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PNAS: How liver cancer hijacks the circadian clock mechanism within cells
Time of Update: 2023-02-02
Now, a study led by researchers at the Keck School of Medicine of USC not only directly links clock proteins to liver cancer, but also shows precisely how cancer cells hijack the clock mechanism to divide and spread.
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JAMA sub-issue: Ultra-processed food hurts the brain! A prospective cohort study followed for 8 years showed that a high intake of ultra-processed foods was associated with a 28% increase in the rate of cognitive decline
Time of Update: 2023-02-02
The researchers analyzed data from 10,775 civil servants in 6 cities in Brazil and followed up for about 8 years and found that the overall rate of cognitive decline in the group with higher UPF intake was significantly increased by 28% compared with those with UPFs intake in the first quartile (β=-0.
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The research group of Jiao Yuling in the School of Life Sciences cooperated to explain how auxin regulates leaf flattening
Time of Update: 2023-02-02
2215569119), combining experimental observations and computer simulations, revealed that auxin polar transport derived from stem tip meristem can form signal highs on both sides of the leaf primordium, activate the expression of the key gene SlLAM1 in leaf flattening at the leaf margin, and promote the establishment of symmetrical morphology on both sides of the leaf primordium.
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Toxoplasmosis: a pathogen with a molecular master key
Time of Update: 2023-02-02
The scientists believe that Toxoplasma gondii's wide host range suggests that the parasite can recognize multiple structures in host cells, thereby activating a central invasion complex.
The scientists believe that Toxoplasma gondii's wide host range suggests that the parasite can recognize multiple structures in host cells, thereby activating a central invasion complex.
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A series of new advances have been made in the study of the effects of roads in Chengdu on the taxonomy, functional and phylogenetic diversity of mountain plants
Time of Update: 2023-02-02
The project team of land surface processes and ecosystem management in the field of biodiversity and ecosystem services of the Chengdu Institute of Biology, Chinese Academy of Sciences, used systematic sampling method to investigate plant communities in the wild, compared the three-dimensional plant diversity of roadside and internal communities at the landscape scale, and analyzed the effect difference of road in three-dimensional plant diversity and the causal relationship between three-dimensional beta diversity in the background of road disturbance.
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GKC helps! The team from Zhengzhou University designed aptamers for the treatment of esophageal squamous cell carcinoma and confirmed that the molecular target was integrated β1
Time of Update: 2023-02-02
In this study, the research team screened out aptamers that can specifically identify ESCC cell lines through Cell-SELEX technology, and proved through tissue imaging that aptamer A2 can identify esophageal squamous cell carcinoma tissue, and the team also identified the aptamer-bound target as integratin β1 through pull-down, mass spectrometry experiments (technical services provided by GK) and siRNA interference technology.
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9 million people develop diabetes, which is strongly associated with this risk factor!
Time of Update: 2023-02-02
The researchers found that levels of outdoor artificial light exposure at night were positively correlated with impaired glycemic regulation, elevated blood sugar, and increased diabetes risk, with a 7% increased risk of diabetes for every 1 percentile increase in outdoor artificial light exposure.
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Scientists have found that the new coronavirus S protein induces long-term transcriptional inhibition of myocardial mitochondrial metabolism genes and leads to impaired myocardial fibrosis and contractile function
Time of Update: 2023-02-02
Overall, this study by Wenbin Tan's team shows that LDL-c can enhance the ability of viruses to enter cells, and that high-fat diet-induced obesity can lead to selective accumulation of viruses in heart, aorta, and adipose tissue; Subsequently, the S protein of the virus causes long-term transcriptional inhibition of the mitochondrial respiratory chain gene family, resulting in abnormal myocardial metabolism; Finally, myocardial fibrosis increases, and function is impaired.
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Professor Shi Jie's team revealed the neural circuit mechanism of compulsive drug-seeking behavior in drug addiction
Time of Update: 2023-02-02
Recently, Professor Shi Jie's team from the China Institute of Drug Dependence of Peking University published an online report entitled "An orbitofrontal cortex-anterior insular cortex" in the international important journal Science Advances circuit gates compulsive cocaine use", which first reported the role of the OFC-aIC neural circuit in compulsive drug-seeking behavior plays an important regulatory role.
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How to make the brain better maintain memory?
Time of Update: 2023-02-02
”A collaborative study conducted by Barnett and researchers at the University of California, Davis found that increased activity of the hippocampus at the boundary of an event may play a key role in better identifying when people with memory impairment are having difficulty.
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Deng Hongkui's research group established a new islet transplantation strategy to solve the key problems of stem cell treatment for diabetes
Time of Update: 2023-02-02
On January 9, 2023, Deng Hongkui's research group from the School of Basic Medical Sciences of Peking University Health Science Center and Peng Xiaozhong's research group from the Chinese Academy of Medical Sciences/Peking Union Medical College collaborated on Nature Metabolism Published a research paper entitled Implantation underneath the abdominal anterior rectus sheath enables effective and functional engraftment of stem cell-derived islets.
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Lost in translation: how "dangerous" amino acids abort the extension of protein synthesis
Time of Update: 2023-02-02
The team found that, similar to bacteria, the enrichment of nascent peptide chains of aspartate (D) or glutamate (E) in the N-terminal region of yeast cells led to the translation of IRD in yeast cells that miscarried.
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The Class I new drug CS0159 was granted fast-track status by the US FDA
Time of Update: 2023-02-02
(Contributing department: Xu Huaqiang research group) Recently, the new FXR agonist CS0159 jointly developed by the Xu Huaqiang team and Li Jia's team of Shanghai Institute of Materia Medica, has been recognized by the US Food and Drug Administration (FDA) Fast Track and is intended to be used to treat patients with nonalcoholic steatohepatitis (NASH).
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Surprising! Far from being an ordered process, organelle growth is random burst growth
Time of Update: 2023-02-02
Mukherji said: "The pattern of organelle size robustness is the same for budding yeast and human iPS cells.
Mukherji said: "The pattern of organelle size robustness is the same for budding yeast and human iPS cells.
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Women who have three children have a 50% lower risk of uterine cancer
Time of Update: 2023-02-02
In their study, researchers at the University of Queensland used genetic analysis to examine the year a woman ovulated, which was calculated by subtracting the time it took to become pregnant or take birth control pills from menstrual time.
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The researchers discovered key codon repeats that regulate cold tolerance in rice
Time of Update: 2023-02-02
Crops need to have excellent tolerance modules to cope with abnormal temperatures caused by global climate change, and variety design needs to rely on the principle of cell cold sensing defense "sign
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Nature's new target appears to prevent 90% of cancer deaths
Time of Update: 2023-02-02
An international team of researchers has discovered a potential new target for a drug that could prevent deadly metastases, which cause 90 percent of cancer deaths.
An international team of researchers has discovered a potential new target for a drug that could prevent deadly metastases, which cause 90 percent of cancer deaths.
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New oral drug lowers cholesterol by 70%
Time of Update: 2023-02-02
”Study resultsAt the heart of cholesterol regulation are LDL receptors, which sit on the surface of liver cells and remove cholesterol from the blood, thereby lowering serum levels.
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Science: The source of the left and right asymmetry of the human body - cilia
Time of Update: 2023-02-02
Using these tools, the researchers found that cilia are mechanical sensors on the cell surface that are important for left-right asymmetry in developing bodies and organs, such as the heart.
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A soft, stimulating scaffold supports brain cell development outside the body
Time of Update: 2023-02-02
It can be used not only to study the formation of human neural networks in vitro, but also to create implantable biohybrid BCIs that bind more seamlessly to a patient's brain tissue, improving its performance and reducing the risk of injury," said first author Christina Tringides, PhD, a former graduate student at Wyss and SEAS and now a postdoctoral researcher at ETH Zürich.
