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The treatment of diffuse tenosynovial giant cell tumor is in urgent need of innovative therapy and the breakthrough therapy ABSK021 is expected to break the gap
Time of Update: 2022-08-19
As an example, Associate Professor Zhou Yong said, "There was a patient with recurrent giant cell tumor of the tendon sheath in the knee joint.
As an example, Associate Professor Zhou Yong said, "There was a patient with recurrent giant cell tumor of the tendon sheath in the knee joint.
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Scientific Reports: Rhodiola Root May Benefit Type 2 Diabetes
Time of Update: 2022-08-19
The study, recently published online in Scientific Reports, found that in a mouse model of human type 2 diabetes, Rhodiola reduced fasting blood glucose levels, improved response to insulin injections, and modulated gastric composition of gut bacteria and decreased several biomarkers of inflammation .
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Nature Biotechnology: a high-fidelity Cas13 system with higher specificity and better safety
Time of Update: 2022-08-19
article titleHigh-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effects Figure: Design, screening, and description-engineered high-fidelity Cas13 variants A new study has revealed that through mutation, the development of high-fidelity Cas13 variants significantly reduces collateral effects .
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A review clarifies genotype-independent plant transformation
Time of Update: 2022-08-19
This article reviews recent advances in the application of regulatory genes in plant transformation and regeneration, and their potential to facilitate genotype-independent plant transformation and regeneration .
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PNAS: Immune cells in the gut love sweets
Time of Update: 2022-08-19
Tissue-resident white blood cells use glucose as an energy source to fight infection, new study finds A new study, led by Associate Professor Marc Veldhoen of the Faculty of Medicine of Lisbon (FMUL)
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Post-80s Ph.D. supervisor joins hands with Chengdu's "strongest computing power" to develop new drugs for the treatment of Alzheimer's
Time of Update: 2022-08-19
West China Metropolis Daily - Cover reporter Liu Qiufeng When the "strongest brain" meets the "strongest computing power", what kind of sparks will collide?As a post-80s doctoral tutor at West China Clinical School of Medicine, Sichuan University, Tian Xiaohe's team is working on Alzheimer's disease research .
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Nature Genetics: Skin-derived stem cells suffer from massive DNA damage
Time of Update: 2022-08-19
However, researchers at the University of Cambridge and the Wellcome Sanger Institute have found a problem with induced pluripotent stem cells generated from skin cells and blood .
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Liu Wenxian's group published a paper in CMI, revealing the important mechanism of Myc inhibitor exerting new functions in anti-tumor immune response
Time of Update: 2022-08-19
This study focused on the function of the proto-oncogene Myc in anti-tumor immune responses, and demonstrated for the first time that the sensitivity of different T cell subsets to Myc inhibitors in the tumor microenvironment is determined by the expression of Myc protein.
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The latest paper from Xiamen University: A new method for prediction of transcriptional activation elements in rice
Time of Update: 2022-08-19
The team of researchers developed a new method using flow cytometry fluorescence sorting technology (FACS) combined with STARR-seq, which significantly improved the accuracy of rice transcription activation element prediction, and provided a basis for the study of the biological function of plant enhancers.
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Oncogene: sugar chains on cell surface guide cancer cell death
Time of Update: 2022-08-19
article titleLewis glycosphingolipids as critical determinants of TRAIL sensitivity in cancer cells Figure: Cancer cells highly expressing Lewis glycans on glycolipids are vulnerable to the death-inducing cytokine TRAIL .
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Nature sub-journal: A new method to make metastatic cancer detection easier and faster
Time of Update: 2022-08-19
"Analysis of patient tumor cell clusters The researchers, in collaboration with Emory Hospital and Northside Hospital, used the chip to screen blood samples from patients with ovarian or prostate cancer .
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Sci Rep: What happens to genes in arterial plaque that triggers stroke?
Time of Update: 2022-08-19
Researchers at Ochsner Health and Tulane University School of Medicine have identified genes that become active in the carotid arteries when plaque ruptures leading to stroke .
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Nature sub-journal: Roadmap for immune defense cells
Time of Update: 2022-08-19
Image credit: Christoph Thomas & Robert Tampé, Goethe University Frankfurt, Germany Figure: The fully assembled PLC antigen processing machinery consists of the antigen transport complex TAP1/2, the chaperones calreticulin, ERp57 and tapasin, and the heterodimeric MHC I (heavy and light chains, cyan and green, respectively) .
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Accurate regulation of transgene expression in arterial endothelial cells in vivo by ultrasound-guided method for the first time
Time of Update: 2022-08-19
Zhifei Dai's team has established a new method for the controllable expression of exogenous genes in specific regions of the arterial endothelium through ultrasound image guidance .
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"Immunity" "eat less" to prevent aging process-related proteins
Time of Update: 2022-08-19
In a new study, researchers at Yale University show that moderate calorie restriction can reduce the production of a protein called SPARC, which can control harmful inflammation and improve health in older adults .
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Gene inhibitor helps slow blood clots in COVID-19 patients
Time of Update: 2022-08-19
Additional ongoing studies are elucidating the mechanisms that mediate the increased expression of TYMP by the SARS-CoV-2 spike protein, and the potential impact of TYMP in prolonged COVID-19 .
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New progress of Brassica chinensis gene editing system: optimal fixation method, optimal probe length and concentration for in situ hybridization
Time of Update: 2022-08-19
The result was published in Plant Methods under the title "Establishment and optimization of mRNA in situ hybridization system in turnip (Brassica rapa var.
The result was published in Plant Methods under the title "Establishment and optimization of mRNA in situ hybridization system in turnip (Brassica rapa var.
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Scientists discover new role of blood-brain barrier in neuronal function and damage
Time of Update: 2022-08-19
article titleDelta/Notch signaling in glia maintains motor nerve barrier function and synaptic transmission by controlling matrix metalloproteinase expression The role of the blood-brain barrier has long been appreciated because of its precise control over the molecules that enter the nervous system, but little is known about how the cells that form the blood-brain barrier affect the functioning of the nervous system .
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A new perspective on immune fine-tuning through 'mechanics'
Time of Update: 2022-08-19
Recognizing that physical forces originating at the tissue level influence the activation and function of immune cells may provide new insights into the treatment of a wide range of diseases .
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Princeton University develops simple pleural protein synthesis technique
Time of Update: 2022-08-19
The laboratory reports the facile synthesis of the pleural protein cis-hydrindane to the desired trans-hydrindane by means of the Diels-Alder reaction and free radical enantiomerization .
The laboratory reports the facile synthesis of the pleural protein cis-hydrindane to the desired trans-hydrindane by means of the Diels-Alder reaction and free radical enantiomerization .
