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New discovery: A small molecule can cause amyloid tangles in Alzheimer's disease
Time of Update: 2022-10-01
Using a molecule found in green tea, UCLA scientists have discovered other molecules that break down protein tangles in the brain that are thought to cause Alzheimer's disease and similar diseases.
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Professor Liu Wen's team discovered the key regulatory mechanism of super enhancers in breast cancer and the corresponding targeted intervention...
Time of Update: 2022-10-01
Recently, the team of Professor Liu Wen of the State Key Laboratory of Cell Stress Biology, Fujian Provincial Key Laboratory of Drug New Target Research, and School of Pharmacy has discovered the epig
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The mechanism behind virus-induced inflammation of the heart
Time of Update: 2022-10-01
Viral Proteases Activate the CARD8 Inflammasome in the Human Cardiovascular System A virus that attacks heart tissue causes severe damage by triggering an inflammatory response that ultimately leads to cell death.
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The potential of precise genome editing in the treatment of hereditary retinal diseases
Time of Update: 2022-10-01
This paper describes current preclinical success and clinical genome editing approaches to the treatment of hereditary retinal degenerative diseases, and highlights the promise that gene editing in living organisms will be the therapeutic paradigm for IRDs in the future.
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Viruses "watch" the "weapons" of the host
Time of Update: 2022-10-01
Eavesdropping on the communication system of cellsInstead of using their own proteins to gather information, some bacteriophages use the infected cell's own DNA damage sensor: LexA.
Eavesdropping on the communication system of cellsInstead of using their own proteins to gather information, some bacteriophages use the infected cell's own DNA damage sensor: LexA.
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PNAS scientists have discovered a new function of a protein – fighting bone loss
Time of Update: 2022-10-01
The study first linked IFT80 to the role of osteoclasts and found that IFT80 controls a protein degradation pathway that acts as a negative regulator during osteoclast differentiation.
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Blood sugar control can reverse diabetes-related brain damage
Time of Update: 2022-10-01
A Pilot randomized trial to examine effects of a hybrid closed-loop insulin delivery system on neurodevelopmental and cognitive outcomes in adolescents with type 1 diabetes The new study shows that the brain damage that type 1 diabetes causes to adolescents is reversible.
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Scientists have discovered a unique breast cancer cell that controls the ability to proliferate and colonize the lungs
Time of Update: 2022-10-01
According to a study published in Cell Report in September, scientists from the Tisch Cancer Institute have discovered a mechanism by which certain breast cancer cells regulate their own metastasis, spread from the original tumor site, and decide to invade distant organs, such as the lungs.
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Diabetes's new hypothesis for type 1 diabetes: T1D is preventable
Time of Update: 2022-10-01
According to Corkey, her research led her to propose a verifiable hypothesis that autoimmune induction is the result of one or more major inflammatory events in individuals with phenotypes of susceptible human leukocyte antigens (molecules found on the surface of most cells in the human body that play an important role in the body's immune response to foreign substances), plus a high sensitivity to cytokines (substances secreted by certain cells of the immune system) and free fatty acids (FFA).
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Science discovers the secret of the formation of intestinal organs
Time of Update: 2022-10-01
essayPitx2 patterns an accelerator-brake mechanical feedback through latent TGFb to rotate the gut Our internal organs and all organs are arranged in a left-right asymmetrical pattern in the body so that everything fits.
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Liu Bo's research group published a research paper in Cell Reports, revealing a regulation of fruit fly resistance...
Time of Update: 2022-10-01
This study revealed that the tumor suppressor dRASSF is involved in the regulation of the antiviral immune response of Drosophila by modulating the Imd signaling pathway and then regulating the activity of the JAK/STAT signaling pathway.
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Science Advances: Breeding mosquitoes that can't transmit malaria
Time of Update: 2022-10-01
essayGene drive mosquitoes can aid malaria elimination by retarding Plasmodium sporogonic development Professor George Christophides holds a cage of mosquitoes Scientists genetically engineered mosquitoes to slow the growth of malaria-causing parasites in their guts, preventing malaria from spreading to humans.
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Yuan Jing's research group published a research paper in eLife, revealing the molecules of Plasmodium cell morphology control...
Time of Update: 2022-10-01
org/articles/77447#content On July 18, Yuan Jing's research group published a research paper titled Inner membrane complex proteomics reveals a palmitoylation regulation critical for intraerythrocytic development of malaria parasite in the journal eLife.
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Chinese scholars have successfully developed the current minimum low-power phase change memory unit
Time of Update: 2022-10-01
(a) Schematic diagram of the measurement settings; (b) Cycle life of ~3 nm wide GNR boundary electrode phase change memory unit at different voltage polarities Figure 3 Demonstration of D-type trigger logic function based on 3 nm wide GNR boundary electrode.
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The cause of liver fibrosis is found!
Time of Update: 2022-10-01
Biliary NIK promotes ductular reaction and liver injury and fibrosis in mice The liver is the most important organ responsible for processing everything we ingest, from food and drink to alcohol and drugs.
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The new study explains the link between diabetes and urinary tract infections
Time of Update: 2022-10-01
Researchers at the Karolinska institute in Sweden have now found that people with diabetes have lower levels of the antimicrobial pepsoriac in their immune system, which disrupts the cellular barrier of the bladder and increases the risk of urinary tract infections.
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Chinese scholars have made progress in the field of low-oxygen rare earth steel research
Time of Update: 2022-10-01
Figure 1 Comparison of inclusions in an imported bearing steel (a) and a double low-oxygen rare earth bearing steel (b). Figure 2 Comparison of tensile fatigue and rolling contact fatigue life of rar
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Chinese scholars have made progress in the analysis of genomic structural variation
Time of Update: 2022-10-01
Due to the high degree of sequence repeatability and the existence of a large number of unknown complex types in the regions with high incidence of genomic structural variation, there are a large number of misdetection and omission detection in the computational methods based on modeling strategies in traditional genomic analysis, and it is difficult to deeply explore the role of structural variation in the evolution of biological traits and disease generation.
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Professor Liu Wen's team discovered the first specific small molecule inhibitor of the oxygenase JMJD6
Time of Update: 2022-10-01
Recently, the State Key Laboratory of Cell Stress Biology, Fujian Provincial Key Laboratory of Drug New Target Research, and Professor Liu Wen of the School of Pharmacy have found that the small molec
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Zhu Rui and Gong Qihuang research group of the School of Physics have made new progress in full-scale grain boundary optimization of perovskite solar cells
Time of Update: 2022-10-01
Cross-sectional SEM picture of perovskite film, control group (E), experimental group (F)In metal halide perovskite materials, serious non-radiative recombination is prone to occur at the interface between grain aggregates at the submicron scale, which in turn affects carrier transport, promotes ion migration, and introduces deep energy level defects, resulting in a decrease in the efficiency and stability of perovskite solar cells.
