower risk of dementia .
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Focus on lupus to explore how to predict disease onset in systemic lupus erythematosus
Time of Update: 2022-08-11
In a recent study, Dr. John Tsang, co-director of the NIH Center for Human Immunology (CHI), and his team built on previous work to use SLE as a model to study vaccine responses to healthy populations and disease activity in SLE Sex-related common baseline gene expression signatures .
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Huazhong University of Science and Technology's Nature sub-published article: A novel high-efficiency CT contrast agent based on conjugated polymers facilitates precise diagnosis and treatment of tumors
Time of Update: 2022-08-11
(Correspondent Yin Mingming) On May 12 , the team of Professor Luo Liang from the National Nanomedicine Engineering Technology Research Center, School of Life Science and Technology, Huazhong University of Science and Technology, developed a conjugated polymer material with an iodine content of up to 84% , which can be used for CT comparison High-efficiency CT imaging can be used to guide precise surgical resection and stereotactic radiotherapy of tumors .
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Review: Stem cell technology to reverse premature ovarian failure
Time of Update: 2022-08-11
Intraovarian injection of autologous human mesenchymal stem cells increases estrogen production and reduces menopausal symptoms in women with premature ovarian failure: two case reports and a review of the literature.
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Chen Suren's research group published an article in Development to reveal the role of ACTRT1 in sperm development and function
Time of Update: 2022-08-11
The research of Chen Suren's group first revealed ACTRT1 is one of the ARP proteins specifically expressed in the subacrosomal plate of sperm , and colocalizes and interacts with ACTL7A and ACTL9 .
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For the first time, corneal T cells that protect the eye from viral infections have been discovered
Time of Update: 2022-08-11
. The study, published today in Cell Reports, shows that long-lived memory T cells that patrol and fight viral infection are present in the cornea, overturning the current belief that there are no T cells in healthy corneas and expanding our understanding of An understanding of the eye's immune response to infection .
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Chinese scholars have made progress in asymmetric free radical cross-coupling
Time of Update: 2022-08-11
Figure (A) Chiral control mode of radical species; (B) Design of chiral ligands based on reaction mechanism; (C) Precise construction of chiral quaternary carbon molecular building blocks Under the support of the National Natural Science Foundation of China (Grant No.
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Follow-up Interview·Academician Special Dialogue with Bao Zhenan and Ming Guoli, Looking into Artificial Skin and Brain Organoids
Time of Update: 2022-08-11
Professor Ming Guoli of Mann School of Medicine In the next "Follow-up Interview", we will have the honor to talk to Prof.
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Science: What controls when and where rivers turn suddenly
Time of Update: 2022-08-11
The findings reveal how rupturing may respond to climate and land-use changes -- exposing upstream communities to floods they've never experienced before -- and they provide a framework to help predict when and where future rupturing may occur .
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Central memory T cells are the most potent precursors of resident memory T cells in human skin
Time of Update: 2022-08-11
. effector memory T cells (TRelative length unit) has the highest conversion rateRinggitin vitro and in vivo, but central memory T cells (Tcentimeter) lasts longer in the cycle, enters the skin in greater quantities, and produces more TRinggitAll in all, Tcentimeteris a highly efficient precursor to human skinRinggit, a feature that may underlie their known association with effective long-term immunity .
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Salmonella induces a cGAS-STING-dependent type I interferon response in mouse macrophages by triggering mtDNA release
Time of Update: 2022-08-11
. In this study, we report that in addition to TLR4-dependent responses, the cytosolic surveillance pathway (CSP) cGAS STING is also required to activate type I IFN responsesUnited States .
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Synaptic connections of new cell populations in the striatum
Time of Update: 2022-08-11
Future steps in this area of research will be to study this population in more detail, including its relationship to striatal function and dysfunction GABAergic interneurons expressing α2 nicotinic receptor subunits are functionally integrated in striatal microcircuits .
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Targeting immune cell-neuron crosstalk restores youthfulness to aging neurons
Time of Update: 2022-08-11
(1) Lymphotoxin beta activates NF-κB;(2) Phosphorylation of NF-κB increases the expression of CXCL13;(3) CXCR5 type+CD8+T cells enter the DRG parenchyma;(4,5) Sciatic axonal injury activates the injury signal;(6) MHC I is presented by DRG neurons;(7) CXCR5 type+CD8+T cells bind to MHC I and activate neuronal caspase3;(8) Cleaved caspase3 reduces pAKT and pS6, resulting in regeneration failure .
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Oral version of drug protects against SARS-CoV-2 in mice
Time of Update: 2022-08-11
SummaryDespite the rapid introduction of a safe and effective vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the COVID-19 pandemic remains uncontrollable, underscoring the need for the development of highly effective antiviral drugs .
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JAMA: Omicron causes more excess deaths in Massachusetts than Delta
Time of Update: 2022-08-11
S. population at the time Hanage also said that compared to Delta and other variants, Omicron appeared to be more "mild", possibly due to the higher immunity of the U.
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New research center at MIT: The relationship between the brain and the body
Time of Update: 2022-08-11
Center's GoalsThe center's initial projects will focus on four research directions:Gut-brain: Anikeeva's team will expand the toolbox of new technologies and apply these tools to study major neurobiological questions, the gut-brain in the context of autism spectrum disorders, Parkinson's and affective disorders Brain pathways and connections .
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Yao Zhirong/Li Ming/Zhang Si team discovered a new disease-CAOP syndrome causative gene MBTPS1 and its pathogenic mechanism
Time of Update: 2022-08-11
After more than ten years of research, the team of Yao Zhirong/Li Ming/Zhang Si from Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine reported for the first time that membrane-bound transcription factor peptidase/site 1 protease (MBTPS1/S1P) is the causative gene of CAOP syndrome.
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Important progress has been made in the analysis and control of fungal infection of Haematococcus pluvialis by the Aquatic Institute
Time of Update: 2022-08-11
A schematic diagram of the mechanism of action of secondary metabolites in promoting fungal infection of Haematococcus pluvialis Haematococcus pluvialis is a unicellular green alga with high application value because it can accumulate more than 5% of the dry cell weight of astaxanthin under induced conditions .
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Zhang Jie's group from Shanghai Jiaotong University and their collaborators published the latest research results on the marginal criticality of particulate matter in PNAS
Time of Update: 2022-08-11
On May 24, 2022, Professor Zhang Jie's research group from the Institute of Natural Sciences, School of Physics and Astronomy, Shanghai Jiao Tong University, in collaboration with researcher Jin Yuliang from the Institute of Theoretical Physics, Chinese Academy of Sciences, published a paper entitled " Experimental observations " in the Proceedings of the National Academy of Sciences (PNAS).
