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Brain cleaners reprogramming to clear Alzheimer's disease
Time of Update: 2022-08-19
Although changes in these cells are known to play an important role in Alzheimer's and other brain disorders, said Martin Kampmann, PhD, senior author of the study, published Aug. 11 in the journal Nature Neuroscience.
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The Altitude Gradient Pattern and Construction Mechanism of Amphibian β Diversity in Mount Emei Revealed by Chengdu Institute of Biology
Time of Update: 2022-08-19
In order to deeply understand the amphibian diversity of Mount Emei and its construction mechanism, the team of researcher Hu Junhua from Chengdu Institute of Biology, Chinese Academy of Sciences analyzed the different dimensions of amphibians (species, species, Phylogenetic and functional) β diversity and the distribution pattern of different components (turnover and nesting) along the altitude gradient, revealing the influence of altitude and environmental factors (temperature, rainfall, solar radiation and normalized vegetation index, etc.
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Insect chemical ecology team makes new progress in heavy metal pollution affecting insect smell
Time of Update: 2022-08-19
2c03108 Nanhu News (Correspondent Yang Fuxiang) Recently, Professor Wang Manyu from the School of Plant Science and Technology of our school led the insect chemical ecology team to publish a research paper entitled "Sublethal Exposure to Cadmium Induces Chemosensory Dysfunction in Fire Ants" in "Environmental Science & Technology" .
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Targeting lymphatic system, cancer vaccine eliminates and prevents tumor recurrence
Time of Update: 2022-08-19
"Lipid nanoparticle-mediated lymph node–targeting delivery of mRNA cancer vaccine elicits robust CD8+ T cell response Three T cells (red) attack a cancer cell (blue) For years, researchers around the world have been working to develop vaccines against different types of cancer, with little success .
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Is blood transfusion safe? AI holographic system detects blood quality without injection
Time of Update: 2022-08-19
□The research group of Professor Wen Renkui (Principal Guoyang) of the Department of Robotic Mechatronics Engineering at DGIST has developed an AI holographic imaging system that can automatically extract important information and check the quality of red blood cells .
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Nature Aging: Aging hearts accumulate mutations and lose ability to repair them
Time of Update: 2022-08-19
Over time, the cells that make up our heart muscle accumulate new genetic mutations while losing the ability to repair them, according to an unprecedented study from Boston Children's Hospital .
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Epigenetic discovery, HIV accelerates human aging
Time of Update: 2022-08-19
Reference: Accelerated aging with HIV begins at the time of initial HIV infection Changes at the DNA level can accelerate aging by about five years, according to a UCLA-led study .
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Should parents delay their child's second dose of the coronavirus vaccine?
Time of Update: 2022-08-19
It's time to build defensesEarlier this year, New York City-based Pfizer and Mainz, Germany-based BioNTech reported in a preliminary trial that a two-dose mRNA vaccine was less than 50% effective against symptomatic disease in children 6 months to 4 years old % .
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The treatment of diffuse tenosynovial giant cell tumor is in urgent need of innovative therapy and the breakthrough therapy ABSK021 is expected to break the gap
Time of Update: 2022-08-19
As an example, Associate Professor Zhou Yong said, "There was a patient with recurrent giant cell tumor of the tendon sheath in the knee joint.
As an example, Associate Professor Zhou Yong said, "There was a patient with recurrent giant cell tumor of the tendon sheath in the knee joint.
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Scientific Reports: Rhodiola Root May Benefit Type 2 Diabetes
Time of Update: 2022-08-19
The study, recently published online in Scientific Reports, found that in a mouse model of human type 2 diabetes, Rhodiola reduced fasting blood glucose levels, improved response to insulin injections, and modulated gastric composition of gut bacteria and decreased several biomarkers of inflammation .
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NSMB Shanghai Institute of Materia Medica Reveals the Molecular Mechanism of Orphan Receptor GPR119 Recognizing Ligands
Time of Update: 2022-08-19
Xie Xin of Shanghai Institute of Materia Medica , Chinese Academy of Sciences, together with Jiang YiNature Structural & Molecular Biology To study the structure of GPR119, the researchers expressed and purified a complex sample of the human GPR119 receptor and Gs protein trimer from insect cells, and resolved the complexation of GPR119 and Gs protein without adding small molecule ligands.
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A novel mechanism by which circSV2b is involved in the regulation of oxidative stress in Parkinson's disease through the miR-5107-5p-Foxk1-Akt1 axis
Time of Update: 2022-08-19
Weiguang Zhang from Peking University School of Basic Medicine published an online article entitled "CircSV2b participates in oxidative stress regulation through miR-5107-5p-Foxk1-Akt1 axis" in the authoritative journal Redox Biology in the field of biochemistry and molecular biology.
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Nature Biotechnology: a high-fidelity Cas13 system with higher specificity and better safety
Time of Update: 2022-08-19
article titleHigh-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effects Figure: Design, screening, and description-engineered high-fidelity Cas13 variants A new study has revealed that through mutation, the development of high-fidelity Cas13 variants significantly reduces collateral effects .
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New DNA repair method successfully repairs disease-causing gene mutation in patient's kidney cells
Time of Update: 2022-08-19
By applying synthetic biology techniques, a research team led by Dr Francesco Aulicino and Professor Imre Berger from the University of Bristol's School of Biochemistry has redesigned the baculovirus, an insect virus that is harmless to humans and no longer limited in "cargo" capacity .
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Cell Rep: Reconstructing real-time gene expression patterns from single-cell RNAseq datasets
Time of Update: 2022-08-19
article titleA guiding role of the Arabidopsis circadian clock in cell differentiation revealed by time-series single-cell RNA sequencing Figure: In the proposed model, BES1 rearranges the circadian clock by repressing LHY expression in meristem cells, resulting in a rephase and reconstruction of the clock with dynamic changes in the expression of clock genes .
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Study sheds light on problems with fracture healing in people with Down syndrome
Time of Update: 2022-08-19
The recently published study, led by Kirby Sherman, a doctoral student in the VMBS Department of Veterinary Physiology and Pharmacology (VTPP), not only illuminates a previously unknown problem, but also highlights the need for physicians to better address fracture healing in patients with DS .
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Breaking the century-old theory, the glucose metabolism of cancer cells is not abnormal
Time of Update: 2022-08-19
Corresponding author Professor Gary Patti of Washington University School of Medicine in St. Louis said: "In order to extract significant amounts of energy from glucose, cells must transport the products of its conversion to mitochondria .
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Deng Hongyu's research group and collaborators revealed that VMP1 and TMEM41B are DMV formation during betacoronavirus infection...
Time of Update: 2022-08-19
The betacoronavirus family belongs to positive-sense single-stranded RNA viruses, including SARS-CoV-2, SARS-CoV, and MERS-CoV . After βcoronavirus invades host cells, its genomic RNA is translated i
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A new study redefines age-accelerating 'zombie cells'
Time of Update: 2022-08-19
Reference: Telomeric 8-oxo-guanine drives rapid premature senescence in the absence of telomere shortening Researchers have discovered a new pathway by which 'zombie cells' that promote aging accumulate .
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Fighting Malaria with Mathematical Models
Time of Update: 2022-08-19
Professor Barnes said: "This timely evidence on the extent of SP resistance across Africa will help to understand where SP prophylaxis, alone or in combination with other antimalarial drugs, is most likely to have the greatest impact .
